Browse our anti-HYAL2 (HYAL2) Antibodies

Full name:: anti-Hyaluronidase-2 Antibodies (HYAL2)

On www.antibodies-online.com are 103 Hyaluronidase-2 (HYAL2) Antibodies from 20 different suppliers available. Additionally we are shipping HYAL2 Kits (16) and HYAL2 Proteins (8) and many more products for this protein. A total of 130 HYAL2 products are currently listed.

Synonyms:: AI256841, AU020858, AW555733, hyal2, hyal2a, hyal2b, luca-2, LUCA2, oHyal2, si:dkey-42i9.14, xhyal2

list all antibodies	Gene Name	GeneID	UniProt
	HYAL2	8692	Q12891
	HYAL2	15587	O35632
	HYAL2	64468
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Most Popular Reactivities for anti-HYAL2 (HYAL2) Antibodies

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anti-Human HYAL2 Antibodies:

anti-Mouse (Murine) HYAL2 Antibodies:

anti-Rat (Rattus) HYAL2 Antibodies:

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Top referenced anti-HYAL2 Antibodies

Human Polyclonal HYAL2 Primary Antibody for ELISA, WB - ABIN1327669 : Monzón, Manzanares, Schmid, Casalino-Matsuda, Forteza: Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells. in American journal of respiratory cell and molecular biology 2008 (PubMed)
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More Antibodies against HYAL2 Interaction Partners

Rabbit Hyaluronidase-2 (HYAL2) interaction partners

Human Hyaluronidase-2 (HYAL2) interaction partners

an important role for HYAL2 in CD44 (show CD44 Antibodies) alternative splicing.
genetic variation in HYAL2 influences platelet aggregation
Knocking down HYAL2 in HUVECs protected against HA degradation in the glycocalyx by inhibiting the expression and activity of HYAL2 and further blocked the dephosphorylation of eNOS (show NOS3 Antibodies)-Ser (show SIGLEC1 Antibodies)-633 and the decrease in NO production in response to LSS (show LSS Antibodies).
HYAL2 mutations identified as a cause of syndromic orofacial clefting and cor triatriatum sinister in amish families.
our data uncover a previously unsuspected mechanism of how hyaluronan and Hyal-2 control platelet generation.
Data show that DNA methylation (show HELLS Antibodies) at CpG island of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil chemotherapy with respect to progression-free survival.
CD44 (show CD44 Antibodies) knock-down in bovine and human chondrocytes results in release of bound HYAL2.
High expression of S100P (show S100P Antibodies) and HYAL2 is significantly associated with advanced disease and shorter survival of triple-negative breast cancer and S100P (show S100P Antibodies) and HYAL2 could be potential prognostic markers of TNBC.
HYAL2 plays a redundant role in the catalysis of megadalton HA to its 20 kDa intermediate during fertilization.
Lower platelet HYAL2 levels and activity are associated with inflammatory bowel disease.

Mouse (Murine) Hyaluronidase-2 (HYAL2) interaction partners

Hyal2(-/-) mice have increased hyaluronan, which may promote endothelial-to-mesenchymal transition and proliferation of mesenchymal cells leading to congenital heart defects and heart failure.
It was concluded that: HYAL1 (show HYAL1 Antibodies) and HYAL2 are both needed for tissue HA catabolism; 2) HYAL2 is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 (show HYAL1 Antibodies) is HA degradation within liver NPCs.
Hyal2-/- mice present craniofacial abnormalities, including submucosal cleft palate and incompletely penetrant cor triatriatum sinister with hearing loss.
our data uncover a previously unsuspected mechanism of how hyaluronan and Hyal-2 control platelet generation.
Removal of Hyal2 activity resulted in increased levels of hyaluronan creating a risk for cor triatriatum sinister.
hyaluronidase 2 deficiency induces chronic thrombotic microangiopathy with hemolytic anemia in mice.
HYAL1 (show HYAL1 Antibodies) is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 is essential for the degradation of extracellular HA in all kidney regions
HYAL2 plays a redundant role in the catalysis of megadalton HA to its 20 kDa intermediate during fertilization.
Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction
Hyal-2 enhancement of tumor necrosis factor-alpha (show TNF Antibodies)-stimulated cytotoxicity in fibroblasts is blocked by Transforming growth factor-beta1.

Cow (Bovine) Hyaluronidase-2 (HYAL2) interaction partners

CD44 (show CD44 Antibodies) knock-down in bovine and human chondrocytes results in release of bound HYAL2.
HYAL2 expression improves the blastocyst rate and embryo quality, an effect which requires CD44 (show CD44 Antibodies) activity and MAPK (show MAPK1 Antibodies) signaling.
May degrade hyaluronan by analogy to human HYAL2, which is a weak acid-active hyaluronidase (show HAase Antibodies). Serves as an entry receptor for jaagsiekte sheep retrovirus in sheep and bovine as well as for enzootic nasal tumor virus in sheep.

HYAL2 Antigen Profile

Antigen Summary

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.

Alternative names and synonyms associated with HYAL2

hyaluronoglucosaminidase 2 S homeolog (hyal2.S) antibody
hyaluronoglucosaminidase 2 (HYAL2) antibody
hyaluronoglucosaminidase 2b (hyal2b) antibody
hyaluronoglucosaminidase 2 (hyal2) antibody
hyaluronoglucosaminidase 2 L homeolog (hyal2.L) antibody
hyaluronoglucosaminidase 2 (Hyal2) antibody

AI256841 antibody
AU020858 antibody
AW555733 antibody
hyal2 antibody
hyal2a antibody
hyal2b antibody
luca-2 antibody
LUCA2 antibody
oHyal2 antibody
si:dkey-42i9.14 antibody
xhyal2 antibody

Protein level used designations for anti-Hyaluronidase-2 (HYAL2) Antibodies

hyaluronidase 2 b , hyaluronoglucosaminidase 2 , hyaluronidase-2 , hyaluronidase 2 , hyaluronidase 2 a , hyaluronidase-2-like , PH-20 homolog , PH20 homolog , hyal-2 , hyaluronoglucosaminidase-2 , lung carcinoma protein 2 , lysosomal hyaluronidase , GPI-anchored surface protein , JSRV envelope protein receptor

GENE ID	SPECIES
380470	Xenopus laevis
415908	Gallus gallus
460391	Pan troglodytes
484760	Canis lupus familiaris
559228	Danio rerio
702484	Macaca mulatta
100009375	Oryctolagus cuniculus
100144942	Xenopus (Silurana) tropicalis
100337508	Xenopus laevis
100407141	Callithrix jacchus
100453650	Pongo abelii
8692	Homo sapiens
15587	Mus musculus
64468	Rattus norvegicus
443154	Ovis aries
281838	Bos taurus

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Show all anti-Hyaluronidase-2 (HYAL2) Antibodies with Pubmed References