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anti-Aldehyde Dehydrogenase 5 Family, Member A1 (ALDH5A1) Antibodies

This protein belongs to the aldehyde dehydrogenase family of proteins. Additionally we are shipping ALDH5A1 Proteins (11) and ALDH5A1 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ALDH5A1 7915 P51649
ALDH5A1 291133  
ALDH5A1 214579 Q8BWF0
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Top anti-ALDH5A1 Antibodies at antibodies-online.com

Showing 10 out of 129 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of Aldh5A1 in mouse liver lysate with AP30045PU-N Aldh5A1 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$283.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-ALDH5A1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Placenta WB Suggested Anti-ALDH5A1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of ALDH5A1 Antibody (C-term) (ABIN388270) in SK-BR-3 cell line lysates (35 µg/lane). ALDH5A1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with *ALDH5A1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Goat Un-conjugated EIA, WB AP22386PU-N ALDH5A1 antibody staining of Human Liver lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Cow Goat Un-conjugated EIA, IHC (p), WB AP22390PU-N ALDH5A1 antibody staining of paraffin embedded Human Liver at 5 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. AP22390PU-N ALDH5A1 antibody staining of Human Liver lysate at 0.5 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated FACS, IHC, WB 100 μL Log in to see 2 to 3 Days
$283.50
Details

ALDH5A1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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, , , , ,
Rat (Rattus) ,
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Mouse (Murine) ,
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Top referenced anti-ALDH5A1 Antibodies

  1. Human Polyclonal ALDH5A1 Primary Antibody for EIA, WB - ABIN356986 : Knerr, Pearl, Bottiglieri, Snead, Jakobs, Gibson et al.: Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (gamma-hydroxybutyric aciduria). Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- ... in Journal of inherited metabolic disease 2007 (PubMed)
    Show all 3 references for ABIN356986

  2. Human Polyclonal ALDH5A1 Primary Antibody for EIA, WB - ABIN499267 : Vasiliou, Pappa: Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. in Pharmacology 2000 (PubMed)

More Antibodies against ALDH5A1 Interaction Partners

Human Aldehyde Dehydrogenase 5 Family, Member A1 (ALDH5A1) interaction partners

  1. Pearl (show AP3B1 Antibodies) et al. identify 3 new pathogenic mutations in the ALDH5A1 gene previously unreported in the literature. EXON: 1 Nucleotide change: c.412 C>T Change in protein: p.L138F EXON: 4 Nucleotide change: c.754G>T Change in protein: p.Q252X EXON: 8 Nucleotide change: c.1360G>A Change in protein: p.A454T

  2. Missense mutation in ALDH5A1 is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability.

  3. Results show that opioid-dependent patients carrying the T allele of a functional variant in ALDH5A1 had a greater risk of being nonresponders to methadone maintenance treatment

  4. The strongest association signal arose from an intronic region of the gene ALDH5A1, which encodes the mitochondrial enzyme succinic semialdehyde dehydrogenase (SSADH), an enzyme involved in gamma-aminobutyric acid metabolism.

  5. Missense mutations of c.527G>A and c.691G>A in the ALDH5A1 gene are associated with pathogenesis of succinic semialdehyde dehydrogenase deficiency.

  6. Succinic semialdehyde dehydrognase deficiency is caused by a mutation of the Aldh5a1-gene resulting in a dysfunction of the enzyme succinic semialdehyde dehydrogenase--{REVIEW}

  7. our study identified a novel homozygous ALDH5A1 gene mutation associated with SSADH deficiency.

  8. Study seeks to determine whether cerebellar abnormalities are present in human succinic semialdehyde dehydrogenase deficiency on volumetric MRI (show C7ORF49 Antibodies), compared with radiographic and histologic studies in the mouse model.

  9. the duplication (6)(p22.2) and corresponding hyperactive level of SSADH activity may have negative consequences for GABA metabolism

  10. This study indicated that global disruption of cortical networks in SSADH KO mice, affecting both excitatory and inhibitory neurons.

Mouse (Murine) Aldehyde Dehydrogenase 5 Family, Member A1 (ALDH5A1) interaction partners

  1. These data show that enhanced, rather than compromised, GABA(A) receptor-mediated inhibition occurs in cortico-thalamic networks of SSADH(-/-) mice.

  2. Normal SSADH activity in the Canavan disease (CD) mouse brain suggests that mental retardation and hypotonia seen in the CD mouse is not due to SSADH activity.

  3. murine succinate semialdehyde dehydrogenase has a role in regulating myelin expression

  4. Although our results suggest hippocampal and cortical dysfunction in Aldh5a1 (show ALDH4A1 Antibodies)(-/-) brain, we found no evidence that accumulating key metabolites of SSADH deficiency directly induce impairment of energy metabolism.

  5. SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex

ALDH5A1 Antigen Profile

Protein Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with ALDH5A1

  • aldehyde dehydrogenase 5 family, member A1 (ALDH5A1) antibody
  • aldehyde dehydrogenase 5 family, member A1 (aldh5a1) antibody
  • aldehyde dehydrogenase 5 family, member A1 (Aldh5a1) antibody
  • aldhehyde dehydrogenase family 5, subfamily A1 (Aldh5a1) antibody
  • 6330403E24Rik antibody
  • Ahd-1 antibody
  • Ahd1 antibody
  • D630032B01Rik antibody
  • OTTMUSG00000000613 antibody
  • Ssadh antibody
  • SSDH antibody
  • Ssdh1 antibody

Protein level used designations for ALDH5A1

NAD(+)-dependent succinic semialdehyde dehydrogenase , aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) , aldehyde dehydrogenase 5A1 , aldehyde dehydrogenase family 5 member A1 , succinate-semialdehyde dehydrogenase, mitochondrial , succinic semialdehyde dehydrogenase , aldehyde dehydrogenase 5 family, member A1 , mitochondrial succinate semialdehyde dehydrogenase , aldehyde dehydrogenase family 5, subfamily A1 , aldehyde dehydrogenase 1, mitochondrial

GENE ID SPECIES
449515 Pan troglodytes
488246 Canis lupus familiaris
707902 Macaca mulatta
100216127 Xenopus (Silurana) tropicalis
532724 Bos taurus
100351836 Oryctolagus cuniculus
7915 Homo sapiens
291133 Rattus norvegicus
214579 Mus musculus
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