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A Kinase (PRKA) Anchor Protein 5 Proteins (AKAP5)

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. Additionally we are shipping AKAP5 Antibodies (68) and AKAP5 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AKAP5 9495 P24588
AKAP5 238276 D3YVF0
AKAP5 171026  
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Top AKAP5 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,193.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,082.83
Details

AKAP5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for A Kinase (PRKA) Anchor Protein 5 (AKAP5) Interaction Partners

Human A Kinase (PRKA) Anchor Protein 5 (AKAP5) interaction partners

  1. Cigarette smoke-induced changes in AKAP5 and AKAP12 in patients with COPD (show ARCN1 Proteins) may affect efficacy of pharmacotherapy.

  2. human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330

  3. GPR30 interacted with membrane-associated guanylate kinases and protein kinase A-anchoring protein (AKAP) 5 in the plasma membrane in a PDZ-dependent manner.

  4. a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells.

  5. Patients with bipolar disorder have higher density of AKAP5-expressing neurons in the anterior cingulate cortex compared with controls.

  6. AKAP79, PKC (show PRRT2 Proteins), PKA and PDE4 (show PDE4A Proteins) participate in a Gq-linked muscarinic receptor (show CHRM5 Proteins) and adenylate cyclase 2 (show ADCY2 Proteins) cAMP signalling complex.

  7. The results of this study suggested that antagonizing the TRPV1 (show TRPV1 Proteins)-AKAP79 interaction will be a useful strategy for inhibiting inflammatory hyperalgesia.

  8. AKAP5 Pro100Leu effects on emotion processing might be task-dependent with Pro homozygotes showing lower control of emotional interference, but more efficient processing of task-relevant emotional stimuli.

  9. Antagonizing the interaction between AKAP79 and TRPV1 (show TRPV1 Proteins) inhibits inflammatory hyperalgesia.

  10. the direct anchoring of both PKA and AC to TRPV1 (show TRPV1 Proteins) by AKAP79/150 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia.

Cow (Bovine) A Kinase (PRKA) Anchor Protein 5 (AKAP5) interaction partners

  1. the C-helix of protein kinase A inhibitory regulatory subunit is identified as a highly dynamic switch which relays cyclic AMP (show TMPRSS5 Proteins) binding to the helical catalytic-subunit binding regions

Mouse (Murine) A Kinase (PRKA) Anchor Protein 5 (AKAP5) interaction partners

  1. This study demonstrated that the AKAP150 oordinates metabotropic glutamate (show GRIN1 Proteins) receptor sensitization of peripheral sensory neurons.

  2. Thus, our present study revealed that AKAP5 plays a significant role in the regulation of sympathetic nerve activities.

  3. Identify a novel cardioprotective role for AKAP5 that is mediated by regulating the activities of cardiac CaN and CaMKII (show CAMK2G Proteins) and highlight a significant role for cardiac beta-ARs (show SLURP1 Proteins) in this phenomenon.

  4. endothelial-dependent dilation of resistance arteries is enabled by MEP (show CTSL1 Proteins)-localized AKAP150, which ensures the proximity of PKC to TRPV4 (show TRPV4 Proteins) channels and the coupled channel gating necessary for efficient communication from endothelial to smooth muscle cells

  5. Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa (show KCNMA1 Proteins) channel remodeling, which contributes to vasoconstriction during diabetes mellitus.

  6. a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells.

  7. Anchoring of protein kinase A and adenylyl cyclase by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA (show GRIA3 Proteins) receptor activity.

  8. the direct anchoring of both PKA and AC to TRPV1 (show TRPV1 Proteins) by AKAP79/150 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia.

  9. Results show that in the same protein complex in which PKA augments L currents, AKAP79/150 directs calcineurin (show PPP3CA Proteins) to activate NFAT (show NFATC1 Proteins) and initiate a longer-term feedback loop that upregulates M-channel expression, countering increased neuronal excitability.

  10. AKAP150 null mice secrete less insulin (show INS Proteins) yet have better glucose handling due to increased insulin (show INS Proteins) sensitivity in target tissues. Tethering of phosphatases to a seven-residue sequence of Akap5 is the main molecular event for this.

AKAP5 Protein Profile

Protein Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.

Gene names and symbols associated with AKAP5

  • A kinase (PRKA) anchor protein 5 (AKAP5)
  • A kinase (PRKA) anchor protein 5 (Akap5)
  • 3526401B18Rik protein
  • AKAP protein
  • AKAP-5 protein
  • AKAP5 protein
  • AKAP75 protein
  • Akap79 protein
  • AKAP 150 protein
  • AKAP150 protein
  • BB098886 protein
  • Gm258 protein
  • H21 protein
  • P75 protein
  • P150 protein

Protein level used designations for AKAP5

A kinase (PRKA) anchor protein 5 , A-kinase anchor protein 5 , A-kinase anchor protein 5-like , a-kinase anchor protein 5-like , A-kinase anchor protein 79 kDa , A-kinase anchor protein, 79kDa , A-kinase anchoring protein 75/79 , AKAP 79 , AKAP-5 , cAMP-dependent protein kinase regulatory subunit II high affinity binding protein , cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein , A-kinase anchor protein 75 kDa , AKAP 75 , anchor protein regulatory subunit (AKAP75) , A-kinase anchor protein 150 kDa , AKAP 150 , RII-B-binding protein

GENE ID SPECIES
428917 Gallus gallus
467480 Pan troglodytes
707162 Macaca mulatta
100385734 Callithrix jacchus
100461419 Pongo abelii
100599249 Nomascus leucogenys
9495 Homo sapiens
480354 Canis lupus familiaris
281612 Bos taurus
238276 Mus musculus
171026 Rattus norvegicus
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