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The protein encoded by BTG3 is a member of the BTG/Tob family. Additionally we are shipping BTG3 Antibodies (39) and BTG3 Kits (12) and many more products for this protein.
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Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
Results suggest that ANA is a suppressor of ectopic bone formation induced by bone morphogenetic proteins, and this inhibitory ANA activity is a part of the negative feedback regulation of BMP function.
BTG3 overexpression might reverse the aggressive phenotypes and be employed as a potential target for gene therapy of gastric cancer.
The suppressed migration and invasion abilities found in BTG3-overexpressing esophageal adenocarcinoma cells. Our findings suggested that BTG3 is suppressor in the progression of esophageal adenocarcinoma
BTG3 binds and suppresses AKT (show AKT1 Proteins), a kinase frequently deregulated in cancers.
Down-regulation of BTG3 promotes cell proliferation, migration and invasion in gastric cancer.
BTG3 protein expression may be considered as a good marker to indicate the favorable prognosis of epithelial ovarian carcinoma.
These results disclosed an important role of BTG3 in lung tumorigenesis.
BTG3-dependent CHK1 (show CHEK1 Proteins) ubiquitination contributes to its chromatin localization and activation and a defect in this regulation may increase genome instability and promote tumorigenesis
loss of BTG3 in normal cells induced cellular senescence, which was correlated with enhanced ERK-AP1 signaling and elevated expression of the histone H3K27me3 demethylase JMJD3/KDM6B
by disrupting the DNA binding activity of E2F1 (show E2F1 Proteins), BTG3 participates in the regulation of E2F1 (show E2F1 Proteins) target gene expression. Therefore, our studies have revealed a previously unidentified pathway through which the activity of E2F1 (show E2F1 Proteins) may be guarded by activated p53 (show TP53 Proteins).
These data support the hypothesis that BTG3 may act to suppress tumorigenesis and that hypermethylation is an important mechanism for inactivation of BTG3 and perhaps other tumor suppressor genes.
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
B cell translocation protein 3
, protein BTG3
, B-cell translocation gene 3
, BTG family member 3
, abundant in neuroepithelium area protein
, protein Tob5