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anti-Actinin, alpha 2 (ACTN2) Antibodies

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Additionally we are shipping ACTN2 Kits (31) and ACTN2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACTN2 11472 Q9JI91
ACTN2 291245  
ACTN2 88 P35609
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Top anti-ACTN2 Antibodies at antibodies-online.com

Showing 10 out of 82 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-ACTN2  Antibody Titration: 1.25 µg/mL  Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$229.00
Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB ACTN2 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35µg/lane).This demonstrates the ACTN2 antibody detected the ACTN2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IHC (fro), IHC (p)   0.5 mL Log in to see 6 to 8 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Mouse Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Cow Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescence analysis of methanol-fixed HeLa, using alpha Actinin 2 antibody at 1:200 dilution. Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 6 to 8 Days
$500.50
Details
Mouse Rabbit Un-conjugated WB ACTN2 Antibody (C-term)  western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the ACTN2 antibody detected the ACTN2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details

ACTN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Rat (Rattus)
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Top referenced anti-ACTN2 Antibodies

  1. Human Polyclonal ACTN2 Primary Antibody for EIA, WB - ABIN950370 : Chiu, Bagnall, Ingles, Yeates, Kennerson, Donald, Jormakka, Lind, Semsarian: Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysis. in Journal of the American College of Cardiology 2010 (PubMed)
    Show all 5 references for ABIN950370

  2. Cow (Bovine) Polyclonal ACTN2 Primary Antibody for IHC, WB - ABIN2776829 : Bos, Theis, Tajik, Gersh, Ommen, Ackerman: Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. in American heart journal 2008 (PubMed)
    Show all 2 references for ABIN2776829

  3. Human Monoclonal ACTN2 Primary Antibody for IHC (fro), IHC (p) - ABIN114743 : Goncharova, Kam, Geiger: The involvement of adherens junction components in myofibrillogenesis in cultured cardiac myocytes. in Development (Cambridge, England) 1992 (PubMed)
    Show all 2 references for ABIN114743

  4. Chicken Polyclonal ACTN2 Primary Antibody for WB - ABIN2780085 : Hirschy, Schatzmann, Ehler, Perriard: Establishment of cardiac cytoarchitecture in the developing mouse heart. in Developmental biology 2006 (PubMed)

  5. Chicken Polyclonal ACTN2 Primary Antibody for IHC, WB - ABIN2776830 : Eldstrom, Choi, Steele, Fedida: SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism. in FEBS letters 2003 (PubMed)

More Antibodies against ACTN2 Interaction Partners

Mouse (Murine) Actinin, alpha 2 (ACTN2) interaction partners

  1. Data suggest that kindlin-2 (Kind2/Fermt2 (show FERMT2 Antibodies)) interacts with actin alpha 2 (Actn2) and integrin beta 1 (Itgb1 (show ITGB1 Antibodies)) and co-localizes to cardiac sarcomere at Z-disc; knockdown of Kind2 (show FERMT2 Antibodies) leads to dissociation of Actn2 and Itgb1 (show ITGB1 Antibodies).

  2. Data show that alpha-Actinin 2 and CaMKIIalph (show NEXN Antibodies)a exist in complex with GluN2B in fo (show CAMK2 Antibodies)rebrain.

  3. Data demonstrated that the Z-disk proteins, ZASP (show LDB3 Antibodies), titin (show TTN Antibodies) and vinculin (show VCL Antibodies) preferentially bind to alpha-actinin-2. Thus, the loss of alpha-actinin-3 (show ACTN3 Antibodies) changes the overall protein composition of fast fiber Z-disks and alters their elastic properties.

  4. alpha-Actinin (show ACTN1 Antibodies), rapsyn (show RAPSN Antibodies), and surface AChR form a ternary complex.

  5. BPAG1 (show DST Antibodies)-b was detectable in vitro and in vivo as a high molecular mass protein in striated (show NSDHL Antibodies) and heart muscle cells, co-localizing with alpha-actinin-2 and partially with the cytolinker plectin (show PLEC Antibodies) as well as with the intermediate filament protein desmin (show DES Antibodies).

  6. demonstrate that proper membrane localization of a small-conductance Ca(2 (show CA2 Antibodies)+)-activated K(+) channel (show KCNC4 Antibodies) (SK2 (show PAPSS2 Antibodies) or K(Ca)2.2) is dependent on its interacting protein, alpha-actinin2, a major F-actin crosslinking protein (show MACF1 Antibodies).

Human Actinin, alpha 2 (ACTN2) interaction partners

  1. study strengthens the hypothesis that ACTN2 influences caries risk.

  2. The novel heterozygous missense sequence variant ACTN2 cosegregated with a complex cardiomyopathic trait, characterized by the interplay of midapical, nonobstructive HCM, early onset of AF and AV block, as well as regional LV noncompaction.

  3. Clinical evaluation of an Australian family revealed diverse cardiac pathologies in four affected members and genetic testing of the exome identified a pathogenic ACTN2 heterozygous variant (Ala119Thr) that co-segregated with disease.

  4. Study reports a complete high-resolution structure of the 200 kDa alpha-actinin-2 dimer from striated (show NSDHL Antibodies) muscle and explore its functional implications on the biochemical and cellular level.

  5. This study generated the genomic sequences of K88-positive and F18 (show MAMLD1 Antibodies)-positive porcine enteroteoxigenic E. coli (ETEC) strains and examined the phylogenetic distribution of clinical porcine ETEC strains and their plasmid-associated genetic content.

  6. Findigs show that the F-actin-binding protein (show SHROOM3 Antibodies) alpha-actinin-2 targets CaMKIIalpha (show CAMK2 Antibodies) to F-actin in cells by binding to the CaMKII (show CAMK2G Antibodies) regulatory domain.

  7. data provide functional evidence that the primary sequences of alpha-actinin-2 and alpha-actinin-3 (show ACTN3 Antibodies) evolved differences to optimize their functions

  8. This is the first genome-wide linkage analysis that shows mutations in ACTN2 cause HCM

  9. BPAG1 (show DST Antibodies)-b was detectable in vitro and in vivo as a high molecular mass protein in striated (show NSDHL Antibodies) and heart muscle cells, co-localizing with alpha-actinin-2 and partially with the cytolinker plectin (show PLEC Antibodies) as well as with the intermediate filament protein desmin (show DES Antibodies).

  10. Spectrin-like repeats from dystrophin (show DMD Antibodies) and alpha-actinin-2 are not functionally interchangeable.

Zebrafish Actinin, alpha 2 (ACTN2) interaction partners

ACTN2 Antigen Profile

Protein Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.

Gene names and symbols associated with ACTN2

  • actinin, alpha 2 (actn2) antibody
  • actinin, alpha 2 (ACTN2) antibody
  • actinin alpha 2 (Actn2) antibody
  • actinin, alpha 2 (Actn2) antibody
  • 1110008F24Rik antibody
  • ACTN2 antibody
  • CMD1AA antibody
  • MGC89234 antibody
  • wu:fd44c03 antibody
  • zgc:123223 antibody

Protein level used designations for ACTN2

actinin, alpha 2 , alpha 2 actinin , alpha-actinin-2-like , F-actin cross-linking protein , alpha-actinin skeletal muscle , alpha-actinin-2

GENE ID SPECIES
448602 Xenopus (Silurana) tropicalis
469156 Pan troglodytes
100033870 Equus caballus
100481134 Ailuropoda melanoleuca
11472 Mus musculus
291245 Rattus norvegicus
88 Homo sapiens
396263 Gallus gallus
479191 Canis lupus familiaris
100157406 Sus scrofa
536607 Bos taurus
641575 Danio rerio
432169 Xenopus laevis
100350274 Oryctolagus cuniculus
100712846 Cavia porcellus
101116372 Ovis aries
Selected quality suppliers for anti-ACTN2 (ACTN2) Antibodies
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