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Activin Receptor Type IC Proteins (ACVR1C)

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Additionally we are shipping Activin Receptor Type IC Antibodies (90) and Activin Receptor Type IC Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACVR1C 130399 Q8NER5
ACVR1C 269275 Q8K348
ACVR1C 245921 P70539
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Top Activin Receptor Type IC Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Human Cells Human ECD,Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,137.67
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ACVR1C Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Activin Receptor Type IC (ACVR1C) Interaction Partners

Human Activin Receptor Type IC (ACVR1C) interaction partners

  1. Loss of ALK7 expression are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma.

  2. Alk7 is expressed in male germ cells and Sertoli cells.

  3. ACVR (show ACRV1 Proteins) 1C is a tumor suppressor, and lowered ACVR (show ACRV1 Proteins) 1C expression is an important marker for the metastasis, invasion, and prognosis of gallbladder cancer.

  4. Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with metabolic syndrome risk in females and may be involved in cardiovascular remodeling in metabolic syndrome patients.

  5. reduction or lack of ALK7 expression may account for the loss of its ligand sensitivity of breast cancer cells, thereby leading to breast tumor progression.

  6. These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia.

  7. ALK7 and its isoforms are expressed in human placentae of different stages of pregnancy and that their expression is developmentally regulated

  8. ALK7 induces apoptosis through activation of the traditional TGF-beta (show TGFB1 Proteins) pathway components

  9. the Nodal-ALK7 pathway inhibits cell proliferation by inducing G(1) cell cycle arrest

  10. AB and activin B and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6.

Mouse (Murine) Activin Receptor Type IC (ACVR1C) interaction partners

  1. ALK7 protects against pathological cardiac hypertrophy in mice.

  2. These findings suggest that endogenous expression of ALK7 is necessary to maintain repolarizing K+ currents in ventricular cardiomyocytes, and finally prevent action potential prolongation and ventricular arrhythmia.

  3. ALK7 signaling contributes to diet-induced catecholamine resistance in adipose tissue; ALK7 inhibitors may have therapeutic value in human obesity.

  4. Signaling through the TGF beta (show TGFB1 Proteins)-activin receptors ALK4 (show ACVR1B Proteins)/5/7 regulates testis formation and male germ cell development.

  5. Alk7 is involved in modulation of adipose tissue metabolism in response to beta3-adrenergic receptor (show ADRB3 Proteins) activation.

  6. Data indicate that activin receptor ALK7-knockout females showed delayed onset of puberty and abnormal estrous cyclicity.

  7. Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor gamma (show PPARG Proteins) and C/EBPalpha (show CEBPA Proteins).

  8. Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4 (show ACVR1B Proteins)/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity

  9. ALK7 is the signaling receptor for activin AB and activin B and is responsible for activin-mediated secretion of insulin (show INS Proteins) from pancreatic beta cell line, MIN6.

  10. ALK7 is not an essential mediator of Nodal signaling during mesendoderm formation and left-right patterning in the mouse but may instead mediate other activities of Nodal and related ligands in the development or function of particular tissues and organs

Activin Receptor Type IC (ACVR1C) Protein Profile

Protein Summary

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001

Gene names and symbols associated with ACVR1C

  • activin A receptor, type IC (ACVR1C)
  • activin A receptor, type IC (Acvr1c)
  • ACVRLK7 protein
  • Alk-7 protein
  • Alk7 protein
  • C230097P10 protein
  • habrec1 protein

Protein level used designations for ACVR1C

ACTR-IC , ALK-7 , activin receptor type IC , activin receptor type-1C , activin receptor-like kinase 7 , TGF-beta type 1 receptor , activin A receptor, type IC

GENE ID SPECIES
130399 Homo sapiens
269275 Mus musculus
245921 Rattus norvegicus
488361 Canis lupus familiaris
100156756 Sus scrofa
536380 Bos taurus
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