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The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins\; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.
cadherin EGF LAG seven-pass G-type receptor 1
, cadherin family member 9
, cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
, flamingo homolog 2
, protocadherin flamingo 2
, flamingo-like protein celsr1
, seven-pass transmembrane receptor