anti-Alkaline Phosphatase, Liver/bone/kidney (ALPL) Antibodies

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). Additionally we are shipping ALPL Kits (43) and ALPL Proteins (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ALPL 249 P05186
ALPL 11647 P09242
ALPL 25586 P08289
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Top anti-ALPL Antibodies at antibodies-online.com

Showing 10 out of 236 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemical analysis of paraffin embedded rat tissue sections (small intestine), staining ALPL in cytoplasm, DAB chromogenic reaction Western blot analysis of Hela cell tissue lysis using ALPL antibody 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Alkaline Phosphatase antibody, IHC(P) IHC(P): Rat Small Intestine Tissue All lanes: Anti ALPL () at 0.5ug/ml Lane 1: Human Placenta Tissue Lysate at 50ug Lane 2:  Whole Cell Lysate at 40ug Lane 3: JURKAT Whole Cell Lysate at 40ug Predicted bind size: 57KD Observed bind size: 57KD 100 μg Log in to see 4 to 6 Days
$200.00
Details
Cat Mouse Un-conjugated ICC, FACS, IF, IP Flow Cytometry: Alkaline Phosphatase, Tissue Non-Specific Antibody (TRA-2-49) [ABIN153427] - Analysis using anti-TRA-2-49. 2102Ep cells were stained with anti-TRA-2-49 antibody (Green) or isotype control antibody (grey). 0.05 mg Log in to see 7 to 9 Days
$408.19
Details
Mouse Goat Un-conjugated CyTOF, FACS, ICC, IHC, IP, WB Detection of ALPL in Rat Stem Cells by Flow Cytometry. Alkaline Phosphatase/ALPL in Rat Mesenchymal Stem Cells. Alkaline Phosphatase/ALPL was detected in immersion fixed rat mesenchymal stem cells using Goat Anti-Mouse Alkaline Phosphatase/ALPL Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cell surfaces and cytoplasm. 100 μg Log in to see 8 to 9 Days
$372.75
Details
Human Mouse PE FACS Detection of Alkaline Phosphatase/ALPL in BG01V Human Cells by Flow Cytometry. BG01V human embryonic stem cells were stained with Mouse Anti-Human Alkaline Phosphatase/ALPL PE-conjugated Monoclonal Antibody. Detection of Alkaline Phosphatase/ALPL in BG01V Human Cells by Flow Cytometry. BG01V human embryonic stem cells were stained with Mouse Anti-Human Alkaline Phosphatase/ALPL PE-conjugated Monoclonal Antibody. 25 Tests Log in to see 8 to 9 Days
$189.00
Details
Human Mouse Allophycocyanin FACS Detection of Alkaline Phosphatase/ALPL in BG01V Human Cells by Flow Cytometry. BG01V human embryonic stem cells were stained with Mouse Anti-Human Alkaline Phosphatase/ALPL APC-conjugated Monoclonal Antibody. Detection of Alkaline Phosphatase/ALPL in BG01V Human Cells by Flow Cytometry. BG01V human embryonic stem cells were stained with Mouse Anti-Human Alkaline Phosphatase/ALPL APC-conjugated Monoclonal Antibody. 25 Tests Log in to see 8 to 9 Days
$210.00
Details
Human Mouse Biotin FACS, ICC, IHC Alkaline Phosphatase/ALPL in Human Osteoblasts. Alkaline Phosphatase/ALPL in Human Osteoblasts. 100 μg Log in to see 8 to 9 Days
$266.70
Details
Human Mouse Un-conjugated CyTOF, FACS, ICC, IHC Detection of Alkaline Phosphatase/ALPL in BG01V Human Cells by Flow Cytometry. BG01V human embryonic stem cells was stained with Mouse Anti-Human Alkaline Phosphatase/ALPL Monoclonal Antibody. Alkaline Phosphatase and Oct-3/4 in BG01V Human Stem Cells. Alkaline Phosphatase/ALPL and Oct-3/4 were detected in human BG01V embryonic stem cells using 10 ug/mL Mouse Anti-Human Alkaline Phosphatase/ALPL Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$276.15
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of MCF-7 cells using ALPL mouse mAb (green) and negative control (red) . 100 μg Log in to see 2 to 3 Days
$430.10
Details

ALPL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ALPL Antibodies

  1. Human Polyclonal ALPL Primary Antibody for WB - ABIN5518640 : Feng, Zhu, Zhang, Jia, Cheng, Ding, Zhu et al.: Amelioration of compound 4,4'-diphenylmethane-bis(methyl)carbamate on high mobility group box1-mediated inflammation and oxidant stress responses in human umbilical vein endothelial cells via ... in International immunopharmacology 2013 (PubMed)
    Show all 18 Pubmed References

  2. Rat (Rattus) Polyclonal ALPL Primary Antibody for WB - ABIN5518639 : Li, Xia, Tang, Wang, Bei, Zeng: In vitro and in vivo biocompatibility investigation of diamond-like carbon coated nickel-titanium shape memory alloy. in Artificial cells, blood substitutes, and immobilization biotechnology 2011 (PubMed)
    Show all 18 Pubmed References

  3. Human Polyclonal ALPL Primary Antibody for IHC (p), WB - ABIN3044314 : Xu, Dong, Huang, Li, Qin, Ren, Guo, Chen, Huang: Decreased osteoclastogenesis, osteoblastogenesis and low bone mass in a mouse model of type 2 diabetes. in Molecular medicine reports 2014 (PubMed)
    Show all 18 Pubmed References

  4. Human Monoclonal ALPL Primary Antibody for CyTOF, FACS - ABIN4900675 : Wang, Zhao, Shi, Wei, Halloran, Clark, Jacobs, Kingery: Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. in Bone 2009 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal ALPL Primary Antibody for FACS - ABIN4898137 : Ramirez, Gerbal-Chaloin, Milhavet, Qiang, Becker, Assou, Lemaître, Hamamah, De Vos: Brief report: benchmarking human pluripotent stem cell markers during differentiation into the three germ layers unveils a striking heterogeneity: all markers are not equal. in Stem cells (Dayton, Ohio) 2011 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal ALPL Primary Antibody for FACS - ABIN4898136 : Eshel, Sharabi-Nov, Dally: Leukocyte alkaline phosphatase (LAP) by flow cytometry. in MLO: medical laboratory observer 2013 (PubMed)
    Show all 3 Pubmed References

  7. Human Monoclonal ALPL Primary Antibody for FACS, ICC - ABIN4900651 : Pytlík, Stehlík, Soukup, Kalbácová, Rypácek, Trc, Mulinková, Michnová, Kideryová, Zivný, Klener, Veselá, Trnený, Klener: The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering. in Biomaterials 2009 (PubMed)
    Show all 2 Pubmed References

  8. Human Monoclonal ALPL Primary Antibody for FACS, IHC - ABIN969500 : Kannampuzha, Tupy, Pritzker: Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution. in The Journal of rheumatology 2009 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal ALPL Primary Antibody for FACS, IF - ABIN5572435 : Moss: Diagnostic aspects of alkaline phosphatase and its isoenzymes. in Clinical biochemistry 1988 (PubMed)

  10. Cat (Feline) Monoclonal ALPL Primary Antibody for ICC, FACS - ABIN153427 : Chou, Gu, Gao, Dowey, Wang, Shi, Li, Ye, Cheng, Cheng: A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach. in Stem cells translational medicine 2015 (PubMed)

More Antibodies against ALPL Interaction Partners

Human Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. These results show that an increase of TNAP activity in ACDC (arterial calcification due to deficiency of CD73) contributes to ectopic calcification by disrupting the extracellular balance of PPi and Pi and identify potential therapeutic targets for ACDC.

  2. the identification of 11 novel ALPL mutations in the five different HPP (show SPTA1 Antibodies) forms and the observation of a recurrent mutation, p. (Thr166Ile) in the Spanish population expand our knowledge of pathogenic ALPL mutations.

  3. Preoperative calcitonin (show CALCA Antibodies) levels were correlated with the presence of tumor, whereas alkaline phosphatase (ALP) levels were not. There were no significant associations between tumor volume and ALP (show ALP Antibodies) or calcitonin (show CALCA Antibodies) levels in the preoperative or postoperative periods. During long-term follow-up, serum ALP (show ALP Antibodies) was significantly associated with tumor recurrence, but serum calcitonin (show CALCA Antibodies) was not.

  4. His ALPL gene mutation came from c.228delG mutation in his mother and c.407G>A compound heterozygous mutation in his father

  5. Both PPARgamma (show PPARG Antibodies) gene expression and TNALP activity increased during intracellular lipid accumulation in HepG2 and 3T3-L1 cells. Inhibition of TNALP blocked intracellular lipid accumulation but did not alter expression of the PPARgamma (show PPARG Antibodies) gene.

  6. ALPL is a major contributor to the pathogenesis of Prostate cancer progression.

  7. ALPL expression is significantly upregulated in human masticatory mucosa during wound healing

  8. serum ALP (show ALP Antibodies) levels were not associated with increased death risk in prevalent HD patients over a 5-year interval.

  9. In conclusion, serum levels of BSP, ALP, ICTP, and PSA increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.

  10. results reveal that the amino acid substitutions at position 426 of TNSALP differentially affect the structure and function of TNSALP, leading to understanding of the molecular and cellular basis of hypophosphatasia.

Mouse (Murine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. TNAP overexpression in vascular endothelium in mice leads to an unusual course of coronary atherosclerosis and was accompanied by the reduction in body weight and left ventricular ejection fraction.

  2. Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (show MBD4 Antibodies) plays role in enamel formation; Med1 (show MBD4 Antibodies) induces Alpl via stimulation of Notch1 (show NOTCH1 Antibodies) signaling by forming Notch1 (show NOTCH1 Antibodies)-RBP-Jk (show RBPJ Antibodies) complex on Alpl promoter. (Med1 (show MBD4 Antibodies) = mediator complex subunit 1 (show MED1 Antibodies); Alpl = alkaline phosphatase, liver-bone-kidney; Notch1 (show NOTCH1 Antibodies) = Notch gene homolog 1 (show NOTCH1 Antibodies); RBP-Jk (show RBPJ Antibodies) = kappa J region recombining binding protein suppressor of hairless (show RBPJ Antibodies))

  3. These analyses revealed that TNAP deficient mice present an increased proliferation of neural precursors, an altered neuronal morphology, and an augmented neuronal activity. We found that these alterations were associated with a partial downregulation of the purinergic P2X7 receptor (P2X7R (show P2RX7 Antibodies)).

  4. Despite similar deficiencies in alkaline phosphatase, Alpl(-/-) mice develop craniosynostosis and a brachycephalic/acrocephalic craniofacial shape of variable penetrance.

  5. Prevention of lethal murine hypophosphatasia by neonatal ex vivo gene therapy using lentivirally transduced bone marrow cells expressing Akp-2.

  6. TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.

  7. In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2 (show SFRP2 Antibodies).

  8. p107 (show RBL1 Antibodies) is required for the efficient recruitment of an activating SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) chromatin-remodeling complex, an essential event in Alpl induction.

  9. Inhibition of rhBMP-2-induced ALP (show CCL21A Antibodies) activity by intracellular delivery of SMURF1 (show SMURF1 Antibodies) in murine calvarial preosteoblast cells.

  10. Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP (show HPR Antibodies), including true bony craniosynostosis in the context of severely diminished bone mineralization

Cow (Bovine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. The peri (show PLIN1 Antibodies)-partum characteristics of serum bone-specific alkaline phosphatase (BAP (show PHB2 Antibodies)) and urinary deoxypyridinoline (DPD (show DPYD Antibodies)) in dairy cattle are reported.

  2. GPI (show GPI Antibodies)-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.

ALPL Antigen Profile

Protein Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ALPL

  • alkaline phosphatase, liver/bone/kidney L homeolog (alpl.L) antibody
  • alkaline phosphatase, liver/bone/kidney (ALPL) antibody
  • alkaline phosphatase, intestinal, gene 2 (alpi.2) antibody
  • alkaline phosphatase, liver/bone/kidney pseudogene (LOC100031702) antibody
  • alkaline phosphatase, liver/bone/kidney (Alpl) antibody
  • Akp-2 antibody
  • Akp2 antibody
  • ALP antibody
  • alpl antibody
  • AP-TNAP antibody
  • APTNAP antibody
  • HOPS antibody
  • iap antibody
  • PHOA antibody
  • TNAP antibody
  • TNS-AP antibody
  • TNSALP antibody

Protein level used designations for ALPL

tissue-nonspecific alkaline phosphatase , alkaline phosphatase, tissue-nonspecific isozyme , tissue non-specific alkaline phosphatase , alkaline phosphatase, liver/bone/kidney , alkaline phosphatase, tissue-nonspecific isozyme-like , alkaline phosphatase liver/bone/kidney isozyme , alkaline phosphomonoesterase , glycerophosphatase , liver/bone/kidney-type alkaline phosphatase , tissue-nonspecific ALP , alkaline phosphatase 2, liver , AP-TNAP , TNSALP , Tissue-nonspecific ALP alkaline phosphatase , alkaline phosphatase tissue non-specific isoform , liver/bone/kidney isozyme

GENE ID SPECIES
380589 Xenopus laevis
403548 Canis lupus familiaris
717809 Macaca mulatta
100144722 Xenopus (Silurana) tropicalis
100401643 Callithrix jacchus
100440770 Pongo abelii
100031702 Monodelphis domestica
456600 Pan troglodytes
100602436 Nomascus leucogenys
249 Homo sapiens
11647 Mus musculus
25586 Rattus norvegicus
280994 Bos taurus
100170147 Sus scrofa
727689 Felis catus
396317 Gallus gallus
101123195 Ovis aries
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