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The protein encoded by HMGCL belongs to the HMG-CoA lyase family. Additionally we are shipping HMGCL Proteins (11) and HMGCL Kits (1) and many more products for this protein.
Showing 10 out of 94 products:
Human Monoclonal HMGCL Primary Antibody for ELISA, WB - ABIN561291
Puisac, Arnedo, Casale, Ribate, Castiella, Ramos, Ribes, Pérez-Cerdá, Casals, Hegardt, Pié: Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria. in Journal of inherited metabolic disease 2010
Show all 2 references for ABIN561291
Human Polyclonal HMGCL Primary Antibody for EIA, WB - ABIN952759
Fu, Runquist, Montgomery, Miziorko, Kim: Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. in The Journal of biological chemistry 2010
Show all 2 references for ABIN952759
Cow (Bovine) Polyclonal HMGCL Primary Antibody for WB - ABIN2776938
Fu, Runquist, Forouhar, Hussain, Hunt, Miziorko, Kim: Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria. in The Journal of biological chemistry 2006
this is the first study describing HMGCL deficiency caused by uniparental disomy.
This efficient UPLC-MS/MS assay permits rapid and high sensitive determination of HMGCR (show HMGCR Antibodies) enzyme activity, tracing potential alterations in cholesterol biosynthesis.
analysis of HMGCLL1 (show HMGCLL1 Antibodies) as an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase and comparison with MHGCL
An alternative transcript of HMGCS2 (show HMGCS2 Antibodies) carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.
levels of enzyme activity do not strongly correlate with formation of inter-subunit adducts by HMGCL mutants. C170S, C266S, and C323S proteins do not form inter-subunit disulfide adducts but such an adduct is restored in the C170S/C174S double mutant.
Crystal structures of ternary complexes of WT HMGCL with the competitive inhibitor 3-hydroxyglutaryl-CoA and of the catalytically deficient HMGCL R41M mutant with substrate HMG-CoA have been determined to 2.4 and 2.2 A.
We report on a new case of 3-hydroxy-3-methylglutaric aciduria particular by its late onset in a 3-year-old patient. Molecular investigation identified two new sequence modifications in the HMGCL gene: c.494G>A (p.Arg165Gln) and c.820G>A (p.Gly274Arg).
A role is suggested for arginine-41 in deprotonation or enolization of acetyldithio-CoA, implicating this residue in the HMG (show SSRP1 Antibodies)-CoA cleavage reaction chemistry that leads to acetyl-CoA (show LPCAT2 Antibodies) product formation.
Data describe the DNA mutational analysis of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.
Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase
The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
, 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
, 3-hydroxy-3-methylglutarate-CoA lyase
, HMG-CoA lyase
, hydroxymethylglutaryl-CoA lyase, mitochondrial
, 3-hydroxy-3-methylglutaryl-CoA lyase
, mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase
, 3-hydroxy-3-methylglutaryl-Coenzyme A lyase