anti-BCL2-Associated Athanogene 3 (BAG3) Antibodies

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. Additionally we are shipping BAG3 Proteins (19) and BAG3 Kits (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BAG3 9531 O95817
BAG3 29810 Q9JLV1
BAG3 293524  
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Top anti-BAG3 Antibodies at antibodies-online.com

Showing 10 out of 127 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-BAG3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HT1080 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: BAG3 Antibody [NBP2-15543] - Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using antibody at 1:100 dilution. Western Blot: BAG3 Antibody [NBP2-15543] - BAG3 antibody detects BAG3 protein by Western blot analysis. A. 50 ug mouse heart lysate/extract 7. 5 % SDS-PAGEBAG3 antibody dilution: 1:1000. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- Bag3 Picoband antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Bag3 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti-Bag3 antibody, Western blotting Lane 1: MCF-7 Cell Lysate Lane 2: JURKAT Cell Lysate Lane 3: A549 Cell Lysate Lane 4: HELA Cell Lysate Lane 5: COLO320 Cell Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Goat Un-conjugated ELISA, WB Antibody (0.1µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (fro), IHC (p), IP, SimWes, WB Simple Western: BAG3 Antibody [NBP2-27398] - Simple Western lane view shows a specific band for BAG3 in 0.5 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Immunohistochemistry-Frozen: BAG3 Antibody [NBP2-27398] - Frozen mouse muscle tissue section stained for BAG-3 expression using NBP2-27398 at 1:2000. The tissue section was fixed in 3.8% paraformaldehyde prior to staining. BAG-3 localizes with Z-disk proteins. 0.05 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated ISt, IHC (p), WB WB Image BAG3 antibody detects BAG3 protein by Western blot analysis. A. 30 µg K562 whole cell lysate/extract 7.5 % SDS-PAGE BAG3 antibody , dilution: 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using BAG3, antibody at 1:100 dilution. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$451.00
Details

BAG3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-BAG3 Antibodies

  1. Human Polyclonal BAG3 Primary Antibody for ICC, IF - ABIN4282959 : Goldman, Chen, Roesly, Hill, Tome, Dvorak, Bernstein, Dvorak: Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis. in American journal of physiology. Gastrointestinal and liver physiology 2011 (PubMed)
    Show all 4 references for 4282959

  2. Human Polyclonal BAG3 Primary Antibody for IHC, ELISA - ABIN1452054 : Lee, Takahashi, Yasuhara, Inazawa, Kamada, Tsujimoto: Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. in Oncogene 2000 (PubMed)
    Show all 2 references for 1452054

  3. Cow (Bovine) Polyclonal BAG3 Primary Antibody for WB - ABIN2783302 : Franceschelli, Rosati, Lerose, De Nicola, Turco, Pascale: Bag3 gene expression is regulated by heat shock factor 1. in Journal of cellular physiology 2008 (PubMed)

  4. Human Polyclonal BAG3 Primary Antibody for ELISA, WB - ABIN184770 : Doong, Price, Kim, Gasbarre, Probst, Liotta, Blanchette, Rizzo, Kohn: CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. in Oncogene 2000 (PubMed)

  5. Human Polyclonal BAG3 Primary Antibody for IHC, IHC (p) - ABIN4282955 : Nymoen, Hetland Falkenthal, Holth, Ow, Ivshina, Tropé, Kuznetsov, Staff, Davidson: Expression and clinical role of chemoresponse-associated genes in ovarian serous carcinoma. in Gynecologic oncology 2015 (PubMed)

More Antibodies against BAG3 Interaction Partners

Zebrafish BCL2-Associated Athanogene 3 (BAG3) interaction partners

  1. This study therefore identifies both BAG3 reduction and autophagy promotion as potential therapies for FLNC (show FLNC Antibodies)(W2710X) myofibrillar myopathy, and identifies protein insufficiency due to sequestration, compounded by impaired autophagy, as the cause.

  2. findings showed that the P209L mutation causes BAG3 to aggregate; proposed that the gradual loss of available BAG3(wt) and BAG3(P209L) proteins results in insufficiency leading to myofibrillar disintegration

Human BCL2-Associated Athanogene 3 (BAG3) interaction partners

  1. The spatial regulation of mTORC1 exerted by BAG3 apparently provides the basis for a simultaneous induction of autophagy and protein synthesis to maintain the proteome under mechanical strain.

  2. This study therefore identifies both BAG3 reduction and autophagy promotion as potential therapies for FLNC (show FLNC Antibodies)(W2710X) myofibrillar myopathy, and identifies protein insufficiency due to sequestration, compounded by impaired autophagy, as the cause.

  3. variants in TNNT2 (show TNNT2 Antibodies) and BAG3 are associated with a high propensity to life-threatening cardiomyopathy presenting from childhood and young adulthood.

  4. It has been demonstrated that HSPB8 (show HSPB8 Antibodies)-BAG3-HSP70 (show HSP70 Antibodies) ensures the functionality of stress granules and restores proteostasis by targeting defective ribosomal products for degradation.

  5. The authors propose that the chaperone-mediated autophagy function of BAG3 represents a specific host defense strategy to counteract the function of VP40 in promoting efficient egress and spread of virus particles.

  6. BAG3 bound to Hsp70 (show HSP70 Antibodies) at the same time as Hsp22 (show HSPB8 Antibodies), Hsp27 (show HSPB1 Antibodies), or alphaB-crystallin (show CRYAB Antibodies), suggesting that it might physically bring the chaperone families together into a complex.

  7. These results suggest that Bag1 (show BAG1 Antibodies) and Bag3 control the stability of the Hsc70 (show HSPA8 Antibodies)-client complex using at least two distinct protein-protein contacts, providing a previously under-appreciated layer of molecular regulation in the human Hsc70 (show HSPA8 Antibodies) system.

  8. we report the first mammalian model of a single amino acid mutation of BAG3 (P209L) in exon 3 of Bag3 associated with the development of muscle disease with left ventricular dysfunction and heart failure

  9. High BAG3 expression Correlates with Sebaceous Gland Carcinoma of the Eyelid.

  10. These results indicate a possible role for BAG3 protein in the maintenance of cell survival in endometrioid endometrial cancer.

Mouse (Murine) BCL2-Associated Athanogene 3 (BAG3) interaction partners

  1. The spatial regulation of mTORC1 exerted by BAG3 apparently provides the basis for a simultaneous induction of autophagy and protein synthesis to maintain the proteome under mechanical strain.

  2. Genetic variation in BAG3 plays an important role in the prevention of ischemic tissue necrosis.

  3. The aim of this study was to investigate the possible hemodynamic effects of BAG3 performing both in vitro and in vivo experiments.

  4. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2 (show CA2 Antibodies)+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure.

  5. molecular association of MyHC (show MYH13 Antibodies) and BIS is necessary for MyHC (show MYH13 Antibodies) stabilization in skeletal muscle.

  6. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

  7. Bis is upregulated in astrocytes after hypoxia-ischemia; hypoxia-ischemia induces progressive cell death in the hippocampi of bis-positive mice, while hippocampal neurons are less vulnerable to hypoxia-ischemia in mice that lack Bis.

  8. Deletion of the bis gene results in a marked increase in the production of corticosterone that is associated with thymic atrophy.

  9. BAG3 and Hsc70 (show HSPA8 Antibodies) interact with actin capping protein (show TMOD4 Antibodies) CapZ (show CAPZA1 Antibodies) to maintain myofibrillar integrity under mechanical stress.

  10. Results indicate that Bis functions to mediate cellular regulation of the stem cell niche on the vascular compartment.

BAG3 Antigen Profile

Protein Summary

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Gene names and symbols associated with BAG3

  • BCL2-associated athanogene 3 (bag3-A) antibody
  • BCL2-associated athanogene 3 (bag3) antibody
  • BCL2-associated athanogene 3 (BAG3) antibody
  • BCL2-associated athanogene 3 (LOC100228262) antibody
  • BCL-2-associated athanogene 3 (BAG3) antibody
  • BCL2-associated athanogene 3 (Bag3) antibody
  • Bcl2-associated athanogene 3 (Bag3) antibody
  • BCL2-associated athanogene 3 (LOC100358030) antibody
  • AA407278 antibody
  • ATBAG3 antibody
  • BAG-3 antibody
  • BAG3 antibody
  • bag3-A antibody
  • BCL-2-associated athanogene 3 antibody
  • Bis antibody
  • CAIR-1 antibody
  • MFM6 antibody
  • mg638 antibody
  • MGC53113 antibody
  • T28J14.160 antibody
  • T28J14_160 antibody
  • zgc:100859 antibody

Protein level used designations for BAG3

BCL2-associated athanogene 3 , BAG family molecular chaperone regulator 3 , BAG family molecular chaperone regulator 3-like , BCL2-binding athanogene 3 , bcl-2-binding protein Bis , docking protein CAIR-1 , BAG-3 , Bcl-2-binding protein Bis , Bcl-2-interacting death suppressor , bcl-2-associated athanogene 3

GENE ID SPECIES
379174 Xenopus laevis
445139 Danio rerio
450778 Pan troglodytes
714420 Macaca mulatta
100145358 Xenopus (Silurana) tropicalis
100228262 Taeniopygia guttata
100481230 Ailuropoda melanoleuca
830613 Arabidopsis thaliana
9531 Homo sapiens
29810 Mus musculus
293524 Rattus norvegicus
486916 Canis lupus familiaris
782633 Bos taurus
423931 Gallus gallus
100156989 Sus scrofa
100358030 Oryctolagus cuniculus
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