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The protein encoded by MTHFS is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. Additionally we are shipping MTHFS Antibodies (64) and many more products for this protein.
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Human MTHFS Protein expressed in Escherichia coli (E. coli) - ABIN667396
Lim, Wang, Hartge, Cozen, Kelemen, Chanock, Davis, Blair, Schenk, Rothman, Lan: Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study. in Blood 2007
Show all 2 references for 667396
Expression of the MTHFS cDNA in MCF-7 cells increased the concentration of NADA required to deplete cellular folate.
The intronic Single nucleotide polymorphism in MTHFS had no significant effect on the risk of diabetic nephropathy in Taiwanese patients with T2D.
The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene.
, 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
, 5,10-methenyl-tetrahydrofolate synthetase
, methenyl-THF synthetase
, 5, 10-methenyltetrahydrofolate synthetase