BAMBI Protein (His tag)

Catalog No. ABIN7317731

Product Details

Target: BAMBI (BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This BAMBI protein is labelled with His tag.

Purpose: Recombinant Human BAMBI Protein (His Tag)

Sequence: Met 1-Ala 152

Characteristics: A DNA sequence encoding the human BAMBI extracellular domain (NP_036474.1) (Met 1-Ala 152) was expressed, fused with a C-terminal polyhistidine tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: BAMBI (BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI))

Alternative Name: BAMBI (BAMBI Products)

Synonyms: NMA Protein, bambi Protein, nma Protein, BAMBI Protein, Zfnma Protein, cb998 Protein, fc44c12 Protein, id:ibd5020 Protein, wu:fc44c12 Protein, wu:fe01e03 Protein, 2610003H06Rik Protein, bambi-A Protein, zgc:91871 Protein, BMP and activin membrane bound inhibitor Protein, BMP and activin membrane-bound inhibitor homolog Protein, BMP and activin membrane-bound inhibitor Protein, BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a Protein, BMP and activin membrane-bound inhibitor L homeolog Protein, BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b Protein, BAMBI Protein, bambi Protein, bambia Protein, Bambi Protein, LOC724378 Protein, LOC100647353 Protein, bambi.L Protein, bambib Protein

Background:

Background: BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.

Synonym: NMA

Molecular Weight: 16.1 kDa

NCBI Accession: NP_036474