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anti-Alkaline Phosphatase, Liver/bone/kidney (ALPL) Antibodies

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). Additionally we are shipping ALPL Kits (37) and ALPL Proteins (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ALPL 249 P05186
ALPL 11647 P09242
ALPL 25586 P08289
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Top anti-ALPL Antibodies at antibodies-online.com

Showing 10 out of 220 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemical analysis of paraffin embedded rat tissue sections (small intestine), staining ALPL in cytoplasm, DAB chromogenic reaction Western blot analysis of Hela cell tissue lysis using ALPL antibody 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, FACS, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$423.50
Details
Cat Mouse Un-conjugated ICC, FACS, IF, IP Flow Cytometry: Alkaline Phosphatase, Tissue Non-Specific Antibody (TRA-2-49) [ABIN153427] - Analysis using anti-TRA-2-49. 2102Ep cells were stained with anti-TRA-2-49 antibody (Green) or isotype control antibody (grey). 0.05 mg Log in to see 7 to 9 Days
$408.19
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of MCF-7 cells using ALPL mouse mAb (green) and negative control (red) . 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Mouse PE FACS Detection of Alkaline Phosphatase/ALPL in BG01V Human Cells by Flow Cytometry. BG01V human embryonic stem cells were stained with Mouse Anti-Human Alkaline Phosphatase/ALPL PE-conjugated Monoclonal Antibody. 25 Tests Log in to see 8 to 9 Days
$189.00
Details
Human Mouse Allophycocyanin FACS Detection of Alkaline Phosphatase/ALPL in BG01V Human Cells by Flow Cytometry. BG01V human embryonic stem cells were stained with Mouse Anti-Human Alkaline Phosphatase/ALPL APC-conjugated Monoclonal Antibody. 25 Tests Log in to see 8 to 9 Days
$210.00
Details
Human Mouse Biotin FACS, ICC, IHC Alkaline Phosphatase/ALPL in Human Osteoblasts. 100 μg Log in to see 8 to 9 Days
$266.70
Details
Mouse Goat Un-conjugated FACS, ICC, IHC, IP, WB Detection of ALPL in Rat Stem Cells by Flow Cytometry. Alkaline Phosphatase/ALPL in Rat Mesenchymal Stem Cells. Alkaline Phosphatase/ALPL was detected in immersion fixed rat mesenchymal stem cells using Goat Anti-Mouse Alkaline Phosphatase/ALPL Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cell surfaces and cytoplasm. 100 μg Log in to see 8 to 9 Days
$372.75
Details
Human Mouse Un-conjugated FACS, ICC, IHC Detection of Alkaline Phosphatase/ALPL in BG01V Human Cells by Flow Cytometry. BG01V human embryonic stem cells was stained with Mouse Anti-Human Alkaline Phosphatase/ALPL Monoclonal Antibody. Alkaline Phosphatase and Oct-3/4 in BG01V Human Stem Cells. Alkaline Phosphatase/ALPL and Oct-3/4 were detected in human BG01V embryonic stem cells using 10 ug/mL Mouse Anti-Human Alkaline Phosphatase/ALPL Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$276.15
Details

ALPL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ALPL Antibodies

  1. Human Monoclonal ALPL Primary Antibody for FACS - ABIN4898136 : Eshel, Sharabi-Nov, Dally: Leukocyte alkaline phosphatase (LAP) by flow cytometry. in MLO: medical laboratory observer 2013 (PubMed)
    Show all 3 references for ABIN4898136

  2. Human Polyclonal ALPL Primary Antibody for EIA, WB - ABIN356989 : Panuccio, Cutrupi, Pizzini, Mallamaci, Tripepi, Zoccali: Neuropeptide Y and markers of osteoblast activity in dialysis patients: a cross-sectional study. in American journal of kidney diseases : the official journal of the National Kidney Foundation 2007 (PubMed)
    Show all 3 references for ABIN356989

  3. Human Polyclonal ALPL Primary Antibody for IHC (p), WB - ABIN1105292 : Fedde, Whyte: Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5'-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study. in American journal of human genetics 1990 (PubMed)
    Show all 2 references for ABIN1105292

  4. Human Monoclonal ALPL Primary Antibody for FACS, ICC - ABIN4900651 : Pytlík, Stehlík, Soukup, Kalbácová, Rypácek, Trc, Mulinková, Michnová, Kideryová, Zivný, Klener, Veselá, Trnený, Klener: The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering. in Biomaterials 2009 (PubMed)
    Show all 2 references for ABIN4900651

  5. Human Monoclonal ALPL Primary Antibody for FACS, IHC - ABIN969500 : Kannampuzha, Tupy, Pritzker: Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution. in The Journal of rheumatology 2009 (PubMed)
    Show all 2 references for ABIN969500

  6. Human Monoclonal ALPL Primary Antibody for EIA, FACS - ABIN1105293 : Kanazawa, Yamaguchi, Yamamoto, Yamauchi, Yano, Sugimoto: Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes. in Calcified tissue international 2009 (PubMed)
    Show all 2 references for ABIN1105293

  7. Cat (Feline) Monoclonal ALPL Primary Antibody for ICC, FACS - ABIN153427 : Chou, Gu, Gao, Dowey, Wang, Shi, Li, Ye, Cheng, Cheng: A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach. in Stem cells translational medicine 2015 (PubMed)

  8. Human Polyclonal ALPL Primary Antibody for ELISA, WB - ABIN1451976 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)

  9. Human Monoclonal ALPL Primary Antibody for FACS - ABIN4898128 : Klim, Li, Wrighton, Piekarczyk, Kiessling: A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. in Nature methods 2010 (PubMed)

More Antibodies against ALPL Interaction Partners

Human Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. ALPL expression is significantly upregulated in human masticatory mucosa during wound healing

  2. serum ALP (show ALP Antibodies) levels were not associated with increased death risk in prevalent HD patients over a 5-year interval.

  3. In conclusion, serum levels of BSP (show KLK6 Antibodies), ALP (show ALP Antibodies), ICTP, and PSA (show PLAG1 Antibodies) increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.

  4. results reveal that the amino acid substitutions at position 426 of TNSALP differentially affect the structure and function of TNSALP, leading to understanding of the molecular and cellular basis of hypophosphatasia.

  5. One-half of adult individuals with unexplained low serum ALP (show ALP Antibodies) carried an ALPL mutation. The presence of a mutated allele was associated with tooth loss, slightly lower levels of serum ALP (show ALP Antibodies), higher levels of pyridoxal phosphate and phosphoethanolamine, as well as mildly increased serum phosphate.

  6. Dynamic changes of ALP (show ALP Antibodies), LDH and PSA (show PLAG1 Antibodies) during Abiraterone-therapy are associated with best clinical benefit and OS in bone metastatic castration resistant prostate cancer

  7. Analysis of a series of multiple N-glycan depletion mutants in TNSALP revealed that three N-glycans on N230, N271 and N303 were the minimal requirement for the structure and function of TNSALP and a prerequisite for its stable expression in a cell.

  8. The presence of TNAP increased the dynamics and decreased the ordering of model membranes.

  9. These data confirm that TNAP is co-expressed by dental pulp stromal cells together with other bone marrow stromal cells markers and show that cell density affects TNAP expression levels.

  10. ALP (show ALP Antibodies) quartiles were significantly associated with albuminuria in participants with estimated glomerular filtration rate>120 90-119, 60-89 and <60 mL/min/1.73 Higher ALP (show ALP Antibodies) levels are significantly associated with renal hyperfiltration

Mouse (Murine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. Despite similar deficiencies in alkaline phosphatase, Alpl(-/-) mice develop craniosynostosis and a brachycephalic/acrocephalic craniofacial shape of variable penetrance.

  2. Prevention of lethal murine hypophosphatasia by neonatal ex vivo gene therapy using lentivirally transduced bone marrow cells expressing Akp-2.

  3. TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.

  4. In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2 (show SFRP2 Antibodies).

  5. p107 (show RBL1 Antibodies) is required for the efficient recruitment of an activating SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) chromatin-remodeling complex, an essential event in Alpl induction.

  6. Inhibition of rhBMP-2-induced ALP (show CCL21A Antibodies) activity by intracellular delivery of SMURF1 (show SMURF1 Antibodies) in murine calvarial preosteoblast cells.

  7. Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP (show HPR Antibodies), including true bony craniosynostosis in the context of severely diminished bone mineralization

  8. CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP (show TMPRSS5 Antibodies) in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine.

  9. TNAP plays a role in governing the phosphorylation status of phospholamban (show PLN Antibodies) in the sarcoplasmic reticulum.

  10. Taken together, these data indicate that ATF3 (show ATF3 Antibodies) is a novel negative regulator of osteoblast differentiation by specifically suppressing ALP (show CCL21A Antibodies) gene expression in preosteoblasts.

Cow (Bovine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. The peri (show PLIN1 Antibodies)-partum characteristics of serum bone-specific alkaline phosphatase (BAP (show PHB2 Antibodies)) and urinary deoxypyridinoline (DPD (show DPYD Antibodies)) in dairy cattle are reported.

  2. GPI (show GPI Antibodies)-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.

ALPL Antigen Profile

Protein Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ALPL

  • alkaline phosphatase, liver/bone/kidney (alpl) antibody
  • alkaline phosphatase, liver/bone/kidney (ALPL) antibody
  • alkaline phosphatase, intestinal, gene 2 (alpi.2) antibody
  • alkaline phosphatase, liver/bone/kidney (Alpl) antibody
  • Akp-2 antibody
  • Akp2 antibody
  • ALP antibody
  • alpl antibody
  • AP-TNAP antibody
  • APTNAP antibody
  • HOPS antibody
  • iap antibody
  • PHOA antibody
  • TNAP antibody
  • TNS-AP antibody
  • TNSALP antibody

Protein level used designations for ALPL

tissue-nonspecific alkaline phosphatase , alkaline phosphatase, tissue-nonspecific isozyme , tissue non-specific alkaline phosphatase , alkaline phosphatase, liver/bone/kidney , alkaline phosphatase, tissue-nonspecific isozyme-like , alkaline phosphatase liver/bone/kidney isozyme , alkaline phosphomonoesterase , glycerophosphatase , liver/bone/kidney-type alkaline phosphatase , tissue-nonspecific ALP , alkaline phosphatase 2, liver , AP-TNAP , TNSALP , Tissue-nonspecific ALP alkaline phosphatase , alkaline phosphatase tissue non-specific isoform , liver/bone/kidney isozyme

GENE ID SPECIES
380589 Xenopus laevis
403548 Canis lupus familiaris
717809 Macaca mulatta
100144722 Xenopus (Silurana) tropicalis
100401643 Callithrix jacchus
100440770 Pongo abelii
100031702 Monodelphis domestica
456600 Pan troglodytes
100602436 Nomascus leucogenys
249 Homo sapiens
11647 Mus musculus
25586 Rattus norvegicus
280994 Bos taurus
100170147 Sus scrofa
727689 Felis catus
396317 Gallus gallus
101123195 Ovis aries
Selected quality suppliers for anti-ALPL (ALPL) Antibodies
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