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ANAPC5 encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. Additionally we are shipping ANAPC5 Kits (9) and ANAPC5 Proteins (7) and many more products for this protein.
Showing 10 out of 89 products:
Human Polyclonal ANAPC5 Primary Antibody for EIA, WB - ABIN950454
Wäsch, Robbins, Cross: The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression. in Oncogene 2010
Show all 5 references for ABIN950454
Human Polyclonal ANAPC5 Primary Antibody for EIA, WB - ABIN499299
Peters: The anaphase promoting complex/cyclosome: a machine designed to destroy. in Nature reviews. Molecular cell biology 2006
Show all 3 references for ABIN499299
Human Polyclonal ANAPC5 Primary Antibody for FACS, WB - ABIN654927
Turnell, Stewart, Grand, Rookes, Martin, Yamano, Elledge, Gallimore: The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. in Nature 2005
Human Polyclonal ANAPC5 Primary Antibody for ELISA, WB - ABIN1452003
Yu, Peters, King, Page, Hieter, Kirschner: Identification of a cullin homology region in a subunit of the anaphase-promoting complex. in Science (New York, N.Y.) 1998
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 (show ANAPC4 Antibodies) subunits and does not require UL97-mediated phosphorylation of Cdh1 (show CDH1 Antibodies).
Studies indicate that APC (show APC Antibodies)/C(Cdh1 (show CDH1 Antibodies)) is required to maintain genomic stability.
Results show that Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) element of platelet-derived growth factor 2 mRNA.
APC5 and APC7 (show ANAPC7 Antibodies) suppress E1A (show BCKDHA Antibodies)-mediated transformation in a CBP/p300 (show CREBBP Antibodies)-dependent manner, indicating that these components of the APC (show APC Antibodies)/C may be targeted during cellular transformation
The anaphase-promoting complex protein 5 (show CAPS Antibodies) (AnapC5) associates with A20 (show TNFAIP3 Antibodies) and inhibits IL-17 (show IL17A Antibodies)-mediated signal transduction.
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
anaphase-promoting complex subunit 5
, anaphase promoting complex subunit 5
, cyclosome subunit 5
, anaphase-promoting complex subunit 5-like