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may be involved in apoptosis of neuronal cells. Additionally we are shipping Brain Protein 44-Like Antibodies (33) and Brain Protein 44-Like Proteins (4) and many more products for this protein.
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GTPBP3 (show GTPBP3 ELISA Kits) plays a role in the regulation of MCP1 (show CCL2 ELISA Kits) protein through AMPK (show PRKAA1 ELISA Kits) signaling.
Tumor cells expressing MPC1 and MPC2 (show BRP44 ELISA Kits) display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture.
genetic studies of 3 families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1 (BRP44L) changing single amino acids that are conserved throughout eukaryotes; data demonstrate that Mpc1 and Mpc2 (show BRP44 ELISA Kits) form an essential part of the mitochondrial pyruvate carrier
This resulted in embryonic lethality at around E13.5. Mouse embryonic fibroblasts (MEFs) derived from mutant mice displayed defective pyruvate-driven respiration as well as perturbed metabolic profiles, and both defects could be restored by reexpression of MPC1.
Oxidative glutaminolysis supports the TCA cycle in mouse cells lacking MPC1/2.
The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene.
brain protein 44-like
, brain protein 44-like protein a
, brain protein 44-like protein b
, brain protein 44-like protein
, putative brain protein 44-like variant 2
, mitochondrial pyruvate carrier 1
, HSPC040 protein
, apoptosis-regulating basic protein