ATP Citrate Lyase Proteins (ACLY)

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Additionally we are shipping ACLY Antibodies (124) and ACLY Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACLY 47 P53396
ACLY 104112 Q91V92
Rat ACLY ACLY 24159 P16638
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Top ACLY Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process SOD1 dissolution curves 1 mg Log in to see 70 Days
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 20 to 21 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days

ACLY Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for ATP Citrate Lyase (ACLY) Interaction Partners

Human ATP Citrate Lyase (ACLY) interaction partners

  1. CUL3 (show CUL3 Proteins) interacts with ACLY through its adaptor protein, KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade ACLY in cells

  2. we found that depletion of ATP citrate lyase suppressed tumor growth, which suggests that ATP citrate lyase-related inhibitors might be potential therapeutic approaches for breast cancer.

  3. Results show that ACLY is a key phosphoprotein effector of IL-2 (show IL2 Proteins)-mediated T-cell responses. ACLY becomes phosphorylated on serine 455 in T lymphocytes upon IL-2 (show IL2 Proteins)-driven activation of AKT (show AKT1 Proteins), and depletion or inactivation of ACLY compromises IL-2 (show IL2 Proteins)-promoted T-cell growth.

  4. ACLY was also required for LMW-E-mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo In clinical specimens of breast cancer, the absence of LMW-E and low expression of adipophilin (PLIN2 (show PLIN2 Proteins)), a marker of lipid droplet formation, associated with favorable prognosis

  5. ACC1 and ACLY regulate the levels of ETV4 (show ETV4 Proteins) under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1/ACLY-alpha-ketoglutarate-ETV4 (show ETV4 Proteins) axis is a novel means by which metabolic states regulate transcriptional output

  6. ACL activity is associated with increased ATP. Activation of this IGF1 (show IGF1 Proteins)/ACL/cardiolipin pathway combines anabolic signaling with induction of mechanisms needed to provide required ATP.

  7. These results suggest that the combined expression of GLUT1 (show SLC2A1 Proteins) and ACLY could be a more valuable prognostic factor than their individual expression in node-negative patients with NSCLC.

  8. Polymorphisms of ATP citrate lyase gene is associated with recurrence in colorectal cancer.

  9. SNP rs9912300 in ACLY gene was significantly associated with response to therapy in hepatocellular carcinoma

  10. The activation of AMPK (show PRKAA1 Proteins) under ACLY knockdown conditions may lead to p53 (show TP53 Proteins) activation, ultimately leading to cellular senescence.

Mouse (Murine) ATP Citrate Lyase (ACLY) interaction partners

  1. ACL (show APOC4 Proteins) plays a critical role in epigenetic regulation of diabetic renal fibrosis.

  2. ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr (show LDLR Proteins) knockout mouse model of metabolic dysregulation.

  3. IL-4 (show IL4 Proteins) signaling co-opts the Akt (show AKT1 Proteins)-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA (show LPCAT1 Proteins) synthesis, leading to increased histone acetylation and macrophage gene induction.

  4. These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS (show TLR4 Proteins) signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation

  5. Results suggest a role for DNA methyltransferase 1 (DNMT1 (show DNMT1 Proteins)) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR (show MLXIP Proteins)-148a-dependent mechanism for regulating DNMT1 (show DNMT1 Proteins) during adipogenesis.

  6. Differences between human and rodent pancreatic islets: low pyruvate carboxylase (show PC Proteins), atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

  7. Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL (show APOC4 Proteins) in lipid metabolism.

  8. Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival.

  9. crucial role of hepatic ATP-citrate lyase in lipid and glucose metabolism

  10. findings suggest that ATP-citrate lyase activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene expression

Pig (Porcine) ATP Citrate Lyase (ACLY) interaction partners

  1. The results of this study indicate that a C/T mutation affects ACL mRNA expression, probably via the activator protein 2 (show TFAP2A Proteins).

Cow (Bovine) ATP Citrate Lyase (ACLY) interaction partners

  1. we identified three non-synonymous mutations in ACLY exons in five beef cattle populations. Single nucleotide polymorphism (SNP) g.17127C>T is significantly associated with chest girth and body height, and with body slanting length. SNP g.40427T>C is significantly associated with an increase in chest girth. ACLY gene are associated with growth traits in beef cattle in northwest China

ACLY Protein Profile

Protein Summary

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with ATP Citrate Lyase Proteins (ACLY)

  • ATP citrate lyase (ACLY)
  • ATP citrate lyase (acly)
  • ATP citrate lyase (ATPCL)
  • ATP-citrate synthase (AaeL_AAEL004297)
  • citrate synthase, mitochondrial (CpipJ_CPIJ010291)
  • ATP-citrate synthase (Bm1_26245)
  • atp-citrate synthase (ACL)
  • ATP citrate lyase (Acly)
  • ATP citrate lyase a (aclya)
  • A730098H14Rik protein
  • ACL protein
  • acly protein
  • anon-WO0140519.179 protein
  • ATPCL protein
  • AW538652 protein
  • BcDNA:LD21334 protein
  • cb722 protein
  • CG8322 protein
  • Clatp protein
  • dATPCL protein
  • DDBDRAFT_0205389 protein
  • DDBDRAFT_0235360 protein
  • DDB_0205389 protein
  • DDB_0235360 protein
  • DmATPCL protein
  • Dmel\\CG8322 protein
  • l(2)01466 protein
  • l(2)k09217 protein
  • n(2)k09217 protein
  • zgc:92008 protein

Protein level used designations for ATP Citrate Lyase Proteins (ACLY)

ATP citrate lyase , ATP citrate synthase , ATP-citrate synthase-like , ATP-citrate lyase , ATPCL-PD , ATPCL-PE , ATPCL-PF , CG8322-PD , CG8322-PE , CG8322-PF , ATP-citrate synthase , citrate synthase, mitochondrial , atp-citrate synthase , ATP-citrate (pro-S-)-lyase , citrate cleavage enzyme

100053195 Equus caballus
454672 Pan troglodytes
495086 Xenopus laevis
587157 Strongylocentrotus purpuratus
708501 Macaca mulatta
8621508 Dictyostelium discoideum AX4
100405725 Callithrix jacchus
100422779 Felis catus
100439535 Pongo abelii
100467494 Ailuropoda melanoleuca
36760 Drosophila melanogaster
5564509 Aedes aegypti
6042632 Culex quinquefasciatus
6100149 Brugia malayi
7201075 Phaeodactylum tricornutum CCAP 1055/1
47 Homo sapiens
104112 Mus musculus
24159 Rattus norvegicus
100125957 Sus scrofa
511135 Bos taurus
395373 Gallus gallus
607852 Canis lupus familiaris
654404 Ovis aries
436922 Danio rerio
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