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BTF3 encodes the basic transcription factor 3. Additionally we are shipping BTF3 Antibodies (78) and BTF3 Proteins (11) and many more products for this protein.
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BTF3, HINT1 (show HINT1 ELISA Kits), NDRG1 (show NDRG1 ELISA Kits) and ODC1 (show ODC1 ELISA Kits) protein over-expression in human prostate cancer tissue
BTF3 expression is associated with enhanced cell proliferation, reduced cell cycle regulation and apoptosis and its silencing decreased colony forming and proliferation of gastric cancer cells.
BTF3 overexpression may be an early event in colorectal cancer development and could be useful biomarker for the early stage of colorectal cancers (CRC (show CALR ELISA Kits)); BTF3 has positive correlations with NF-kappaB (show NFKB1 ELISA Kits), RAD50 (show RAD50 ELISA Kits), MRE11 (show MRE11A ELISA Kits), NBS1 (show NBN ELISA Kits) and AEG-1 (show MTDH ELISA Kits) and might influence complex signal pathways in CRC (show CALR ELISA Kits)
BTF3 is overexpressed in pancreatic ductal adenocarcinoma , where it acts as a transcriptional regulator rather than a direct modulator of apoptosis.
BTF3 interacts with ERalpha (show ESR1 ELISA Kits) that has been activated either by 17beta-estradiol (ligand-dependent activation) or by epidermal growth factor (show EGF ELISA Kits) (ligand-independent activation).
In addition to RNA polymerase II (otherwise RNA pol II, RNA polymerase B), four general transcription factors are required for initiation of transcription: BTF1 (also referred to as TFIID (show TBP ELISA Kits)) which has recently been cloned from yeast, BTF2 (show GTF2H1 ELISA Kits), BTF3 and STF.
Six putative caspase (show CASP3 ELISA Kits) substrates, including five novel proteins (ABCF1 (show ABCF1 ELISA Kits), AKAP1 (show AKAP1 ELISA Kits), CPE (show CPE ELISA Kits), DOPEY1 and GOPC1 (show GOPC ELISA Kits)) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10 (show CASP10 ELISA Kits)]
This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.
basic transcription factor 3
, transcription factor BTF3
, RNA polymerase B transcription factor 3
, nascent-polypeptide-associated complex beta polypeptide