FE65 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2714775

Product Details

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This FE65 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human APBB1 / FE65 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Alternative Name: Apbb1,fe65 (APBB1 Products)

Synonyms: FE65 Protein, MGC:9072 Protein, RIR Protein, apbb1 Protein, MGC80654 Protein, Fe65 Protein, Rir Protein, amyloid beta precursor protein binding family B member 1 Protein, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog Protein, amyloid beta (A4) precursor protein-binding, family B, member 1 Protein, APBB1 Protein, apbb1.L Protein, Apbb1 Protein

Background: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer&aposs disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product&aposs nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer&aposs disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 77.1 kDa

NCBI Accession: NP_001155

Pathways: Positive Regulation of Response to DNA Damage Stimulus