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The protein encoded by ACO2 belongs to the aconitase/IPM isomerase family. Additionally we are shipping ACO2 Antibodies (108) and ACO2 Kits (23) and many more products for this protein.
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Human ACO2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003654
Lauble, Kennedy, Beinert, Stout: Crystal structures of aconitase with isocitrate and nitroisocitrate bound. in Biochemistry 1992
The identification of ACO1 (show ACO1 Proteins), ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.
Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection
Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy.
immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men
Ogg1 (show OGG1 Proteins) chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.
Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells
Gastric cancer patients with lower ACO2 expression have a shorter survival time than those with higher ACO2 expression.
Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2.
these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter.
Lon (show LONP1 Proteins) protease selectively recognizes and degrades the oxidized, hydrophobic form of aconitase (show ACO1 Proteins) after mild oxidative modification, but that severe oxidation results in aconitase (show ACO1 Proteins) aggregation, which makes it a poor substrate for Lon (show LONP1 Proteins).
ACO2 is often deleted in colorectal cancer (show DCC Proteins) but is unlikely to be the true target of the deletions
Activation of mitochondrial aconitase is acetylation-dependent.
IRP-1 (show ACO1 Proteins),-2 are indispensable for regulation of mammalian iron homeostasis at the post-implantation stage of murine embryonic development
aconitase activity can be regulated by at least two mechanisms: oxidation/reduction and phosphorylation/dephosphorylation
study examined the sites and mechanisms of aconitase inactivation by peroxynitrite (ONOO-), a strong oxidant and nitrating agent readily formed from superoxide anion and nitric oxide generated by mitochondria
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.
aconitate hydratase, mitochondrial
, mitochondrial aconitate hydratase
, aconitase 2, mitochondrial
, aconitate hydratase, mitochondrial-like
, citrate hydro-lyase
, mitochondrial aconitase (nuclear aco2 gene)
, heart aconitase