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ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS5 Antibodies (121) and ADAMTS5 Proteins (9) and many more products for this protein.
Showing 10 out of 38 products:
Human ADAMTS5 ELISA Kit for Sandwich ELISA - ABIN649163
Mern, Fontana, Beierfuß, Thomé, Hegewald et al.: A combinatorial relative mass value evaluation of endogenous bioactive proteins in three-dimensional cultured nucleus pulposus cells of herniated intervertebral discs: identification of potential ... in PLoS ONE 2013
Show all 6 Pubmed References
research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality
TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (show ACAN ELISA Kits) and Vcan (show Vcan ELISA Kits) by an ADAMTS (show ADAMTS1 ELISA Kits) other than TS5.
Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (show ADAMTS4 ELISA Kits) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.
aggrecan (show ACAN ELISA Kits) and brevican (show BCAN ELISA Kits) proteolysis is compensated in Adamts4 (show ADAMTS4 ELISA Kits)-/- or Adamts5-/- mice by ADAMTS (show ADAMTS1 ELISA Kits) proteoglycanase (show MMP3 ELISA Kits) family members but a threshold of versican (show Vcan ELISA Kits) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 ELISA Kits) proteoglycanase (show MMP3 ELISA Kits) during spinal cord injury
The present study reveals ADAMT-5 expression by mast cells(MCs (show SMCP ELISA Kits)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.
Western blot analyses indicated that aggrecanase (show ADAMTS4 ELISA Kits)-generated proteoglycan (show Vcan ELISA Kits) fragments are produced after SCI.
RelA/p65 (show NFkBP65 ELISA Kits) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.
Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.
this study identified, for the first time, several genes that have an ADAMTS-5-independent role in osteoarthritis(OA), identifying them as possible OA initiation candidates.
The serine protease (show F2 ELISA Kits) tissue plasminogen activator (tPA (show PLAT ELISA Kits)) and two matrix metalloproteinases, ADAMTS-4 (show ADAMTS4 ELISA Kits) and ADAMTS-5, were identified as Reelin (show RELN ELISA Kits) cleaving enzymes.
Results provide direct evidence indicating that Fibulin-2 (show FBLN2 ELISA Kits) is a novel substrate of ADAMTS-5 and that this proteolysis could alter the cellular microenvironment affecting the balance between protumor and antitumor effects associated to both Fibulin-2 (show FBLN2 ELISA Kits) and the ADAMTSs metalloproteases.
Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5, MMP13 (show MMP13 ELISA Kits), and decreased COL2A1 (show COL2A1 ELISA Kits) expression.
Single Nucleotide Variants of Candidate Genes in Aggrecan (show ACAN ELISA Kits) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes
RREB1 (show RREB1 ELISA Kits) cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM (show MMRN1 ELISA Kits)) of the intervertebral disc.
Matrilin 2 (show MATN2 ELISA Kits) accumulation associated with relative ADAMTS5 deficiency may contribute to the mechanism underlying calcific aortic valve disease progression.
In osteoarthritis (OA) chondrocytes, hydrostatic pressure (HP) restores the expression levels of some miRNAs, downregulates MMP-13 (show MMP13 ELISA Kits), ADAMTS-5, and HDAC-4 (show HDAC4 ELISA Kits), and modulates the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway activation.
we investigated whether important polymorphisms in the ADAMTS4 (show ADAMTS4 ELISA Kits) and ADAMTS5 genes affect osteoarthritis (OA) susceptibility. ADAMTS4 (show ADAMTS4 ELISA Kits) and ADAMTS5 genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (show ADAMTS4 ELISA Kits) (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.
Increased ADAMTS5 levels were observed in placental insufficiency cases.
ADAMTS5 protein levels in semen were significantly lower in males with infertility. Sperm count and motility showed a negative correlation with levels of ADAMTS5 protein expression.
Overexpression of ADAMTS5 is associated with migration and invasion of non-small cell lung cancer.
The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (show ADAMTS4 ELISA Kits)) explains the minor contribution of the MMP enzymes to aggrecan (show ACAN ELISA Kits) catabolism in vivo.
ADAMTS4 (show ADAMTS4 ELISA Kits) and ADAMTS5 are inhibited by alpha2-macroglobulin (show A2M ELISA Kits)
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (show ADAMTS4 ELISA Kits) and ADAMTS-5
Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.
ADAM metallopeptidase with thrombospondin type 1 motif, 5
, a disintegrin and metalloproteinase with thrombospondin motifs 5-like
, A disintegrin and metalloproteinase with thrombospondin motifs 5
, ADAM-TS 5
, a disintegrin and metalloproteinase with thrombospondin motifs 11
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)