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Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) Proteins (APBB1)

The protein encoded by APBB1 is a member of the Fe65 protein family. Additionally we are shipping Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) Antibodies (91) and Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APBB1 11785 Q9QXJ1
APBB1 322 O00213
APBB1 29722 P46933
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Top Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) Proteins at antibodies-online.com

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,073.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

APBB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) Interaction Partners

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) interaction partners

  1. Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling.

  2. results provide strong evidence that Fe65 plays a role in DNA damage response and cell viability by epigenomic regulation of specific transcriptional programs activated upon genotoxic stress.

  3. Findings show that amyloid precursor protein (show APP Proteins)-binding proteins FE65 and FE65L1 (show APBB2 Proteins) are essential for the maintenance of lens transparency.

  4. our data suggest that FE65 serves as a link between VLDLR (show VLDLR Proteins) and APP (show APP Proteins)

  5. FE65 small interfering RNA does not influence Rac1 expression or its activity, although it acts as an adaptor protein with several protein-interaction domains.

  6. Fe65 carries out different functions depending on its location in the regulation of Notch1 (show NOTCH1 Proteins) signaling.

  7. a unique role for the 97 kDa isoform in controlling GnRH-1 (show GNRH1 Proteins) neurogenesis that is not redundant with the 60 kDa isoform of FE65.

  8. Results confirm that megalin (show LRP2 Proteins) interacts with APP (show APP Proteins) and FE65, suggesting that these three proteins form a tripartite complex.

  9. Data show that the carboxyl-terminal half of FE65, which contains the PI2 (show SERPINB1 Proteins) domain, failed to stabilize p53 (show TP53 Proteins), suggesting that the amino-terminal half of the protein plays an important role in the stabilization of p53 (show TP53 Proteins) in osmotically stressed cells.

  10. cell cycle progression by down-regulating thymidylate synthase (show TYMS Proteins) expression

Human Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) interaction partners

  1. Targeted enhancement of the signaling through the Fe65-cortactin (show CTTN Proteins) pathway, by either HDAC6 (show HDAC6 Proteins) inhibition or Tip60 (show KAT5 Proteins) activation, may lead to the development of new therapeutic drugs that are effective for patients with metastatic breast cancers.

  2. Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling.

  3. FE65 influences APP (show APP Proteins) degradation via the proteasome, and phosphorylation of FE65 Ser (show SIGLEC1 Proteins)(610) by SGK1 (show SGK1 Proteins) regulates binding of FE65 to APP (show APP Proteins), APP (show APP Proteins) turnover and processing.

  4. A novel phosphorylation site was identified within Fe65 which mediates gene transcription.

  5. The SV2A (show SV2A Proteins)/FE65 interaction might play a role in synaptic signal transduction.

  6. Data indicate that Fe65 is a positive estrogen receptor alpha (ERalpha (show ESR1 Proteins)) transcriptional regulator.

  7. FE65 interactions with BLM and MCM proteins may contribute to the neuronal cell cycle re-entry observed in brains affected by Alzheimer's disease.

  8. A ternary complex consisting of AICD, FE65, and TIP60 (show KAT5 Proteins) down-regulates Stathmin1.

  9. Both amyloid-beta precursor protein and Fe65 are co-localized in model Hirano bodies associated with Alzheimer's disease.

  10. Fe65 carries out different functions depending on its location in the regulation of Notch1 (show NOTCH1 Proteins) signaling.

Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with APBB1

  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1)
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (apbb1)
  • amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein (APBB1IP)
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Apbb1)
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (Apbb1)
  • apbb1 protein
  • FE65 protein
  • MGC80654 protein
  • MGC:9072 protein
  • RIR protein

Protein level used designations for APBB1

amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) , amyloid beta A4 precursor protein-binding, family B, member 1 , amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein , amyloid beta A4 precursor protein-binding family B member 1-like , amyloid beta A4 precursor protein-binding family B member 1 , adaptor protein FE65a2 , stat-like protein , amyloid beta precursor protein-binding B1

GENE ID SPECIES
100069964 Equus caballus
446838 Xenopus laevis
466415 Pan troglodytes
100030868 Monodelphis domestica
100350673 Oryctolagus cuniculus
100354159 Oryctolagus cuniculus
100401543 Callithrix jacchus
100444276 Pongo abelii
100475168 Ailuropoda melanoleuca
11785 Mus musculus
322 Homo sapiens
29722 Rattus norvegicus
476833 Canis lupus familiaris
505096 Bos taurus
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