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anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Antibodies

ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Additionally we are shipping ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Kits (41) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ADAMTS4 361332  
ADAMTS4 240913 Q8BNJ2
ADAMTS4 9507 O75173
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Top anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies at antibodies-online.com

Showing 10 out of 136 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-ADAMTS4 Antibody Titration: 0.2-1 ug/mlPositive Cont... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-ADAMTS4 Antibody (C-term) in mouse cereb... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-ADAMTS4 Antibody (C-term) (ABIN391642) i... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of cartilage using anti-ADAMTS4 antibody ... 50 μg Log in to see 6 to 8 Days
$500.50
Details
Mouse Rabbit Un-conjugated WB ADAMTS4 Polyclonal Antibody 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB Anti-ADAMTS4 antibody, Western blotting Lane 1: Rat Brain Tissue Lysat... 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-ADAMTS4 antibody  ABIN1048291 IHC staining of human cartilage. Im... 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-ADAMTS4 antibody  ABIN1048290 IHC staining of human cartilage. Im... 50 μg Log in to see 8 to 10 Days
$451.00
Details

ADAMTS4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus) , , , ,

Mouse (Murine) , , , ,

Human , , , ,
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Top referenced anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies

  1. Human Polyclonal ADAMTS4 Primary Antibody for WB - ABIN391642 : Tortorella, Pratta, Liu, Abbaszade, Ross, Burn, Arner: The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN391642

  2. Human Polyclonal ADAMTS4 Primary Antibody for EIA, WB - ABIN359602 : Tortorella, Burn, Pratta, Abbaszade, Hollis, Liu, Rosenfeld, Copeland, Decicco, Wynn, Rockwell, Yang, Duke, Solomon, George, Bruckner, Nagase, Itoh, Ellis, Ross, Wiswall, Murphy, Hillman, Hollis et al.: Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. ... in Science (New York, N.Y.) 1999 (PubMed)
    Show all 2 references for ABIN359602

  3. Cow (Bovine) Polyclonal ADAMTS4 Primary Antibody for IHC, WB - ABIN2776877 : Lee, Hwang, Park, Lee, Park, Kang, Lee, Kim, Park, Park: Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. in Journal of clinical pathology 2011 (PubMed)
    Show all 2 references for ABIN2776877

  4. Human Polyclonal ADAMTS4 Primary Antibody for IHC (p) - ABIN122612 : Yurube, Takada, Suzuki, Kakutani, Maeno, Doita, Kurosaka, Nishida: Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. in Arthritis research & therapy 2012 (PubMed)

More Antibodies against ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Interaction Partners

Rabbit ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. a single injection of ADAMTS5 (show ADAMTS5 Antibodies) siRNA induced the suppression of degradation in rabbit nucleus pulposus tissues

Horse (Equine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. Studies suggest that miR (show MYLIP Antibodies)-140 is an important regulator of cartilage development and homeostasis in cord blood-derived mesenchymal stromal cells (eCB-MSCs) that may act, in part, through the regulation of CXCL12 (show CXCL12 Antibodies) and ADAMTS-5 (show ADAMTS5 Antibodies).

  2. ADAMTS5 (show ADAMTS5 Antibodies) is present in degenerative suspensory ligament desmitis as a high molecular weight complex

Cow (Bovine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. ADAMTS4 participates in the regulation of muscle development in cattle.

  2. aggrecanase activity (a) is responsible for early TNFalpha (show TNF Antibodies)-dependent aggrecan (show ACAN Antibodies) cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.

  3. ADAMTS4 and ADAMTS5 (show ADAMTS5 Antibodies) are inhibited by alpha2-macroglobulin (show A2M Antibodies)

  4. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Antibodies)

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. Results show that ADAMTS15 (show ADAMTS15 Antibodies) and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development

  2. aggrecan (show ACAN Antibodies) and brevican (show BCAN Antibodies) proteolysis is compensated in Adamts4-/- or Adamts5 (show ADAMTS5 Antibodies)-/- mice by ADAMTS (show ADAMTS1 Antibodies) proteoglycanase (show MMP3 Antibodies) family members but a threshold of versican (show Vcan Antibodies) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 Antibodies) proteoglycanase (show MMP3 Antibodies) during spinal cord injury

  3. The serine protease (show F2 Antibodies) tissue plasminogen activator (tPA (show PLAT Antibodies)) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Antibodies), were identified as Reelin (show RELN Antibodies) cleaving enzymes.

  4. ADAMTS-4 cleaves Reelin (show RELN Antibodies) in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 (show LSP1 Antibodies) cleaves the N-t site only, while p75 (show NGFR Antibodies) cleaves both sites.

  5. Data demonstrate that Adamts1 (show ADAMTS1 Antibodies) and Adamts4 play redundant and essential roles in perinatal kidney development.

  6. Drastic down-regulation of Adamts4 observed at both E16 (show SLC7A5 Antibodies) and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.

  7. proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue

  8. ADAMTS1 (show ADAMTS1 Antibodies), ADAMTS4, and ADAMTS5 (show ADAMTS5 Antibodies) are expressed in patterns that relate to the expression pattern of versican (show Vcan Antibodies) in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary.

  9. ADAMTS-5 (show ADAMTS5 Antibodies) is entirely responsible for cleavage in the interglobular domain, but cleavage in the chondroitin sulfate-rich region may be driven by ADAMTS-4

  10. comparison of aggrecan (show ACAN Antibodies) loss with aggrecan (show ACAN Antibodies) processing in mice with single and double deletions of ADAMTS-4 and -5 activity (Deltacat)

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. These data demonstrate that the antibody is specific to ADAMTS4 and ADAMTS5 (show ADAMTS5 Antibodies) and inhibits their aggrecanase activity at molecular and cellular levels.

  2. ADAMTS4 is largely associated with synapses, and is the main brevican (show BCAN Antibodies)-processing protease.

  3. ADAMTS-4 is a potential biomarker and an early diagnostic indicator of knee osteoarthritis.

  4. A positive feedback loop involving sSema4D/IL-6 (show IL6 Antibodies) and TNFalpha (show TNF Antibodies)/ADAMTS-4 may contribute to the pathogenesis of rheumatoid arthritis.

  5. CCN1 (show CCNA2 Antibodies) suppresses ADAMTS-4 activity and that CCN1 (show CCNA2 Antibodies) overexpression is directly correlated with chondrocyte cloning in osteoarthritis cartilage. The TGFbeta (show TGFB1 Antibodies)/CCN1 (show CCNA2 Antibodies) axis plays a role in chondrocyte cluster formation through inhibition of ADAMTS-4.

  6. Our results indicate that miR (show MLXIP Antibodies)-125b plays an important role in regulating the expression of ADAMTS-4 in human chondrocytes

  7. We conclude that the upregulation of TNF-alpha (show TNF Antibodies) and ADAMTS-5 (show ADAMTS5 Antibodies), but not ADAMTS-4, may play an important role in degenerative cartilage endplate-induced low back pain.

  8. The restricted expression of ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Antibodies) and their increased expression in gestational trophoblastic diseases suggest that these 2 ADAMTS (show ADAMTS13 Antibodies) subtypes are associated with human placentation and the development of gestational trophoblastic diseases.

  9. This study highlights that the affinity between a ligand and LRP1 (show LRP1 Antibodies) dictates the rate of internalization and suggests that LRP1 (show LRP1 Antibodies) is a major traffic controller of the two aggrecanases, especially under inflammatory conditions, where the protein levels of ADAMTS-4 increase, but those of ADAMTS-5 (show ADAMTS5 Antibodies) do not.

  10. This is the first evidence of crosstalk between TNF-alpha (show TNF Antibodies) and ADAMTS-4 in relation to osteoarthritis cartilage degradation.

ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Antigen Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Gene names and symbols associated with ADAMTS4

  • ADAM metallopeptidase with thrombospondin type 1 motif, 4 (ADAMTS4) antibody
  • aggrecanase-1 (ADAMTS-4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 19 (Adamts19) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 19 (ADAMTS19) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) (ADAMTS5) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5) antibody
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4) antibody
  • ADAMTS-like 4 (ADAMTSL4) antibody
  • 3830423K05 antibody
  • ADAM-TS4 antibody
  • ADAMTS-2 antibody
  • ADAMTS-4 antibody
  • ADAMTS-11 antibody
  • ADAMTS4 antibody
  • ADAMTS5 antibody
  • ADAMTS13 antibody
  • ADMP-1 antibody
  • DKFZp469J0817 antibody
  • mKIAA0688 antibody

Protein level used designations for ADAMTS4

ADAM metallopeptidase with thrombospondin type 1 motif, 4 , aggrecanase-1 , A disintegrin and metalloproteinase with thrombospondin motifs 4-like , A disintegrin and metalloproteinase with thrombospondin motifs 19 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19 , ADAM metallopeptidase with thrombospondin type 1 motif, 19 , ADAM metallopeptidase with thrombospondin type 1 motif, 13 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 , ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM metallopeptidase with thrombospondin type 1 motif, 5 , ADAM metallopeptidase with thrombospondin type 1 motif, 19-like , aggrecanase-2 , A disintegrin and metalloproteinase with thrombospondin motifs 4 , ADAM-TS 4 , ADAMTS-4 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 , ADAM-TS4 , Aggrecanase , a disintegrin and metallopeptidase with thrombospondin motifs 4 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 , ADMP-1 , disintegrin and metalloproteinase with thrombospondin motifs 2

GENE ID SPECIES
457453 Pan troglodytes
719927 Macaca mulatta
100008765 Oryctolagus cuniculus
100033914 Equus caballus
100171426 Pongo abelii
100409334 Callithrix jacchus
100482466 Ailuropoda melanoleuca
100606067 Nomascus leucogenys
361332 Rattus norvegicus
415600 Gallus gallus
417152 Gallus gallus
427971 Gallus gallus
462039 Pan troglodytes
473153 Pan troglodytes
473935 Pan troglodytes
487713 Canis lupus familiaris
537961 Bos taurus
705362 Macaca mulatta
707672 Macaca mulatta
100008799 Oryctolagus cuniculus
100066005 Equus caballus
240913 Mus musculus
9507 Homo sapiens
66015 Rattus norvegicus
286806 Bos taurus
488651 Canis lupus familiaris
100712995 Cavia porcellus
101106565 Ovis aries
100514576 Sus scrofa
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