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Amiloride-Sensitive Cation Channel 3 Proteins (ACCN3)

ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Additionally we are shipping Amiloride-Sensitive Cation Channel 3 Antibodies (49) and Amiloride-Sensitive Cation Channel 3 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ACCN3 ACCN3 286920 O35240
ACCN3 9311 Q9UHC3
ACCN3 171209 Q6X1Y6
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Top Amiloride-Sensitive Cation Channel 3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

ACCN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for Amiloride-Sensitive Cation Channel 3 (ACCN3) Interaction Partners

Horse (Equine) Amiloride-Sensitive Cation Channel 3 (ACCN3) interaction partners

  1. Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (show ACCN1 Proteins) differential properties; ACCN1 (show ACCN2 Proteins) and ACCN3 genes have an ubiquitous expression but ACCN1 (show ACCN2 Proteins) is more highly expressed in the spinal cord.

Human Amiloride-Sensitive Cation Channel 3 (ACCN3) interaction partners

  1. Blocking ASIC3 in interneurons from temporal lobe epilepsy patients decreased the frequency of action potential firing.

  2. These findings open new perspectives on the roles of ASIC3 in the absence of tissue pH variation, as well as on the contribution of those channels to lipid-mediated signaling.

  3. Sea (show Slc25a1 Proteins) anemone peptide with uncommon beta-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity.

  4. Experiments with Asic3 inhibitors show that Asic3 inhibition leads to loss of pressure-induced vasodilation due to pressure detection failure rather than endothelial mechanisms.

  5. The highly proton sensitive ASIC3 channels are predominantly distributed in peripheral sensory neurons, correlating with their roles in multimodal sensory perception, including nociception, mechanosensation, and chemosensation.

  6. CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95 (show DLG4 Proteins).

  7. Lignan from thyme possesses inhibitory effect on ASIC3 channel current.

  8. A mechanism of induction of ASIC-3 expression relevant to AR was suggested by the finding that eosinophil peroxidase (EPO (show EPX Proteins)), acting via ERK1/2, induced the expression of ASIC-3 in epithelial cells.

  9. ASIC3 is able to sense the extracellular pH in both directions and to dynamically adapt its activity between pH 5.0 and 8.0, playing a role in fine tuning neuronal membrane potentials and neuron sensitization in various pH environments.

  10. The results showed that there was a significant increase in the mean relative optical density of ASIC2 (show ACCN1 Proteins) and ASIC3 but not ASIC1a (show ACCN2 Proteins) in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura.

Mouse (Murine) Amiloride-Sensitive Cation Channel 3 (ACCN3) interaction partners

  1. ASIC3 is critical for scratching behavior and pathological changes in chronic itch.

  2. Data suggest that activation of acid-sensing ion channel 3 (ASIC3) on fibroblast-like synoviocytes (FLS) by acidic pH from an inflamed joint could limit synovial proliferation resulting in reduced inflammatory mediators and subsequent joint damage.

  3. we unraveled an important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli.

  4. The activation of asic3 activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain.

  5. Sea (show Slc25a1 Proteins) anemone peptide with uncommon beta-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity.

  6. Local pressure induced vasodilation in Asic3+/+ but not Asic3-/- mice, in which high pressure caused ischemia & ulcers.

  7. Responses of glomus cells to hypoxia and acidosis are uncoupled, reciprocal and linked to ASIC3 expression

  8. Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis.

  9. The results of this study identify ASIC3 channels as an unexpected molecular target for acute actions of 5-HT (show DDC Proteins) in inflammatory pain sensation.

  10. Currents from ASIC1a (show ACCN2 Proteins)(-/-) muscle afferents were less pH-sensitive and displayed faster recovery, currents from ASIC2 (show ACCN1 Proteins)(-/-) showed diminished potentiation by zinc, and currents from ASIC3(-/-) displayed slower desensitization than those from wild-type.

Amiloride-Sensitive Cation Channel 3 (ACCN3) Protein Profile

Protein Summary

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ACCN3

  • amiloride-sensitive cation channel 3 (ACCN3)
  • amiloride-sensitive cation channel 3 (LOC100350503)
  • acid-sensing (proton-gated) ion channel 3 (Asic3)
  • acid-sensing (proton-gated) ion channel 3 (ASIC3)
  • Accn3 protein
  • AW742291 protein
  • DRASIC protein
  • SLNAC1 protein
  • TNAC1 protein

Protein level used designations for ACCN3

amiloride-sensitive cation channel 3 , amiloride-sensitive cation channel 3-like , DRASIC , acid sensing ion channel 3 , acid-sensing ion channel 3 , dorsal root ASIC , proton gated cation channel DRASIC , amiloride-sensitive cation channel 3, testis , modulatory subunit of ASIC2a , neuronal amiloride-sensitive cation channel 3 , proton-gated cation channel subunit , testis sodium channel 1

GENE ID SPECIES
429486 Gallus gallus
100063408 Equus caballus
100350503 Oryctolagus cuniculus
100442058 Pongo abelii
286920 Rattus norvegicus
9311 Homo sapiens
171209 Mus musculus
482801 Canis lupus familiaris
789132 Bos taurus
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