Acyl-CoA Synthetase Long-Chain Family Member 4 Proteins (ACSL4)

The protein encoded by ACSL4 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Additionally we are shipping ACSL4 Antibodies (88) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACSL4 2182 O60488
ACSL4 50790 Q9QUJ7
ACSL4 113976 O35547
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Top ACSL4 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$6,052.17
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,947.17
Details

ACSL4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
,
Rat (Rattus)

Top referenced ACSL4 Proteins

  1. Human ACSL4 Protein expressed in Wheat germ - ABIN1305715 : Zhang, Li, Zhang, Xiao: A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation. in The Journal of biological chemistry 2011 (PubMed)

More Proteins for Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) Interaction Partners

Human Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) interaction partners

  1. Data show that ELOVL7, SOCS3 (show SOCS3 Proteins), ACSL4 and CLU (show CLU Proteins) were upregulated while PRKAR1A (show PRKAR1A Proteins) and ABCG1 (show ABCG1 Proteins) were downregulated in the phlegm-dampness group.

  2. ACSL4 is not only a sensitive monitor of ferroptosis, but also an important contributor of ferroptosis.

  3. ACLS4 and ACLS3 have roles in insulin (show INS Proteins) secretion

  4. Silencing of ACSL4 eliminated the 17beta-estradiol-induced increase in AA and EPA uptake.

  5. ACSL4 plays a tumor-suppressive role in gastric cancer.

  6. Suggest role for ACSL4 expression in development of castration-resistant prostate cancer.

  7. we demonstrate that ACSL4 can be considered a novel activator of the mTOR (show FRAP1 Proteins) pathway

  8. In vitro analysis showed that a recombinant COX-2 enzyme more effectively metabolized 5(S)-HETE to 5-11-diHETE compared to COX-1 enzyme.

  9. Upregulation of ACSL4 is responsible for the increase in triacylglycerol species containing long polyunsaturated fatty acids during activation of hepatic stellate cells.

  10. Report PPARdelta (show PPARD Proteins)-mediated regulatory mechanism for ACSL4 expression in liver tissue and cultured hepatic cells.

Mouse (Murine) Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) interaction partners

  1. ACSL4 plays a tumor-suppressive role in gastric cancer.

  2. Report PPARdelta (show PPARD Proteins)-mediated regulatory mechanism for ACSL4 expression in liver tissue and cultured hepatic cells.

  3. Sequence analysis of a 1.5-kb fragment of the Acsl4 promoter revealed the absence of a TATA box and the presence of many putative binding sites for transcription factors including Sp1 (show SP1 Proteins) and CREB (show CREB1 Proteins).

  4. Acsl4 is a phosphoprotein whose phosphorylation is hormone-dependent.

  5. These results indicate that the ACS4 protein specifically expressed in brain plays an important role in arachidonate metabolism and neuronal differentiation in the brain.

  6. the involvement of SHP2 (show PTPN11 Proteins) activity in the regulation of the expression of the fatty acid-metabolizing enzyme ACSL4

Pig (Porcine) Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) interaction partners

  1. Results indicate that fatty acid binding protein H-FABP (show FABP3 Proteins) and CoA ligase 4 ACSL4 genes might serve as markers to improve fat (IMF (show MDFI Proteins)) content in the breeding system.

  2. ACSL4 Single Nucleotide Polymorphism G2645A is associated with several meat quality traits.

  3. Polymorphisms within the ACSL4 gene are associated with growth and meat quality.

Arabidopsis thaliana Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) interaction partners

  1. The analyses of mutant lines revealed strongly overlapping functions of LACS4 and LACS9 in lipid trafficking from the endoplasmic reticulum to the plastid.

  2. The combined inactivation of LACS1 (show Acsl1 Proteins) and LACS4 in Arabidopsis resulted in conditional pollen sterility and impaired wax biosynthesis.

ACSL4 Protein Profile

Protein Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.

Gene names and symbols associated with ACSL4

  • acyl-CoA synthetase long-chain family member 4a (acsl4a)
  • acyl-CoA synthetase long-chain family member 4 (ACSL4)
  • AcsL4 (acsL4)
  • acyl-CoA synthetase long-chain family member 4 (acsl4)
  • Long-chain-fatty-acid--CoA ligase 4 (acsl4)
  • acyl-CoA synthetase long-chain family member 4 (Acsl4)
  • long chain acyl-CoA synthetase 4 (LACS4)
  • 9430020A05Rik protein
  • acs4 protein
  • acsl3 protein
  • ACSL4 protein
  • AU018108 protein
  • facl4 protein
  • lacs4 protein
  • long-chain acyl-CoA synthetase 4 protein
  • mrx63 protein
  • mrx68 protein
  • T32A16.20 protein
  • T32A16_20 protein
  • zgc:66186 protein

Protein level used designations for ACSL4

acyl-CoA synthetase long-chain family member 4 , long-chain-fatty-acid--CoA ligase 4 , AcsL4 , Long-chain-fatty-acid--CoA ligase 4 , long-chain-fatty-acid--CoA ligase 4-like , LACS 4 , acyl-CoA synthetase 4 , fatty-acid-Coenzyme A ligase, long-chain 4 , lignoceroyl-CoA synthase , long-chain acyl-CoA synthetase 4 , long-chain fatty-acid-Coenzyme A ligase 4 , fatty acid-Coenzyme A ligase, long chain 4 , mACS4 , fatty acid Coenzyme A ligase, long chain 4 , fatty acid-Coenzyme A ligase long chain 4 , acyl-CoA synthetase long-chain family member 3

GENE ID SPECIES
393622 Danio rerio
422345 Gallus gallus
704908 Macaca mulatta
740279 Pan troglodytes
7502699 Desulfobacterium autotrophicum HRM2
100013435 Monodelphis domestica
100036652 Xenopus (Silurana) tropicalis
100073630 Ornithorhynchus anatinus
100342485 Oryctolagus cuniculus
100380405 Salmo salar
100462347 Pongo abelii
100469615 Ailuropoda melanoleuca
100539925 Meleagris gallopavo
2182 Homo sapiens
536628 Bos taurus
50790 Mus musculus
113976 Rattus norvegicus
481018 Canis lupus familiaris
448980 Sus scrofa
100174803 Xenopus laevis
828484 Arabidopsis thaliana
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