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anti-Baculoviral IAP Repeat-Containing 6 (BIRC6) Antibodies

BIRC6 encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. Additionally we are shipping Baculoviral IAP Repeat-Containing 6 Kits (5) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BIRC6 57448 Q9NR09
BIRC6 12211 O88738
BIRC6 313876  
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Top anti-Baculoviral IAP Repeat-Containing 6 Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p) Immunohistochemistry of BRUCE in human small intestine tissue with BIR... 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Dog Mouse Un-conjugated IF, WB Western blot analysis of BRUCE on a SW-13 cell lysate (Human adrenal g... Immunofluorescence staining of HeLa cells (Human cervical epitheloid c... 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Goat Un-conjugated IHC (p), ELISA 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC (p) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded human esophageal carcinoma labele... 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry of BRUCE in human small intestine tissue with BRU... 0.1 mg Log in to see 2 to 3 Days
$330.00
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

BIRC6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-Baculoviral IAP Repeat-Containing 6 Antibodies

  1. Human Polyclonal BIRC6 Primary Antibody for EIA, IHC (p) - ABIN1450019 : Schimmer: Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. in Cancer research 2004 (PubMed)

  2. Human Polyclonal BIRC6 Primary Antibody for ELISA, WB - ABIN184895 : Chen, Naito, Hori, Mashima, Yamori, Tsuruo: A human IAP-family gene, apollon, expressed in human brain cancer cells. in Biochemical and biophysical research communications 1999 (PubMed)

  3. Dog (Canine) Monoclonal BIRC6 Primary Antibody for IF, WB - ABIN968408 : Hauser, Bardroff, Pyrowolakis, Jentsch: A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. in The Journal of cell biology 1998 (PubMed)

More Antibodies against Baculoviral IAP Repeat-Containing 6 Interaction Partners

Human Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

  1. Results show that in addition to the scaffolding function in complex formation, BRUCE has an E3 ligase function to promote BRIT1 (show MCPH1 Antibodies) deubiquitination by USP8 (show USP8 Antibodies) leading to accumulation of BRIT1 (show MCPH1 Antibodies) at DNA double-strand break.

  2. BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and could be a potential target for colorectal cancer therapy.

  3. The study demonstrates that the T allele of the rs2754511 in the BIRC6 gene plays a protective role in pseudoexfoliative glaucoma patients of the Pakistani population.

  4. Humanin signaling pathway via htHNR/JAKs/STAT3 (show STAT3 Antibodies) increased the expression levels of mRNA and protein of Apollon/Bruce, an unusual member of the inhibitors of apoptosis proteins

  5. BRUCE acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8 (show USP8 Antibodies)) and BRIT1 (show MCPH1 Antibodies) in a complex to coordinate USP8 (show USP8 Antibodies)-catalyzed deubiquitination of BRIT1 (show MCPH1 Antibodies).

  6. findings demonstrate that BIRC6 overexpression in hepatocellular carcinoma specimens is indicative of poor prognosis and that its interaction with p53 (show TP53 Antibodies) facilitates the degradation of p53 (show TP53 Antibodies)

  7. The expression of BIRC6 in the cytoplasm is associated with epithelial ovarian cancer (EOC) differentiation and may be a novel predictor for poor prognosis of EOC patients after curative resection.

  8. APPOLON to be a novel regulator of mitotic CYCLIN A (show CCNA2 Antibodies) degradation independent of SAC (show ADCY10 Antibodies).

  9. Elevated expression of BIRC6 protein in non-small-cell lung cancers is associated with cancer recurrence and chemoresistance.

  10. Knockdown experiments were performed using BIRC6 lentiviral shRNA and phenotype responses were analyzed by Western blot and MTT-assays.Upon silencing of BIRC6 by shRNA, DIABLO protein levels increased and cells went into apoptosis.

Cow (Bovine) Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

  1. The results of this study reveal the importance of BIRC6 expression for embryo survival during bovine preimplantation embryo development.

Mouse (Murine) Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

  1. Humanin signaling pathway via htHNR/JAKs/STAT3 (show STAT3 Antibodies) increased the expression levels of mRNA and protein of Apollon/Bruce, an unusual member of the inhibitors of apoptosis proteins

  2. BRUCE acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8 (show USP8 Antibodies)) and BRIT1 (show MCPH1 Antibodies) in a complex to coordinate USP8 (show USP8 Antibodies)-catalyzed deubiquitination of BRIT1 (show MCPH1 Antibodies).

  3. BRUCE protects cells against apoptosis and functions as an inhibitor of apoptosis.

  4. BRUCE is broadly expressed in embryonic, extraembryonic, and adult mouse tissues, this bifunctional protein might play a unique role in normal trophoblast differentiation and embryonic survival

  5. p53 (show TP53 Antibodies) is a downstream effector of Bruce, and, in response to loss of Bruce function, p53 (show TP53 Antibodies) activates Pidd (show PIDD Antibodies)/caspase-2 (show CASP2 Antibodies) and Bax (show BAX Antibodies)/Bak (show BAK1 Antibodies), leading to mitochondrial apoptosis

  6. Birc6 plays a role in cell division

  7. These results establish a previously unrecognized link between NFAT (show NFATC1 Antibodies) signaling and regulation of IAP (show ALPI Antibodies) expression and are the first to identify a signaling pathway that increases BRUCE expression.

Baculoviral IAP Repeat-Containing 6 (BIRC6) Antigen Profile

Protein Summary

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.

Gene names and symbols associated with BIRC6

  • baculoviral IAP repeat containing 6 (BIRC6) antibody
  • baculoviral IAP repeat-containing 6 (BIRC6) antibody
  • baculoviral IAP repeat-containing 6 (birc6) antibody
  • baculoviral IAP repeat containing 6 (birc6) antibody
  • baculoviral IAP repeat-containing 6 (Birc6) antibody
  • A430032G04Rik antibody
  • A430040A19Rik antibody
  • AA501170 antibody
  • APOLLON antibody
  • BIRC6 antibody
  • Bruce antibody
  • D630005A10Rik antibody
  • mKIAA1289 antibody

Protein level used designations for BIRC6

baculoviral IAP repeat-containing 6 (apollon) , baculoviral IAP repeat-containing 6 , BIR repeat-containing ubiquitin-conjugating enzyme , baculoviral IAP repeat-containing protein 6 , ubiquitin-conjugating BIR domain enzyme apollon , ubiquitin-conjugating BIR-domain enzyme apollon , apollon , baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme , baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6

GENE ID SPECIES
421463 Gallus gallus
475718 Canis lupus familiaris
709443 Macaca mulatta
720431 Macaca mulatta
796547 Danio rerio
100027051 Monodelphis domestica
100070568 Equus caballus
100079899 Ornithorhynchus anatinus
100135722 Xenopus (Silurana) tropicalis
100225419 Taeniopygia guttata
100342432 Oryctolagus cuniculus
100448259 Pongo abelii
100484115 Ailuropoda melanoleuca
57448 Homo sapiens
534211 Bos taurus
12211 Mus musculus
313876 Rattus norvegicus
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