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Amiloride-Sensitive Cation Channel 2, Neuronal Proteins (ACCN2)

ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Additionally we are shipping Amiloride-Sensitive Cation Channel 2, Neuronal Antibodies (103) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ACCN2 ACCN2 79123 P55926
ACCN2 41 P78348
ACCN2 11419 Q6NXK8
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Top Amiloride-Sensitive Cation Channel 2, Neuronal Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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ACCN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
,

More Proteins for Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Interaction Partners

Horse (Equine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (show ACCN1 Proteins) differential properties; ACCN1 and ACCN3 (show ACCN3 Proteins) genes have an ubiquitous expression but ACCN1 is more highly expressed in the spinal cord.

Human Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. The results show that acid-sensing ion channel 1, acid-sensing ion channel 2 (show ACCN1 Proteins), and acid-sensing ion channel 3 (show ACCN3 Proteins) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.

  2. Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling and increased drug resistance, suggesting that ASIC1a/Ca(2 (show CA2 Proteins)+)/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  3. Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.

  4. The C mutated allele for ACCN2 rs685012 polymorphism was more frequent in panic disorder patients. The ACCN2 TT/ADORA2A (show ADORA2A Proteins) CT diplotype were more represented in controls. This suggests a role for ACCN2 rs685012 polymorphism in PD development in Caucasian

  5. analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel

  6. Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The

  7. Putative GABAA (show GABRg1 Proteins) and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.

  8. A novel interaction between ASIC1 and integrin-Beta1, mediated by alpha-actinin (show ACTN1 Proteins) was determined in glioma tumor cells.

  9. ASIC1a opening is accompanied by a distance increase between adjacent thumb and palm domains as well as a movement of Glu (show DCTN1 Proteins)-235 relative to the knuckle helix.

  10. ASIC1A and ENaCalpha (show SCNN1A Proteins) form functional heterotrimers acting as ion channels.

Mouse (Murine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. ASIC1a is an important mediator of AHR (show AHR Proteins).

  2. Ca(2 (show CA2 Proteins)+) influx through ASIC1 mediates chronic hypoxia and ET-1 (show EDN1 Proteins)-induced NFATc3 (show NFATC3 Proteins) nuclear import and 2) the scaffolding protein PICK1 (show PICK1 Proteins) is necessary for NFATc3 (show NFATC3 Proteins) nuclear import.

  3. This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (show GRIN1 Proteins) (mGlu) receptor-induced increase in action potential firing.

  4. the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a (show ACCN1 Proteins) subunits, but not ASIC1b, ASIC3 (show ACCN3 Proteins) subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.

  5. Studies with ASIC1a-ASIC2a (show ACCN1 Proteins) chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys (show DNAJC5 Proteins) residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.

  6. differential surface trafficking of ASIC1a, ASIC2a (show ACCN1 Proteins), and ASIC2b, was investigated.

  7. This study demonstrated that asic1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.

  8. Acid-sensing ion channel 1a drives AMPA (show GRIA3 Proteins) receptor plasticity following ischaemia and acidosis in hippocampal CA1 (show CA1 Proteins) neurons

  9. Deletion of the Asic1a gene significantly prevents RIP1 (show RALBP1 Proteins) phosphorylation and brain damage, suggesting ASIC1a-mediated RIP1 (show RALBP1 Proteins) activation has an important role in ischemic neuronal injury.

  10. Study suggests that ASIC1a activity facilitates NMDAR (show GRIN1 Proteins) function and exacerbates NMDAR (show GRIN1 Proteins)-mediated neuronal death in pathological conditions

Pig (Porcine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.

Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Protein Profile

Protein Summary

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ACCN2

  • amiloride-sensitive cation channel 2, neuronal (ACCN2)
  • acid-sensing (proton-gated) ion channel 2 (ACCN1)
  • Amiloride-sensitive cation channel 2, neuronal (accn2)
  • acid-sensing (proton-gated) ion channel 1 (Asic1)
  • acid-sensing (proton-gated) ion channel 1 (ASIC1)
  • acid-sensing (proton-gated) ion channel 1 (ACCN2)
  • ACCN2 protein
  • AI843610 protein
  • ASIC protein
  • ASIC1 protein
  • ASIC1a protein
  • B530003N02Rik protein
  • BNaC2 protein

Protein level used designations for ACCN2

amiloride-sensitive cation channel 2, neuronal , amiloride-sensitive cation channel 1, neuronal , Amiloride-sensitive cation channel 2, neuronal , BNaC2 , acid-sensing ion channel 1 , brain sodium channel 2 , proton gated cation channel ASIC1 , Cation channel, amiloride-sensitive, neuronal, 2 , acid-sensing ion channel 1a protein , acid sensing ion channel , degenerin 2

GENE ID SPECIES
451888 Pan troglodytes
100058355 Equus caballus
100194955 Salmo salar
100355858 Oryctolagus cuniculus
713320 Macaca mulatta
79123 Rattus norvegicus
41 Homo sapiens
11419 Mus musculus
100517467 Sus scrofa
426883 Gallus gallus
477612 Canis lupus familiaris
538244 Bos taurus
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