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anti-3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) Antibodies

The protein encoded by HMGCL belongs to the HMG-CoA lyase family. Additionally we are shipping HMGCL Proteins (11) and HMGCL Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HMGCL 15356 P38060
HMGCL 3155 P35914
HMGCL 79238 P97519
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Top anti-HMGCL Antibodies at antibodies-online.com

Showing 10 out of 105 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-HMGCL Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of HMG-CoA lyase / HMGCL Antibody (Center) in WiDr cell line lysates (35ug/lane). This demonstrates the HMGCL antibody detected the HMGCL protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Hmgcl  Sample Tissue: Rat Thymus lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB HMGCL Antibody (Center)  western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the HMGCL antibody detected the HMGCL protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA, WB HMGCL monoclonal antibody (M01), clone 4F4-D1 Western Blot analysis of HMGCL expression in A-431 Western Blot analysis of HMGCL expression in transfected 293T cell line by HMGCL monoclonal antibody (M01), clone 4F4-D1.Lane 1: HMGCL transfected lysate(34.4 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB HMGCL Antibody (N-term)  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HMGCL antibody detected the HMGCL protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Dog Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details

HMGCL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HMGCL Antibodies

  1. Human Monoclonal HMGCL Primary Antibody for ELISA, WB - ABIN561291 : Puisac, Arnedo, Casale, Ribate, Castiella, Ramos, Ribes, Pérez-Cerdá, Casals, Hegardt, Pié: Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria. in Journal of inherited metabolic disease 2010 (PubMed)
    Show all 2 references for ABIN561291

  2. Human Polyclonal HMGCL Primary Antibody for EIA, WB - ABIN952759 : Fu, Runquist, Montgomery, Miziorko, Kim: Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN952759

  3. Cow (Bovine) Polyclonal HMGCL Primary Antibody for WB - ABIN2776938 : Fu, Runquist, Forouhar, Hussain, Hunt, Miziorko, Kim: Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria. in The Journal of biological chemistry 2006 (PubMed)

More Antibodies against HMGCL Interaction Partners

Human 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) interaction partners

  1. this is the first study describing HMGCL deficiency caused by uniparental disomy.

  2. This efficient UPLC-MS/MS assay permits rapid and high sensitive determination of HMGCR (show HMGCR Antibodies) enzyme activity, tracing potential alterations in cholesterol biosynthesis.

  3. analysis of HMGCLL1 (show HMGCLL1 Antibodies) as an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase and comparison with MHGCL

  4. An alternative transcript of HMGCS2 (show HMGCS2 Antibodies) carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.

  5. levels of enzyme activity do not strongly correlate with formation of inter-subunit adducts by HMGCL mutants. C170S, C266S, and C323S proteins do not form inter-subunit disulfide adducts but such an adduct is restored in the C170S/C174S double mutant.

  6. Crystal structures of ternary complexes of WT HMGCL with the competitive inhibitor 3-hydroxyglutaryl-CoA and of the catalytically deficient HMGCL R41M mutant with substrate HMG-CoA have been determined to 2.4 and 2.2 A.

  7. We report on a new case of 3-hydroxy-3-methylglutaric aciduria particular by its late onset in a 3-year-old patient. Molecular investigation identified two new sequence modifications in the HMGCL gene: c.494G>A (p.Arg165Gln) and c.820G>A (p.Gly274Arg).

  8. A role is suggested for arginine-41 in deprotonation or enolization of acetyldithio-CoA, implicating this residue in the HMG (show SSRP1 Antibodies)-CoA cleavage reaction chemistry that leads to acetyl-CoA (show LPCAT2 Antibodies) product formation.

  9. Data describe the DNA mutational analysis of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.

  10. Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase

HMGCL Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HMGCL

  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (hmgcl) antibody
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (HMGCL) antibody
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AFUA_7G01720) antibody
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (NFIA_114450) antibody
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ACLA_065820) antibody
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AOR_1_910074) antibody
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (PMAA_004600) antibody
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TSTA_103060) antibody
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ARB_04874) antibody
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TRV_06573) antibody
  • 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl) antibody
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (Hmgcl) antibody
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) (hmgcl) antibody
  • Afu7g01720 antibody
  • AO090038000541 antibody
  • AW476067 antibody
  • HL antibody
  • zgc:56248 antibody

Protein level used designations for HMGCL

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase , 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) , 3-hydroxy-3-methylglutarate-CoA lyase , HL , HMG-CoA lyase , hydroxymethylglutaryl-CoA lyase, mitochondrial , 3-hydroxy-3-methylglutaryl-CoA lyase , hydroxymethylglutaricaciduria , mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase , 3-hydroxy-3-methylglutaryl-Coenzyme A lyase

GENE ID SPECIES
432233 Xenopus laevis
456624 Pan troglodytes
710833 Macaca mulatta
3504221 Aspergillus fumigatus Af293
4589480 Neosartorya fischeri NRRL 181
4704707 Aspergillus clavatus NRRL 1
5997540 Aspergillus oryzae RIB40
7030025 Talaromyces marneffei ATCC 18224
8102925 Talaromyces stipitatus ATCC 10500
9522067 Arthroderma benhamiae CBS 112371
9580122 Trichophyton verrucosum HKI 0517
100174514 Pongo abelii
15356 Mus musculus
3155 Homo sapiens
317658 Bos taurus
79238 Rattus norvegicus
396316 Gallus gallus
394190 Danio rerio
478187 Canis lupus familiaris
Selected quality suppliers for anti-HMGCL (HMGCL) Antibodies
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