HYAL2 antibody (AA 142-157)

Catalog No. ABIN3031264

Product Details anti-HYAL2 Antibody

Target: HYAL2 (Hyaluronidase-2 (HYAL2))

Binding Specificity: AA 142-157

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HYAL2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids 142-157 (VRNWQDKDVYRRLSRQ-human) were used as the immunogen for this HYAL2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the HYAL2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the HYAL2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for HYAL2

Target: HYAL2 (Hyaluronidase-2 (HYAL2))

Alternative Name: HYAL2 (HYAL2 Products)

Synonyms: hyal2 antibody, hyal2b antibody, luca-2 antibody, luca2 antibody, xhyal2 antibody, si:dkey-42i9.14 antibody, hyal2a antibody, LUCA2 antibody, AI256841 antibody, AU020858 antibody, AW555733 antibody, oHyal2 antibody, hyaluronoglucosaminidase 2 S homeolog antibody, hyaluronoglucosaminidase 2 antibody, hyaluronoglucosaminidase 2b antibody, hyaluronoglucosaminidase 2 L homeolog antibody, hyal2.S antibody, HYAL2 antibody, hyal2b antibody, hyal2 antibody, hyal2.L antibody, Hyal2 antibody

Background: Hyaluronoglucosaminidase 2, also known as hyaluronidase 2, and LuCa-2, is an enzyme that in humans is encoded by the HYAL2 gene. HYAL2 cDNAs encode a preprotein with an N-terminal signal peptide. Northern blot analysis indicated that the gene was expressed in all human tissues tested except adult brain, and Western blot analysis detected the protein in all mouse tissues examined except adult brain. HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored protein on the cell surface and serves as a receptor for entry into the cell of the jaagsiekte sheep retrovirus (JSRV). The findings of Rai et al.(2001) that HYAL2 is a GPI-anchored protein on the cell surface showed that GFP would likely be cleaved from HYAL2 during GPI addition, leaving HYAL2 on the cell surface and resulting in GFP transit to the lysosome for degradation.

UniProt: Q12891

Pathways: Transition Metal Ion Homeostasis, Glycosaminoglycan Metabolic Process