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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). Additionally we are shipping ALPL Kits (40) and ALPL Proteins (16) and many more products for this protein.
Showing 10 out of 222 products:
Human Polyclonal ALPL Primary Antibody for IHC (p), WB - ABIN3044314
Feng, Zhu, Zhang, Jia, Cheng, Ding, Zhu et al.: Amelioration of compound 4,4'-diphenylmethane-bis(methyl)carbamate on high mobility group box1-mediated inflammation and oxidant stress responses in human umbilical vein endothelial cells via ... in International immunopharmacology 2013
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Human Monoclonal ALPL Primary Antibody for FACS - ABIN4898136
Eshel, Sharabi-Nov, Dally: Leukocyte alkaline phosphatase (LAP) by flow cytometry. in MLO: medical laboratory observer 2013
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Human Polyclonal ALPL Primary Antibody for EIA, WB - ABIN356989
Panuccio, Cutrupi, Pizzini, Mallamaci, Tripepi, Zoccali: Neuropeptide Y and markers of osteoblast activity in dialysis patients: a cross-sectional study. in American journal of kidney diseases : the official journal of the National Kidney Foundation 2007
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Human Monoclonal ALPL Primary Antibody for FACS, ICC - ABIN4900651
Pytlík, Stehlík, Soukup, Kalbácová, Rypácek, Trc, Mulinková, Michnová, Kideryová, Zivný, Klener, Veselá, Trnený, Klener: The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering. in Biomaterials 2009
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Human Monoclonal ALPL Primary Antibody for EIA, FACS - ABIN1105293
Kannampuzha, Tupy, Pritzker: Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution. in The Journal of rheumatology 2009
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Human Polyclonal ALPL Primary Antibody for IHC (p), WB - ABIN1105292
Fedde, Whyte: Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5'-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study. in American journal of human genetics 1990
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Human Monoclonal ALPL Primary Antibody for FACS, IHC - ABIN969500
Kanazawa, Yamaguchi, Yamamoto, Yamauchi, Yano, Sugimoto: Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes. in Calcified tissue international 2009
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Human Monoclonal ALPL Primary Antibody for FACS - ABIN4898128
Klim, Li, Wrighton, Piekarczyk, Kiessling: A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. in Nature methods 2010
Cat (Feline) Monoclonal ALPL Primary Antibody for ICC, FACS - ABIN153427
Chou, Gu, Gao, Dowey, Wang, Shi, Li, Ye, Cheng, Cheng: A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach. in Stem cells translational medicine 2015
Mouse (Murine) Polyclonal ALPL Primary Antibody for FACS, ICC - ABIN4899354
Liedert, Mattausch, Röntgen, Blakytny, Vogele, Pahl, Bindl, Neunaber, Schinke, Harroch, Amling, Ignatius: Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading. in Bone 2011
Preoperative calcitonin (show CALCA Antibodies) levels were correlated with the presence of tumor, whereas alkaline phosphatase (ALP) levels were not. There were no significant associations between tumor volume and ALP (show ALP Antibodies) or calcitonin (show CALCA Antibodies) levels in the preoperative or postoperative periods. During long-term follow-up, serum ALP (show ALP Antibodies) was significantly associated with tumor recurrence, but serum calcitonin (show CALCA Antibodies) was not.
His ALPL gene mutation came from c.228delG mutation in his mother and c.407G>A compound heterozygous mutation in his father
Both PPARgamma (show PPARG Antibodies) gene expression and TNALP activity increased during intracellular lipid accumulation in HepG2 and 3T3-L1 cells. Inhibition of TNALP blocked intracellular lipid accumulation but did not alter expression of the PPARgamma (show PPARG Antibodies) gene.
ALPL is a major contributor to the pathogenesis of Prostate cancer progression.
ALPL expression is significantly upregulated in human masticatory mucosa during wound healing
serum ALP (show ALP Antibodies) levels were not associated with increased death risk in prevalent HD patients over a 5-year interval.
In conclusion, serum levels of BSP (show KLK6 PLURAL_@3975@), ALP (show ALP PLURAL_@3975@), ICTP, and PSA (show PLAG1 PLURAL_@3975@) increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.
results reveal that the amino acid substitutions at position 426 of TNSALP differentially affect the structure and function of TNSALP, leading to understanding of the molecular and cellular basis of hypophosphatasia.
One-half of adult individuals with unexplained low serum ALP (show ALP Antibodies) carried an ALPL mutation. The presence of a mutated allele was associated with tooth loss, slightly lower levels of serum ALP (show ALP Antibodies), higher levels of pyridoxal phosphate and phosphoethanolamine, as well as mildly increased serum phosphate.
Dynamic changes of ALP (show ALP PLURAL_@3975@), LDH and PSA (show PLAG1 PLURAL_@3975@) during Abiraterone-therapy are associated with best clinical benefit and OS in bone metastatic castration resistant prostate cancer
Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (show MBD4 Antibodies) plays role in enamel formation; Med1 (show MBD4 Antibodies) induces Alpl via stimulation of Notch1 (show NOTCH1 Antibodies) signaling by forming Notch1 (show NOTCH1 Antibodies)-RBP-Jk (show RBPJ Antibodies) complex on Alpl promoter. (Med1 (show MBD4 Antibodies) = mediator complex subunit 1 (show MED1 Antibodies); Alpl = alkaline phosphatase, liver-bone-kidney; Notch1 (show NOTCH1 Antibodies) = Notch gene homolog 1 (show NOTCH1 Antibodies); RBP-Jk (show RBPJ Antibodies) = kappa J region recombining binding protein suppressor of hairless (show RBPJ Antibodies))
These analyses revealed that TNAP deficient mice present an increased proliferation of neural precursors, an altered neuronal morphology, and an augmented neuronal activity. We found that these alterations were associated with a partial downregulation of the purinergic P2X7 receptor (P2X7R (show P2RX7 Antibodies)).
Despite similar deficiencies in alkaline phosphatase, Alpl(-/-) mice develop craniosynostosis and a brachycephalic/acrocephalic craniofacial shape of variable penetrance.
Prevention of lethal murine hypophosphatasia by neonatal ex vivo gene therapy using lentivirally transduced bone marrow cells expressing Akp-2.
TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.
In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2 (show SFRP2 Antibodies).
p107 (show RBL1 Antibodies) is required for the efficient recruitment of an activating SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) chromatin-remodeling complex, an essential event in Alpl induction.
Inhibition of rhBMP-2-induced ALP (show CCL21A Antibodies) activity by intracellular delivery of SMURF1 (show SMURF1 Antibodies) in murine calvarial preosteoblast cells.
Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP (show HPR Antibodies), including true bony craniosynostosis in the context of severely diminished bone mineralization
CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP (show TMPRSS5 Antibodies) in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine.
The peri (show PLIN1 Antibodies)-partum characteristics of serum bone-specific alkaline phosphatase (BAP (show PHB2 Antibodies)) and urinary deoxypyridinoline (DPD (show DPYD Antibodies)) in dairy cattle are reported.
GPI (show GPI Antibodies)-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
tissue-nonspecific alkaline phosphatase
, alkaline phosphatase, tissue-nonspecific isozyme
, tissue non-specific alkaline phosphatase
, alkaline phosphatase, liver/bone/kidney
, alkaline phosphatase, tissue-nonspecific isozyme-like
, alkaline phosphatase liver/bone/kidney isozyme
, alkaline phosphomonoesterase
, liver/bone/kidney-type alkaline phosphatase
, tissue-nonspecific ALP
, alkaline phosphatase 2, liver
, Tissue-nonspecific ALP alkaline phosphatase
, alkaline phosphatase tissue non-specific isoform
, liver/bone/kidney isozyme