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Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembra. Additionally we are shipping Adaptor-Related Protein Complex 1, sigma 2 Subunit Proteins (6) and many more products for this protein.
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sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin (show SORT1 Antibodies) in adipose tissue.
The AP1S2 c.426+1 G>T mutation segregates with the disease in the Pettigrew syndrome family.
A mutation in the 3d intron causes skipping of exon 3 yielding a protein with 3 new AAs (show FGD1 Antibodies) terminating at codon 64. A new nonsense mutation p.Gln66X was found in exon 3. Without AP1S2, defective membrane protein trafficking alters brain neural cell fate.
absence of an AP-1 (show FOSB Antibodies) defect in peripheral tissues is due to functional redundancy among AP-1 (show FOSB Antibodies) subunits
Synaptic vesicle reformation in cultured neurons from adaptor protein complex AP-1 sigma-1B-deficient mice is reduced upon stimulation, and large endosomal intermediates accumulate.
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene.
AP-1 complex subunit sigma-2
, adaptor-related protein complex 1, sigma 2 subunit
, adapter-related protein complex 1 sigma-1B subunit
, adaptor protein complex AP-1 sigma-1B subunit
, clathrin adaptor complex AP1 sigma 1B subunit
, clathrin assembly protein complex 1 sigma-1B small chain
, golgi adaptor HA1/AP1 adaptin sigma-1B subunit
, sigma 1B subunit of AP-1 clathrin
, sigma-adaptin 1B
, adaptor-related protein complex 1 sigma 2 subunit
, adaptor-related protein complex 1, sigma 1 subunit