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ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 Proteins (ARAP1)

The protein encoded by ARAP1 contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. Additionally we are shipping ARAP1 Antibodies (43) and ARAP1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ARAP1 69710 Q4LDD4
ARAP1 116985 Q96P48
Rat ARAP1 ARAP1 361617  
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Top ARAP1 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ARAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1) Interaction Partners

Mouse (Murine) ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1) interaction partners

  1. Increased ARAP (show INS Proteins)1 expression might contribute to type 2 diabetes susceptibility at this Genome-wide association studies locus.

  2. Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.

  3. afadin regulates the cyclical activation and inactivation of Rap1 (show TERF2IP Proteins), Rac1, and RhoA (show RHOA Proteins) through SPA-1 and ARAP1.

Human ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1) interaction partners

  1. Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population.

  2. The proinsulin (show INS Proteins)-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets.

  3. a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1 (show ARF1 Proteins)/5 pathway.

  4. Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.

  5. Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin (show INS Proteins) release.

  6. ARAP1 associated with CIN85 (show SH3KBP1 Proteins) affects epidermal growth factor receptor (show EGFR Proteins) endocytic trafficking

  7. PTK6 (show PTK6 Proteins) enhances EGFR (show EGFR Proteins) signaling by inhibition of EGFR (show EGFR Proteins) down-regulation through phosphorylation of ARAP1 in breast cancer cells.

  8. ARAP1 acts primarily on Arf6 (show ARF6 Proteins) in vivo.

  9. ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death.

  10. ARAP1 controls the late steps of the endocytic trafficking of the EGF-R (show EGFR Proteins)

ARAP1 Protein Profile

Protein Summary

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ARAP1

  • ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (ARAP1)
  • ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (LOC100341403)
  • centaurin, delta 2 (centd2)
  • ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (Arap1)
  • 2410002L19Rik protein
  • ARAP1 protein
  • Centd2 protein
  • Ci-ArfGAP-8 protein
  • mKIAA0782 protein

Protein level used designations for ARAP1

centaurin delta 2 , centaurin, delta 2 , ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 , arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 , centaurin-delta-2 , cnt-d2 , ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1

GENE ID SPECIES
451406 Pan troglodytes
511889 Bos taurus
100014939 Monodelphis domestica
100052506 Equus caballus
100090045 Ornithorhynchus anatinus
100341403 Oryctolagus cuniculus
100511767 Sus scrofa
100594751 Nomascus leucogenys
100169677 Ciona intestinalis
485207 Canis lupus familiaris
69710 Mus musculus
116985 Homo sapiens
361617 Rattus norvegicus
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