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ATP7B is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. Additionally we are shipping ATP7B Proteins (10) and ATP7B Kits (7) and many more products for this protein.
Showing 10 out of 154 products:
Human Polyclonal ATP7B Primary Antibody for ICC, IF - ABIN151824
Safaei, Otani, Larson, Rasmussen, Howell: Transport of cisplatin by the copper efflux transporter ATP7B. in Molecular pharmacology 2008
Show all 8 references for ABIN151824
Human Monoclonal ATP7B Primary Antibody for ELISA, WB - ABIN393414
Singleton, McInnes, Cater, Winnall, McKirdy, Yu, Taylor, Ke, Richardson, Mercer, La Fontaine: Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B. in The Journal of biological chemistry 2010
Show all 5 references for ABIN393414
Human Polyclonal ATP7B Primary Antibody for ICC, IF - ABIN151825
Guo, Nyasae, Braiterman, Hubbard: NH2-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells. in American journal of physiology. Gastrointestinal and liver physiology 2005
Show all 2 references for ABIN151825
Human Polyclonal ATP7B Primary Antibody for IF, IHC - ABIN1533712
Dunham, Matthews, Burton, Ashurst, Howe, Ashcroft, Beare, Burford, Hunt, Griffiths-Jones, Jones, Keenan, Oliver, Scott, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey et al.: The DNA sequence and analysis of human chromosome 13. ... in Nature 2004
Human Monoclonal ATP7B Primary Antibody for ELISA, WB - ABIN560009
Ansede, Wright, St Claire, Hart, Gefroh, Brouwer: Characterization of sandwich-cultured hepatocytes as an in vitro model to assess the hepatobiliary disposition of copper. in Drug metabolism and disposition: the biological fate of chemicals 2009
Human Polyclonal ATP7B Primary Antibody for EIA, WB - ABIN452773
Martinez-Balibrea, Martínez-Cardús, Musul��n, Ginés, Manzano, Aranda, Plasencia, Neamati, Abad: Increased levels of copper efflux transporter ATP7B are associated with poor outcome in colorectal cancer patients receiving oxaliplatin-based chemotherapy. in International journal of cancer. Journal international du cancer 2009
Data show that CD4 (show CD4 Antibodies)(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 (show IL17A Antibodies) termed Th17 and gammadelta17 cells.
The endocytosis and signaling of the gamma-delta T cell coreceptor WC1 are regulated by a dileucine motif.
WC1 is a hybrid gamma-delta TCR coreceptor and pattern recognition receptor for pathogenic bacteria.
Identification of differences in the signal transduction through the endodomains of WC1 contributes to understanding the functional role of the WC1 coreceptors in the gammadelta T cell responses.
Specific receptors in the WC1 family directly participate in Leptospira recognition and/or activation of gamma-delta T cells.
These findings revealed that despite the existence of a distinct bovine CD4 (show CD4 Antibodies)(+)CD25 (show IL2RA Antibodies)(high) T cell population, which showed Foxp3 (show FOXP3 Antibodies) transcription/expression, natural regulatory activity did not reside in this cell population
Sudies demonstrate that WC1 molecules are encoded by a large, multi-gene family whose transcripts undergo extensive alternative splicing.
With the capability of generating relatively higher throughput in a short time period, the NGS assay is a viable alternative to Sanger sequencing for detecting ATP7B mutations causally linked to Wilson disease in the clinical diagnostic laboratory
analysis of the geographic distribution of ATP7B mutations in Wilson disease [review]
Extrinsic expressing WT ATP7B reduced CuCl2-induced copper accumulation and enhanced cellular copper tolerance by accelerating copper excretion, which was selectively compromised by R778L and P992L mutations.
Metal-dependent movement of the first four metal-binding domains in ATP7B may be a trigger that initiates the overall catalytic cycle.
Nine out of the thirty-two pediatric Turkish WD patients had no mutations in the ATP7B gene.
Novel mutation of the ATP7B gene was found in Chinese families with pre-symptomatic Wilson's disease.
Wilson disease causing p.T788I, p.V1036I and p.R1038G-fsX83 mutations lead to functional deficiency in ATP7B protein.
The present results demonstrate the design and evaluation of a low-density microarray for the detection of 62 mutations in ATP7B gene, and show that a microarray based approach can be cost-effective for detecting a large number of mutations simultaneously
Screening for the two exons 14 and 18 of the ATP7B gene is important in Egyptian patients especially in suspected patients without hepatic manifestations.
The ATP7B gene testing for the boy, his sister, and their parents detected two novel missense mutations in the boy and his sister, i.e., compound heterozygous mutations in exon 7 and exon 13
Data indicate that the copper-transporting ATPase (show DNAH8 Antibodies) gene (Atp7b) knockout mice showed a drastic, time-dependent accumulation of hepatic copper.
The aim of this study was to identify copper disturbances according to various brain compartments and further dissect the causal relationship between copper storage and neuronal damage using Atp7b(-/-) mice.
DKWSLLL sequence is essential for ATP7b sorting at the TGN (show TG Antibodies), transport from the TGN (show TG Antibodies) to the PM, endocytosis, and recycling to the TGN (show TG Antibodies) and PM.
Ligand-activated nuclear receptors FXR/NR1H4 (show NR1H4 Antibodies) and GR/NR3C1 (show NR3C1 Antibodies) and nuclear receptor interacting partners are less abundant in Atp7b(-/-) hepatocyte nuclei.
By performing dynamic PET, authors obtained the first real-time measurements of 64Cu distribution in the organs or tissues of Atp7b -/- mice.
Clusterin (show CLU Antibodies) and COMMD1 (show COMMD1 Antibodies) independently regulate degradation of the mammalian copper ATPases ATP7A (show ATP7A Antibodies) and ATP7B.
Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease.
The Jackson toxic milk mouse as a model for copper loading
Both Atp7a (show ATP7A Antibodies) and Atp7b are expressed in glomeruli; however, Atp7b is also seen in the kidney medulla suggesting that glomeruli are responsible for regulating copper levels in the filtrate
Mice homozygous for the recessive txJ mutation examined at 6 months of age exhibited a reduced number of amyloid plaques and diminished plasma Abeta (show APP Antibodies) levels. Homozygosity for txJ increased survival and lowered endogenous CNS Abeta (show APP Antibodies).
A copper-dependent ATPase (show DNAH8 Antibodies) hydrolysis in a native Golgi-enriched preparation from liver, was characterized.
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
ATPase, Cu++ transporting, beta polypeptide
, copper-transporting ATPase beta subunit
, ATPase, Cu++ transporting, beta polypeptide (Wilson disease)
, Wilson's disease protein
, copper-transporting ATPase
, copper-transporting ATPase 2
, copper-transporting ATPase 2-like
, ATPase, Cu(2+)- transporting, beta polypeptide
, Wilson disease-associated protein
, copper pump 2
, Wilson protein
, toxic milk
, wilson disease-associated protein homolog
, ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease)
, PINA gene, promoter
, pineal night-specific ATPase
, ATPase, Cu(2+)-transporting, beta polypeptide
, ATPase 7B protein
, scavenger receptor cysteine-rich type 1 protein M160
, scavenger-receptor protein