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The protein encoded by ADH1B is a member of the alcohol dehydrogenase family. Additionally we are shipping Alcohol Dehydrogenase 1B (Class I), beta Polypeptide Proteins (10) and Alcohol Dehydrogenase 1B (Class I), beta Polypeptide Kits (1) and many more products for this protein.
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Besides the amount and frequency of alcohol drinking, the combination of ALDH2 (show ALDH2 Antibodies) and ADH1B polymorphisms predicts smoking initiation. This study suggests that alcohol tolerance regulated by ALDH2 (show ALDH2 Antibodies) and ADH1B polymorphisms is associated with smoking initiation, and facilitates the development of targeted interventions to reduce smoking prevalence.
This study showed ADH1B appears to affect phenotypic traits via both alcohol-mediated and alcohol-independent effects.
ADH1B gene Arg47His variant was associated with the decreased esophageal cancer risk.
Polymorphisms on ADH1B and ALDH2 (show ALDH2 Antibodies) had significant indirect effects on hepatocellular carcinoma risk, mediated through alcohol drinking
nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes encoding enzymes of alcohol and reactive aldehyde metabolism, respectively, are prevalent among East Asians.
Data suggest that activation of the AhR (show AHR Antibodies)/ARNT (show ARNT Antibodies) (aryl hydrocarbon receptor/aryl hydrocarbon receptor (show AHR Antibodies) nuclear translocator (show ARNT Antibodies)) signaling by AhR (show AHR Antibodies) ligands (environmental carcinogens TCDD/3MC/PCB (show PC Antibodies) used here) represents novel mechanism for regulating the expression of ADH1B (alcohol dehydrogenase 1B) and other isoenzymes (ADH4 (show ADH4 Antibodies), ADH6 (show ADH6 Antibodies)) in hepatocytes.
No significant relationship was measured between ADH1B Arg47His and gastric cancer risk; ALDH2 (show ALDH2 Antibodies) Glu487Lys and CYP4502E1 polymorphisms could be risk factors for the development of gastric cancer in the Chinese population.
ADH1B rs1229984 and ALDH2 (show ALDH2 Antibodies) rs671 polymorphisms increased the risk of Alzheimer's disease in all the genetic models.
ADH1B Arg47His polymorphism, but not the ALDH2 (show ALDH2 Antibodies) Glu487Lys variation, may influence development of colorectal cancer in the Chinese population.
No significant association was found between the ADH2 Arg47His polymorphism and risk of Parkinson's disease in the co-dominant, dominant, or recessive models.
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.
alcohol dehydrogenase 2
, alcohol dehydrogenase
, ADH, beta subunit
, alcohol dehydrogenase 1B
, alcohol dehydrogenase 2 (class I), beta polypeptide
, alcohol dehydrogenase subunit beta
, aldehyde reductase
, alcohol dehydrogenase (class I), beta polypeptide
, alcohol dehydrogenase 2 (subunit B)
, alcohol dehydrogenase IB (class I), beta polypeptide