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ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. Additionally we are shipping Asporin Kits (40) and Asporin Proteins (4) and many more products for this protein.
Showing 10 out of 46 products:
Human Polyclonal Asporin Primary Antibody for EIA, IF - ABIN374529
Hurng, Kurylo, Marshall, Webb, Ryder, Ho: Discontinuities in the human bone-PDL-cementum complex. in Biomaterials 2011
Show all 3 references for ABIN374529
Human Polyclonal Asporin Primary Antibody for ICC, IF - ABIN250383
Yang, Nyalwidhe, Guo, Drake, Semmes: Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer. in Molecular & cellular proteomics : MCP 2011
Show all 2 references for ABIN250383
Human Polyclonal Asporin Primary Antibody for IF, IHC (p) - ABIN390536
Ikegawa: Expression, regulation and function of asporin, a susceptibility gene in common bone and joint diseases. in Current medicinal chemistry 2008
Chicken Polyclonal Asporin Primary Antibody for IHC, WB - ABIN2775444
Kizawa, Kou, Iida, Sudo, Miyamoto, Fukuda, Mabuchi, Kotani, Kawakami, Yamamoto, Uchida, Nakamura, Notoya, Nakamura, Ikegawa: An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. in Nature genetics 2005
Mapping of the OGN (show OGN Antibodies) and ASPN genes and association with growth and carcass traits.
To test the associations of ASPN variations with risk of subsequent oncologic outcomes.
Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR (show EGFR Antibodies) signaling pathway.
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.
this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA
Osteomodulin (show OMD Antibodies), osteoglycin (show OGN Antibodies), and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
Asporin may represent a new therapeutic target molecule for the development of drugs aimed at manipulating the cancer microenvironment.
This meta-analysis shows that the ASPN D14, D13, and D15 (show MRPL16 Antibodies) alleles are not associated with the development of osteoarthritis in Europeans and Asians. [Meta-Analysis]
A meta-analysis suggest that the D-repeat of asporin gene (ASPN) may not be a major susceptibility locus in the Caucasian and Asian populations with knee osteoarthritis.
polymorphisms within the ASPN gene could influence knee osteoarthritis susceptibility
D14-PLAP-1 (show ALP Antibodies) suppressed BMP-2 (show BMP2 Antibodies) signal transduction more efficiently than D13-PLAP-1 (show ALP Antibodies); stronger affinity of D14-PLAP-1 (show ALP Antibodies) protein to BMP-2 (show BMP2 Antibodies) compared with D13-PLAP-1 (show ALP Antibodies) protein. D repeat polymorphism of PLAP-1/asporin has influence on functions of PDL cells.
inhibition of TLR2 (show TLR2 Antibodies)- and TLR4 (show TLR4 Antibodies)-induced inflammatory responses and binding abilities to TLR2 (show TLR2 Antibodies) and TLR4 (show TLR4 Antibodies)
positively regulates FGF-2 (show FGF2 Antibodies) activity through a direct interaction
Findings suggest that asporin is one of the important cartilage matrix proteins that binds to the ECM (show MMRN1 Antibodies) and TGF-beta1 (show TGFB1 Antibodies) and thereby modulates interactions between TGF-beta (show TGFB1 Antibodies) and its signaling receptors.
PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 (show BMP2 Antibodies) activity to prevent the periodontal ligament from developing non-physiological mineralization
The findings indicate that TGF-beta1 (show TGFB1 Antibodies) induces ASPN through Smad3 (show SMAD3 Antibodies) but that this induction is indirect.
Leucine-rich repeat motif 5 (LRR5) of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 (show BMP2 Antibodies) interaction.
The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
, biglycan-like protein 3
, asporin (LRR class 1)
, asporin proteoglycan
, periodontal ligament associated protein 1
, small leucine-rich protein 1C
, periodontal ligament-associated protein 1