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Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. Additionally we are shipping Adrenomedullin Kits (101) and Adrenomedullin Proteins (14) and many more products for this protein.
Showing 10 out of 179 products:
Human Polyclonal Adrenomedullin Primary Antibody for FACS, WB - ABIN651196
Kim, Kim, Lee, Park: Adrenomedullin protects against hypoxia/reoxygenation-induced cell death by suppression of reactive oxygen species via thiol redox systems. in FEBS letters 2009
Rat (Rattus) Polyclonal Adrenomedullin Primary Antibody for IHC (fro), IF - ABIN115759
Mulder, Ahrén, Karlsson, Sundler: Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion. in Regulatory peptides 1996
Human Polyclonal Adrenomedullin Primary Antibody for IHC, ELISA - ABIN1583931
Li, Yuan, Chen, Guo, Kang, Wang, Li, Wang, Wang, Yuan, Liu: Effect of simulated microgravity and its associated mechanism on pulmonary circulation in rats. in Biomedical and environmental sciences : BES 2013
Among adrenomedullin, CRP (show CRP Antibodies), and PCT (show UROD Antibodies), procalcitonin demonstrates the highest correlation with the severity of infection.
Results suggest that ADM plays an important role in intrahepatic cholangiocellular carcinoma metastasis, and that ADM signaling of epithelial-mesenchymal transition may represent a valuable therapeutic target in cancer patients.
targeting of the ADM/ADM acceptors/ERK1/2 (show MAPK1/3 Antibodies)/Bcl-2 (show BCL2 Antibodies) pathway may provide a potential strategy through which to induce the apoptosis of osteosarcoma cells.
In addition to its role in the complement system, complement factor H (show CFH Antibodies) has an another role, as a binding protein for the regulatory peptide adrenomedullin. (Review)
AM expression gets rapidly activated by hypoxia through a HIF-1alpha (show HIF1A Antibodies) mediated mechanism, thus characterizing AM as a major survival factor for tumour cells
Allelic variation in ADM and increased plasma MR-proADM are associated with susceptibility to progression of diabetic kidney disease in type 2 diabetic patients.
Adrenomedullin potentiates osteolytic responses in bone to metastatic breast cancer cells.
Plasma adrenomedullin level is enhanced in nasopharyngeal carcinoma.Adrenomedullin is correlated with stage progression and with long-term survival of nasopharyngeal carcinoma patients.
There was a significant increase in plasma AM, VCAM-1 (show VCAM1 Antibodies), and ICAM-1 (show ICAM1 Antibodies), while a significant decrease in plasma basic-Fibroblast growth factor (show FGF2 Antibodies) (b (show ATP5S Antibodies)-FGF) in diabetic patients with peripheral vascular disease (p < 0.05).
the ADM gene has a role in the modulation of peripheral vascular tone
vascular dysfunction was potentially augmented by a decrease in production of the pulmonary vasodilator adrenomedullin
It was concluded that ADM may regulate chloride and fluid secretion from the seminal vesicle, which may affect the composition of the seminal plasma bathing the sperm and, hence, fertility.
Estrogen-induced microRNAs are important for balancing cardiac Adm expression in female mice.
These results indicate the AM-RAMP2 (show RAMP2 Antibodies) system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth.
Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.
The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase (show NOX1 Antibodies) probably by suppressing the local renin (show REN Antibodies)-angiotensin system.
Hypoxia upregulates expression of the Notch ligand Dll4 (show DLL4 Antibodies) and increases Notch (show NOTCH1 Antibodies) signaling in a process requiring the vasoactive hormone adrenomedullin.
Adrenomedullin-RAMP2 (show RAMP2 Antibodies) system is crucially involved in retinal angiogenesis.
ADM signaling is involved in laser-induced CNV formation, because both an ADM antagonist and ADM mAb significantly inhibited it.
Endogenous adrenomedullin is a key factor in secondary lymphedema pathogenesis and provides experimental in vivo evidence of an underlying germ-line genetic predisposition to developing this disorder.
Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR (show CALCRL Antibodies), RAMP2 (show RAMP2 Antibodies) and RAMP3 (show RAMP3 Antibodies) were detected in cotyledonary villous and caruncular epithelial cells.
The present study thus showed that neither leptin (show LEP Antibodies) nor resistin (show RETN Antibodies) affects the expression of endothelin-1 (show EDN1 Antibodies) or adrenomedullin in bovine brain microvascular endothelial cells.
Data suggest that ADM (adrenomedullin) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (show CALCRL Antibodies) (calcitonin gene-related peptide (show CALCA Antibodies) receptor; not adrenomedullin receptor (show GPR182 Antibodies)).
adrenomedullin prevented loss of cerebral autoregulation after fluid percussion injury in a sex-dependent and ERK MAPK (show MAPK1 Antibodies)-dependent manner
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.