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BAMBI encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. Additionally we are shipping BAMBI Antibodies (44) and BAMBI Kits (8) and many more products for this protein.
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Human BAMBI Protein expressed in Human Cells - ABIN2003557
Onichtchouk, Chen, Dosch, Gawantka, Delius, Massagué, Niehrs: Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. in Nature 1999
Show all 2 references for ABIN2003557
Mouse (Murine) BAMBI Protein expressed in Human Cells - ABIN2008387
Sekiya, Adachi, Kohu, Yamada, Higuchi, Furukawa, Nakamura, Nakamura, Tashiro, Kuhara, Ohwada, Akiyama: Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. in The Journal of biological chemistry 2004
results indicated that BMP and activin membrane-bound inhibitor homolog(BAMBI) is an FSH (show BRD2 Proteins)-repressed gene in porcine luteinizing granulosa cells and it may be involved in the regulation of ovarian follicle development and oocyte maturation
This study shows that upregulation of bigh3 and bambia mRNA correlated with the process of fin regeneration and regulation of TGF-b signaling, suggesting a new role for these proteins.
TGFbeta (show TGFB1 Proteins) target genes including TGFBI (show TGFBI Proteins), BAMBI, COL3A1 (show COL3A1 Proteins) and SERPINE1 (show SERPINE1 Proteins) are significantly increased in Diamond Blackfan Anemia induced pluripotent stem cells
The observations illuminated that BAMBI inhibits adipogenesis by a feedback loop (BAMBI-->beta-catenin (show CTNNB1 Proteins) nuclear translocation-->BAMBI), which forms with Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
betacatenin expression was downregulated as a result of knocking down of BAMBI, and TGF-beta (show TGFB1 Proteins) was downregulated in a similar manner.
BAMBI alone or in combination with Smad7 (show SMAD7 Proteins) was significantly associated with the OS and DFS (show FST Proteins). These findings suggest that BAMBI and Smad7 (show SMAD7 Proteins) may cooperatively inhibit the TGF-beta (show TGFB1 Proteins) signaling, and thus promote the progression of gastric cancer.
study demonstrates that LPS (show IRF6 Proteins)- and TNF-alpha (show TNF Proteins)-induced NF-kappaBp50-HDAC1 (show HDAC1 Proteins) interaction represses BAMBI transcriptional activity, which contributes to TLR4 (show TLR4 Proteins)-mediated enhancement of TGF-beta (show TGFB1 Proteins) signaling in hepatic stellate cells during liver fibrosis.
Overexpression of BAMBI is associated with the growth and invasion of human osteosarcoma.
Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling
Alterations in BAMBI may play a role in the (patho)physiology of obesity, and manipulation of BAMBI may present a novel therapeutic approach to improve adipose tissue function.
Data show that hepatoprotective effects of adiponectin (show ADIPOQ Proteins) include induction of BAMBI which is reduced in human fatty liver.
BAMBI protein is expressed in endothelial cells and is regulated by autophagy and lysosomal degradation.
BAMBI is required for normal C2C12 differentiation, and that its role in myogenesis is mediated by the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
BAMBI modulates the effects of diabetes on glomerular permselectivity in association with altered ERK1/2 and Smad1 (show SMAD1 Proteins)/5 signaling.
these results provide strong evidence for an important role of endothelium rather than platelet BAMBI as a positive regulator of both thrombus formation and stability.
we provide in vitro and in vivo evidence that BAMBI contributes to endothelial and vascular homeostasis
suggest that BAMBI is involved in negative feedback loops that restrain the TGF-beta (show TGFB1 Proteins) remodeling signals to protect the pressure-overloaded myocardium from uncontrolled extracellular matrix deposition in humans and mice
Transcript levels of TGF-betas and their intracellular effectors correlated directly with genes encoding opioid peptides, whereas BAMBI correlated inversely.
Overexpression of Nma/BAMBI in mouse odontoblast-like cell line MD10-A2 down-regulated expression of DSPP (show DSPP Proteins) by 66% and up-regulated expression of DMP1 (show DMP1 Proteins) four-fold.
and has implications in tumor progression. Genomic organization of the mouse Nma/BAMBI gene and confirmed the chromosomal mapping to human chromosome 10 and mouse chromosome 2.
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.
BMP and activin membrane-bound inhibitor homolog
, BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
, non-metastatic gene A protein
, putative transmembrane protein NMA
, BMP and activin membrane-bound inhibitor, homolog
, kinase-deficient TGFbeta superfamily receptor subunit