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BMP and Activin Membrane-Bound Inhibitor Homolog Proteins (BAMBI)

BAMBI encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. Additionally we are shipping BAMBI Antibodies (44) and BAMBI Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BAMBI 25805 Q13145
BAMBI 68010 Q9D0L6
Rat BAMBI BAMBI 83837 Q91XN4
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Top BAMBI Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

BAMBI Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) , ,
, ,

Top referenced BAMBI Proteins

  1. Human BAMBI Protein expressed in Human Cells - ABIN2003557 : Onichtchouk, Chen, Dosch, Gawantka, Delius, Massagué, Niehrs: Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. in Nature 1999 (PubMed)
    Show all 2 references for ABIN2003557

  2. Mouse (Murine) BAMBI Protein expressed in Human Cells - ABIN2008387 : Sekiya, Adachi, Kohu, Yamada, Higuchi, Furukawa, Nakamura, Nakamura, Tashiro, Kuhara, Ohwada, Akiyama: Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. in The Journal of biological chemistry 2004 (PubMed)

More Proteins for BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI) Interaction Partners

Pig (Porcine) BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI) interaction partners

  1. results indicated that BMP and activin membrane-bound inhibitor homolog(BAMBI) is an FSH (show BRD2 Proteins)-repressed gene in porcine luteinizing granulosa cells and it may be involved in the regulation of ovarian follicle development and oocyte maturation

Zebrafish BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI) interaction partners

  1. This study shows that upregulation of bigh3 and bambia mRNA correlated with the process of fin regeneration and regulation of TGF-b signaling, suggesting a new role for these proteins.

Human BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI) interaction partners

  1. TGFbeta (show TGFB1 Proteins) target genes including TGFBI (show TGFBI Proteins), BAMBI, COL3A1 (show COL3A1 Proteins) and SERPINE1 (show SERPINE1 Proteins) are significantly increased in Diamond Blackfan Anemia induced pluripotent stem cells

  2. The observations illuminated that BAMBI inhibits adipogenesis by a feedback loop (BAMBI-->beta-catenin (show CTNNB1 Proteins) nuclear translocation-->BAMBI), which forms with Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  3. betacatenin expression was downregulated as a result of knocking down of BAMBI, and TGF-beta (show TGFB1 Proteins) was downregulated in a similar manner.

  4. BAMBI alone or in combination with Smad7 (show SMAD7 Proteins) was significantly associated with the OS and DFS (show FST Proteins). These findings suggest that BAMBI and Smad7 (show SMAD7 Proteins) may cooperatively inhibit the TGF-beta (show TGFB1 Proteins) signaling, and thus promote the progression of gastric cancer.

  5. study demonstrates that LPS (show IRF6 Proteins)- and TNF-alpha (show TNF Proteins)-induced NF-kappaBp50-HDAC1 (show HDAC1 Proteins) interaction represses BAMBI transcriptional activity, which contributes to TLR4 (show TLR4 Proteins)-mediated enhancement of TGF-beta (show TGFB1 Proteins) signaling in hepatic stellate cells during liver fibrosis.

  6. Overexpression of BAMBI is associated with the growth and invasion of human osteosarcoma.

  7. Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling

  8. Alterations in BAMBI may play a role in the (patho)physiology of obesity, and manipulation of BAMBI may present a novel therapeutic approach to improve adipose tissue function.

  9. Data show that hepatoprotective effects of adiponectin (show ADIPOQ Proteins) include induction of BAMBI which is reduced in human fatty liver.

  10. BAMBI protein is expressed in endothelial cells and is regulated by autophagy and lysosomal degradation.

Mouse (Murine) BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI) interaction partners

  1. BAMBI is required for normal C2C12 differentiation, and that its role in myogenesis is mediated by the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  2. BAMBI modulates the effects of diabetes on glomerular permselectivity in association with altered ERK1/2 and Smad1 (show SMAD1 Proteins)/5 signaling.

  3. these results provide strong evidence for an important role of endothelium rather than platelet BAMBI as a positive regulator of both thrombus formation and stability.

  4. we provide in vitro and in vivo evidence that BAMBI contributes to endothelial and vascular homeostasis

  5. suggest that BAMBI is involved in negative feedback loops that restrain the TGF-beta (show TGFB1 Proteins) remodeling signals to protect the pressure-overloaded myocardium from uncontrolled extracellular matrix deposition in humans and mice

  6. BAMBI protein is expressed in endothelial cells and is regulated by autophagy and lysosomal degradation.

  7. Transcript levels of TGF-betas and their intracellular effectors correlated directly with genes encoding opioid peptides, whereas BAMBI correlated inversely.

  8. Overexpression of Nma/BAMBI in mouse odontoblast-like cell line MD10-A2 down-regulated expression of DSPP (show DSPP Proteins) by 66% and up-regulated expression of DMP1 (show DMP1 Proteins) four-fold.

  9. and has implications in tumor progression. Genomic organization of the mouse Nma/BAMBI gene and confirmed the chromosomal mapping to human chromosome 10 and mouse chromosome 2.

BAMBI Protein Profile

Protein Summary

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.

Gene names and symbols associated with BAMBI

  • BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) (BAMBI)
  • BMP and activin membrane-bound inhibitor (bambi)
  • BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a (bambia)
  • BMP and activin membrane-bound inhibitor homolog (LOC724378)
  • BMP and activin membrane-bound inhibitor homolog (bambi)
  • BMP and activin membrane-bound inhibitor homolog (LOC100482525)
  • BMP and activin membrane-bound inhibitor homolog (LOC100540171)
  • BMP and activin membrane-bound inhibitor homolog (LOC100553667)
  • BMP and activin membrane-bound inhibitor homolog (LOC100554299)
  • BMP and activin membrane-bound inhibitor homolog (LOC100606459)
  • BMP and activin membrane-bound inhibitor homolog (LOC100647353)
  • BMP and activin membrane-bound inhibitor (BAMBI)
  • BMP and activin membrane-bound inhibitor (Bambi)
  • 2610003H06Rik protein
  • bambi protein
  • cb998 protein
  • fc44c12 protein
  • id:ibd5020 protein
  • nma protein
  • wu:fc44c12 protein
  • wu:fe01e03 protein
  • Zfnma protein

Protein level used designations for BAMBI

BMP and activin membrane-bound inhibitor homolog , BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) , etID64300.12 , non-metastatic gene A protein , putative transmembrane protein NMA , BMP and activin membrane-bound inhibitor, homolog , kinase-deficient TGFbeta superfamily receptor subunit

GENE ID SPECIES
428413 Gallus gallus
449001 Sus scrofa
493556 Xenopus (Silurana) tropicalis
710152 Macaca mulatta
745034 Pan troglodytes
83496 Danio rerio
724378 Apis mellifera
100302750 Saccoglossus kowalevskii
100482525 Ailuropoda melanoleuca
100540171 Meleagris gallopavo
100553667 Anolis carolinensis
100554299 Anolis carolinensis
100606459 Nomascus leucogenys
100647353 Bombus terrestris
25805 Homo sapiens
68010 Mus musculus
83837 Rattus norvegicus
443242 Ovis aries
487081 Canis lupus familiaris
530147 Bos taurus
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