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HLCS encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. Additionally we are shipping Biotin-Protein Ligase Proteins (5) and Biotin-Protein Ligase Kits (2) and many more products for this protein.
Showing 10 out of 29 products:
Human Polyclonal HLCS Primary Antibody for ICC, IF - ABIN4319286
Niers, Chen, Weissleder, Tannous: Enhanced in vivo imaging of metabolically biotinylated cell surface reporters. in Analytical chemistry 2011
The function of HCS and biotin in metabolism and human disease, a putative role for the enzyme in histone biotinylation, and its participation as a nuclear factor in chromatin dynamics is discussed.
The transcriptional function of HCS was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1 (show HDAC1 Antibodies), HDAC2 (show HDAC2 Antibodies) and HDAC7 (show HDAC7 Antibodies)
Data suggest that direct interactions of HLCS (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1 (show NCOR1 Antibodies)) and HDAC1 (histone deacetylase 1 (show HDAC1 Antibodies)) contribute toward transcriptional repression of repeats, presumably increasing genome stability.
study characterizes three functional promoters in the human HLCS gene
HLCS interacts physically with the DNA methyltransferase (show DNMT1 Antibodies) DNMT1 (show DNMT1 Antibodies) and the methyl CpG binding protein MeCP2 to facilitate the binding of HLCS to chromatin.
This study showed that modification of HSP72 (show HSPA1A Antibodies) and demonstrated that binding of biotin to extracellular HSP72 (show HSPA1A Antibodies) prepares cells for a strong immune response.
individuals with HLCS SNPs may benefit from supplemental biotin, yet to different extents depending on the genotype
HLCS methionine-58 is a functional translation start site in human cells.
Holocarboxylase synthetase interacts directly with histone H3 (show HIST3H3 Antibodies), causing biotinylation of lysine K9 and K18 (show KRT18 Antibodies).
Mutation analysis by polymerase chain reaction-sequencing of the entire coding region of the HLCS gene revealed the c.1522C>T (p.R508W) mutation in six of the eight mutant alleles. suggests it as the most common mutation in the Thai population
This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.
biotin apo-protein ligase
, biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase
, biotin--protein ligase
, biotin--[acetyl-CoA-carboxylase] ligase
, biotin--[methylcrotonoyl-CoA-carboxylase] ligase
, biotin--[methylmalonyl-CoA-carboxytransferase] ligase
, holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
, holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)