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ATPase, H+ Transporting, Lysosomal V0 Subunit A2 Proteins (ATP6V0A2)

The protein encoded by ATP6V0A2 is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. Additionally we are shipping ATP6V0A2 Antibodies (15) and ATP6V0A2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATP6V0A2 23545 Q9Y487
Mouse ATP6V0A2 ATP6V0A2 21871 P15920
Rat ATP6V0A2 ATP6V0A2 116455  
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Top ATP6V0A2 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ATP6V0A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) Interaction Partners

Human ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) interaction partners

  1. Senescence-associated impaired expression of ATP6V0A2 triggers changes in Golgi structure and glycosylation in old fibroblasts, which demonstrates a role of ATP6V0A2 in cellular senescence program.

  2. the results from this study demonstrate that the a2-subunit isoform of Vacuolar ATPase regulates Notch (show NOTCH1 Proteins) signaling in breast tumor cells

  3. Case Report: novel ATP6V0A2 mutations in an infant with cutis laxa.

  4. Expression of a2 vacuolar ATPase in spermatozoa is associated with semen quality and chemokine (show CCL1 Proteins)-cytokine profiles in infertile men.

  5. Mutations in the ATP6V0A2 gene is associated with autosomal recessive cutis laxa.

  6. Data show that the V-ATPase a2-subunit might actually be embedded into and/or closely associated with membrane phospholipids even in the absence of any obvious predicted transmembrane segments.

  7. Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO (show CYTH2 Proteins).

  8. Studies indicate that mutations in the ATP6V0A2 gene were found in families with autosomal recessive cutis laxa.

  9. RTF (Regeneration and tolerance factor), the alpha-2 isoform of the alpha subunit (show POLG Proteins) of vacuolar ATPase, has a role in controlling IL-1 beta (show IL1B Proteins) secretion by regulating P2X7 (show P2RX7 Proteins) activity.

  10. cells were not susceptible to apoptosis when the 70-kDa RTF was present but were when the 50-kDa RTF was present; the increase in levels of the 50-kDa RTF on cells from HIV-positive individuals is important in preventing apoptosis

Mouse (Murine) ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) interaction partners

  1. Report Atp6v0a2 up-regulation/inflammatory response during preimplantation period of pregnancy may lead to successful pregnancy outcome.

  2. Deceased expression of Atp6v0a2 in the various immune cell populations of the spleen and blood suggests that the maternal environment is not supportive to fetus and leads to poor pregnancy outcome in the abortion-prone mating model

  3. a2V regulates the delicate cytokine and chemokine (show CCL1 Proteins) networks that coordinate the recruitment of macrophages for successful placental development and growth at the feto-maternal interface.

  4. Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO (show CYTH2 Proteins).

  5. These results suggest that ISF/ShIF confers stromal cells with enhanced supporting activities for HSCs by modulating Wnt (show WNT2 Proteins)-activity and the extracellular matrix.

  6. Data demonstrate the crucial role of early endosomal acidification and V-ATPase (show ATP6V1H Proteins)/ARNO (show CYTH2 Proteins)/Arf6 (show ARF6 Proteins) interactions in the regulation of the endocytic degradative pathway.

ATP6V0A2 Protein Profile

Protein Summary

The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.

Gene names and symbols associated with ATP6V0A2

  • ATPase, H+ transporting, lysosomal V0 subunit a2 (ATP6V0A2)
  • ATPase, H+ transporting, lysosomal V0 subunit A2 (Atp6v0a2)
  • ATPase, H+ transporting, lysosomal V0 subunit a2a (atp6v0a2a)
  • 8430408C20Rik protein
  • A2 protein
  • AI385560 protein
  • ARCL protein
  • ARCL2A protein
  • ATP6a2 protein
  • Atp6n1d protein
  • Atp6n2 protein
  • atp6v0a2 protein
  • AW489264 protein
  • C76904 protein
  • Cc1-3 protein
  • ISF protein
  • J6b7 protein
  • RTF protein
  • SHIF protein
  • si:ch211-199i18.4 protein
  • Stv1 protein
  • Tj6 protein
  • TJ6M protein
  • TJ6s protein
  • V-ATPase 116 kDa protein
  • V-ATPase a2 protein
  • VPH1 protein
  • WSS protein

Protein level used designations for ATP6V0A2

ATPase, H+ transporting, lysosomal V0 subunit a , V-type proton ATPase 116 kDa subunit a , V-type proton ATPase 116 kDa subunit a isoform 2 , vacuolar H(+)-transporting ATPase 116 kDa subunit, a2 isoform , A2V-ATPase , lysosomal H(+)-transporting ATPase V0 subunit a2 , regeneration and tolerance factor , v-ATPase 116 kDa , v-type proton ATPase 116 kDa subunit a , vacuolar proton translocating ATPase 116 kDa subunit a , V-ATPase 116 kDa , vacuolar proton translocating ATPase 116-kDa subunit a2 , ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD) , T-cell expressing clone j6 , immune suppressor factor J6B7 , ATPase, H+ transporting, lysosomal V0 subunit a2

GENE ID SPECIES
395473 Gallus gallus
23545 Homo sapiens
486245 Canis lupus familiaris
338038 Bos taurus
21871 Mus musculus
116455 Rattus norvegicus
561469 Danio rerio
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