Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). Additionally we are shipping BAP1 Proteins (7) and BAP1 Kits (4) and many more products for this protein.
Showing 10 out of 124 products:
Human Monoclonal BAP1 Primary Antibody for IF, WB - ABIN1105494
Jensen, Proctor, Marquis, Gardner, Ha, Chodosh, Ishov, Tommerup, Vissing, Sekido, Minna, Borodovsky, Schultz, Wilkinson, Maul, Barlev, Berger, Prendergast, Rauscher: BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. in Oncogene 1998
Human Polyclonal BAP1 Primary Antibody for IHC (p), WB - ABIN388948
Abdel-Rahman, Pilarski, Cebulla, Massengill, Christopher, Boru, Hovland, Davidorf: Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. in Journal of medical genetics 2011
Human Monoclonal BAP1 Primary Antibody for FACS, WB - ABIN258775
Harbour, Onken, Roberson, Duan, Cao, Worley, Council, Matatall, Helms, Bowcock: Frequent mutation of BAP1 in metastasizing uveal melanomas. in Science (New York, N.Y.) 2010
the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.
Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.
INO80 (show INO80 Antibodies) is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
Both Vhl (show VHL Antibodies) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (show VHL Antibodies) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (show VHL Antibodies) in the kidney.
Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.
Cx32 (show GJB1 Antibodies) expression is in part related to induction of tight junctions through modulation of Magi1 (show CNKSR3 Antibodies) expression in an immortalized hepatic cell line.
ARIP1 (show MAGI2 Antibodies) and ARIP2 (show SYNJ2BP Antibodies) are co-expressed in some nerve cells and their biological activities are distinct.
results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (show HCFC1 Antibodies) and OGT (show OGT Antibodies) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm
Data conclude that the up-regulation of sdk-1 (show SDK1 Antibodies) in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 (show CNKSR3 Antibodies) function.
Our study revealed a unique tissue-specific significance of BAP1 (show RNF2 Antibodies) mutation in prognostic prediction among different types of cancer. Clinically, combining detection of BAP1 (show RNF2 Antibodies) mutation and other driver mutations may further allow for a more precise molecular taxonomy to stratify patients into distinct subgroups in uveal melanoma and clear cell renal cell carcinoma (show MOK Antibodies)
on the basis of our meta-analysis, we have demonstrated a peculiar role of BAP1 (show RNF2 Antibodies) in influencing the prognosis in cancer. Thus, BAP1 (show RNF2 Antibodies) could be considered as an important potential target for personalized medicine.
Patients with uveal melanoma can be classified into 3 groups, of which EIF1AX (show EIF1AX Antibodies)-mutated tumors and tumors without BAP1 (show RNF2 Antibodies), SF3B1 (show SF3B2 Antibodies), or EIF1AX (show EIF1AX Antibodies) mutations are associated with prolonged survival and low metastatic risk, SF3B1 (show SF3B2 Antibodies)-mutated tumors are associated with late metastasis
The frequency of BAP1 (show RNF2 Antibodies) germline pathogenic variants in consecutive Finnish patients with uveal melanoma who come from a high-risk region for the development of this cancer is comparable with reports from other populations.
BAP1 (show RNF2 Antibodies), SF3B1 (show SF3B2 Antibodies), and EIF1AX (show EIF1AX Antibodies) mutations occur during uveal melanoma tumor progression in an almost mutually exclusive manner and are associated with different levels of metastatic risk.
Our cohort included 257 lung cancer patients, of which 155 (60%) were adenocarcinomas and 72 (28%) were squamous cell carcinomas, with no other subtype comprising more than 3%. BAP1 (show RNF2 Antibodies) loss of expression was found in only one lung cancer. We conclude that BAP1 (show RNF2 Antibodies) mutation occurs very infrequently (0.4%) in non-small cell lung cancer.
expression of BAP1 (show RNF2 Antibodies) is downregulated in gastric adenocarcinoma and its decreased expression is associated with more advanced tumor progressions (advanced T category, M category, and TNM (show ODZ1 Antibodies) stage) and malignant phenotypes (histologic grade). Additionally, low BAP1 (show RNF2 Antibodies) expression is correlated to poor prognosis in gastric adenocarcinoma.
FISH analysis of the p16/CDKN2A (show CDKN2A Antibodies) status and BAP1 (show RNF2 Antibodies) immunohistochemistry in the spindled mesothelium provide a more objective means to differentiate between biphasic mesothelioma and epithelioid mesothelioma with atypical stromal cells
BAP1 (show RNF2 Antibodies) mutation is associated with melanocytic tumors of the central nervous system.
Data showed that patients with biallelic BAP1 (show RNF2 Antibodies) mutation had the worse recurrence-free survival.
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.
BRCA1-associated protein 1
, ubiquitin C-terminal hydrolase X4
, ubiquitin carboxyl-terminal hydrolase BAP1
, cerebral protein 6
, cerebral protein-13
, Brca1 associated protein 1
, BAI1-associated protein 3
, ubiquitin carboxy-terminal hydrolase
, BAI1-associated protein 1
, guanylate kinase membrane-associated inverted 1
, membrane-associated guanylate kinase inverted 1
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1