You are viewing an incomplete version of our website. Please click to reload the website as full version.

BCL2-Interacting Killer (Apoptosis-Inducing) Proteins (BIK)

The protein encoded by BIK shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Additionally we are shipping BIK Antibodies (124) and BIK Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BIK 12124  
BIK 638 Q13323
Rat BIK BIK 114496  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top BIK Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

BIK Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) Interaction Partners

Mouse (Murine) BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) interaction partners

  1. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (show SQSTM1 Proteins) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.

  2. Src (show SRC Proteins) tyrosine kinase (show TYRO3 Proteins) inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.

  3. The Bik protein, even in combination with Noxa (show PMAIP1 Proteins), is not a potent suppressor of c-Myc (show MYC Proteins)-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc (show MYC Proteins)-driven tumours.

  4. BIKDD, a constitutively active mutant form of proapoptotic gene, BIK, effectively induces apoptosis of breast cancer cells and synergizes with lapatinib.

  5. Blk has been mapped to chromosome 15 and overexpressed in transitional B cells of A/WySnJ mice, which demonstrate a cell-autonomous defect leading to excessive apoptosis.

  6. any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only (show BBC3 Proteins) proteins

  7. Data show that Bik and Bim (show BCL2L11 Proteins) share the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development.

  8. Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR-VISA (show MAVS Proteins), exhibited antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic mouse models of pancreatic tumors with virtually no toxicity

  9. evaluated the inhibitory effect of BikDD on the growth kinetics of intraperitoneally inoculated CT-26 (show DDX53 Proteins)-Luc

  10. Enhanced expression in Bcl-2 (show BCL2 Proteins) deficient cells leads to cell death with autophagic features.

Human BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) interaction partners

  1. our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM (show CCNA1 Proteins) and favors a more aggressive phenotype, due to the molecular change of different pathways

  2. HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression

  3. BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD.

  4. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (show SQSTM1 Proteins) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.

  5. Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1.

  6. Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase (show MAPK1 Proteins) signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase (show MAPK1 Proteins) signaling.

  7. BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients

  8. Src (show SRC Proteins) tyrosine kinase (show TXK Proteins) inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.

  9. A previously undescribed indirect epigenetic regulation of BIK in FA-C lymphoblasts is mediated by DeltaNp73, an isoform of p73 (show TP73 Proteins) lacking its transactivation domain that activates BIK through a proximal element in its promoter.

  10. Data indicate that methylation-induced transcriptional silencing of the BIK (bcl2-interacting killer) pro-apoptotic gene may occur in multiple myeloma (MM), which might serve as a predictor of the development of relapsed/refractory MM.

BIK Protein Profile

Protein Summary

The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.

Gene names and symbols associated with BIK

  • BCL2-interacting killer (apoptosis-inducing) (BIK)
  • BCL2-interacting killer (BIK)
  • BCL2-interacting killer (Bik)
  • BCL2-interacting killer (apoptosis-inducing) (Bik)
  • BCL2-interacting killer (apoptosis-inducing) (bik)
  • BIK protein
  • Biklk protein
  • BIP1 protein
  • Blk protein
  • BP4 protein
  • NBK protein
  • si:dkey-31f5.6 protein

Protein level used designations for BIK

BCL2-interacting killer (apoptosis-inducing) , BCL2-interacting killer , apoptosis inducer NBK , bcl-2-interacting killer , bik-like killer protein , apoptosis-inducing NBK

GENE ID SPECIES
470232 Pan troglodytes
711479 Macaca mulatta
790946 Felis catus
12124 Mus musculus
638 Homo sapiens
114496 Rattus norvegicus
564030 Danio rerio
Selected quality suppliers for BIK Proteins (BIK)
Did you look for something else?