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anti-Human HYAL2 Antibodies:
anti-Mouse (Murine) HYAL2 Antibodies:
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Human Polyclonal HYAL2 Primary Antibody for ELISA, WB - ABIN1327669
Monzón, Manzanares, Schmid, Casalino-Matsuda, Forteza: Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells. in American journal of respiratory cell and molecular biology 2008
Show all 3 Pubmed References
an important role for HYAL2 in CD44 (show CD44 Antibodies) alternative splicing.
genetic variation in HYAL2 influences platelet aggregation
Knocking down HYAL2 in HUVECs protected against HA degradation in the glycocalyx by inhibiting the expression and activity of HYAL2 and further blocked the dephosphorylation of eNOS (show NOS3 Antibodies)-Ser (show SIGLEC1 Antibodies)-633 and the decrease in NO production in response to LSS (show LSS Antibodies).
HYAL2 mutations identified as a cause of syndromic orofacial clefting and cor triatriatum sinister in amish families.
our data uncover a previously unsuspected mechanism of how hyaluronan and Hyal-2 control platelet generation.
Data show that DNA methylation (show HELLS Antibodies) at CpG island of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil chemotherapy with respect to progression-free survival.
CD44 (show CD44 Antibodies) knock-down in bovine and human chondrocytes results in release of bound HYAL2.
High expression of S100P (show S100P Antibodies) and HYAL2 is significantly associated with advanced disease and shorter survival of triple-negative breast cancer and S100P (show S100P Antibodies) and HYAL2 could be potential prognostic markers of TNBC.
HYAL2 plays a redundant role in the catalysis of megadalton HA to its 20 kDa intermediate during fertilization.
Lower platelet HYAL2 levels and activity are associated with inflammatory bowel disease.
Hyal2(-/-) mice have increased hyaluronan, which may promote endothelial-to-mesenchymal transition and proliferation of mesenchymal cells leading to congenital heart defects and heart failure.
It was concluded that: HYAL1 (show HYAL1 Antibodies) and HYAL2 are both needed for tissue HA catabolism; 2) HYAL2 is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 (show HYAL1 Antibodies) is HA degradation within liver NPCs.
Hyal2-/- mice present craniofacial abnormalities, including submucosal cleft palate and incompletely penetrant cor triatriatum sinister with hearing loss.
Removal of Hyal2 activity resulted in increased levels of hyaluronan creating a risk for cor triatriatum sinister.
hyaluronidase 2 deficiency induces chronic thrombotic microangiopathy with hemolytic anemia in mice.
HYAL1 (show HYAL1 Antibodies) is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 is essential for the degradation of extracellular HA in all kidney regions
Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction
Hyal-2 enhancement of tumor necrosis factor-alpha (show TNF Antibodies)-stimulated cytotoxicity in fibroblasts is blocked by Transforming growth factor-beta1.
HYAL2 expression improves the blastocyst rate and embryo quality, an effect which requires CD44 (show CD44 Antibodies) activity and MAPK (show MAPK1 Antibodies) signaling.
May degrade hyaluronan by analogy to human HYAL2, which is a weak acid-active hyaluronidase (show HAase Antibodies). Serves as an entry receptor for jaagsiekte sheep retrovirus in sheep and bovine as well as for enzootic nasal tumor virus in sheep.
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
hyaluronidase 2 b
, hyaluronoglucosaminidase 2
, hyaluronidase 2
, hyaluronidase 2 a
, PH-20 homolog
, PH20 homolog
, lung carcinoma protein 2
, lysosomal hyaluronidase
, GPI-anchored surface protein
, JSRV envelope protein receptor