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The protein encoded by ARFRP1 is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. Additionally we are shipping ARFRP1 Kits (16) and ARFRP1 Proteins (6) and many more products for this protein.
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One or more of 7 genes residing in a chromosome 20q13.3 CNV region appears to influence BMI. The strongest candidate is ARFRP1.
Propose that Arfrp1 exposes a binding site on AP-1 (show FOSB Antibodies) that recognizes the Vangl2 (show VANGL2 Antibodies) sorting motif for capture into a transport vesicle destined for the proximal surface of a polarized epithelial cell.
The GTPase (show RACGAP1 Antibodies) ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.
Data show that ADP-ribosylation factor-related protein 1 (ARFRP1) is associated mainly with the trans-Golgi compartment and the trans-Golgi network (TGN (show TG Antibodies)) and is an essential regulatory factor for targeting of golgin-97 (show GOLGA1 Antibodies) and golgin-245 (show GOLGA4 Antibodies) onto Golgi membranes.
These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245 (show GOLGA4 Antibodies), to the Golgi.
Results show that ARL1 and ARFRP1 regulate retrograde transport of Shiga toxin to the TGN (show TG Antibodies) and anterograde transport of VSVG from the TGN (show TG Antibodies), respectively.
ARFRP1 and the Golgi apparatus play an important role in lipoprotein maturation in the liver.
data indicate that ARFRP1 in the liver is involved in the regulation of IGF1 (show IGF1 Antibodies) secretion and GLUT2 (show SLC2A2 Antibodies) sorting and is thereby essential for normal growth and glycogen (show GYS1 Antibodies) storage
Arfrp1 appears to be involved in sorting of GLUT4 (show SLC2A4 Antibodies).
Lipid droplets of adipocytes of Arfrp1(-/-) mice were smaller and exhibited ultrastructural alterations, such as a disturbed interaction of small lipid particles with larger droplets.
ADP-ribosylation factor (show ARF1 Antibodies)-like GTPase (show RACGAP1 Antibodies) ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin (show CDH1 Antibodies).
This study provides the first detailed analysis of the regional distribution of ARFRP1 in the mouse brain and a quantitative view of its changes following sleep deprivation.
The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified.
ADP-ribosylation factor related protein 1
, ADP-ribosylation factor-related protein 1
, putative ADP-ribosylation factor related protein 1 variant 1
, ARF-related protein 1
, SCG10 like-protein
, helicase-like protein NHL