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Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. Additionally we are shipping Adrenomedullin Antibodies (240) and Adrenomedullin Kits (92) and many more products for this protein.
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Human Adrenomedullin Protein expressed in Human Cells - ABIN2004468
Hao, Yu, Qi, Luo, Wang: The antifibrosis effect of adrenomedullin in human lung fibroblasts. in Experimental lung research 2011
Evidence show that ADM could affect the growth and differentiation of leukemia cells by modulating RAMPs/CRLR (show CALCRL Proteins) expression, PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) cascade and the ERK/MAPK (show MAPK1 Proteins) signaling pathway.
A panel of three biomarkers (MR-proANP, PCT (show UROD Proteins), and MR-proADM) in patients presenting to the emergency unit with acute dyspnea provides information about the probability of acute heart failure, nonsurvival, and pneumonia.
conclusion supplementation with selenium and coenzyme Q10 (show EIF2C2 Proteins) during four years resulted in less concentration of both copeptin (show AVP Proteins) and MR-proADM
High Adrenomedullin expression is associated with Malignant Pleural Mesothelioma.
Among adrenomedullin, CRP (show CRP Proteins), and PCT (show UROD Proteins), procalcitonin demonstrates the highest correlation with the severity of infection.
Results suggest that ADM plays an important role in intrahepatic cholangiocellular carcinoma metastasis, and that ADM signaling of epithelial-mesenchymal transition may represent a valuable therapeutic target in cancer patients.
targeting of the ADM/ADM acceptors/ERK1/2/Bcl-2 (show BCL2 Proteins) pathway may provide a potential strategy through which to induce the apoptosis of osteosarcoma cells.
In addition to its role in the complement system, complement factor H (show CFH Proteins) has an another role, as a binding protein for the regulatory peptide adrenomedullin. (Review)
AM expression gets rapidly activated by hypoxia through a HIF-1alpha (show HIF1A Proteins) mediated mechanism, thus characterizing AM as a major survival factor for tumour cells
Allelic variation in ADM and increased plasma MR-proADM are associated with susceptibility to progression of diabetic kidney disease in type 2 diabetic patients.
vascular dysfunction was potentially augmented by a decrease in production of the pulmonary vasodilator adrenomedullin
It was concluded that ADM may regulate chloride and fluid secretion from the seminal vesicle, which may affect the composition of the seminal plasma bathing the sperm and, hence, fertility.
Estrogen-induced microRNAs are important for balancing cardiac Adm expression in female mice.
These results indicate the AM-RAMP2 (show RAMP2 Proteins) system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth.
Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.
The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase (show NOX1 Proteins) probably by suppressing the local renin (show REN Proteins)-angiotensin system.
Hypoxia upregulates expression of the Notch ligand Dll4 (show DLL4 Proteins) and increases Notch (show NOTCH1 Proteins) signaling in a process requiring the vasoactive hormone adrenomedullin.
Adrenomedullin-RAMP2 (show RAMP2 Proteins) system is crucially involved in retinal angiogenesis.
ADM signaling is involved in laser-induced CNV formation, because both an ADM antagonist and ADM mAb significantly inhibited it.
Endogenous adrenomedullin is a key factor in secondary lymphedema pathogenesis and provides experimental in vivo evidence of an underlying germ-line genetic predisposition to developing this disorder.
Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR (show CALCRL Proteins), RAMP2 (show RAMP2 Proteins) and RAMP3 (show RAMP3 Proteins) were detected in cotyledonary villous and caruncular epithelial cells.
The present study thus showed that neither leptin (show LEP Proteins) nor resistin (show RETN Proteins) affects the expression of endothelin-1 (show EDN1 Proteins) or adrenomedullin in bovine brain microvascular endothelial cells.
Data suggest that ADM (adrenomedullin) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (show CALCRL Proteins) (calcitonin gene-related peptide (show CALCA Proteins) receptor; not adrenomedullin receptor (show GPR182 Proteins)).
adrenomedullin prevented loss of cerebral autoregulation after fluid percussion injury in a sex-dependent and ERK MAPK (show MAPK1 Proteins)-dependent manner
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.