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Involved in mRNA splicing (By similarity).. Additionally we are shipping BCAS2 Antibodies (79) and many more products for this protein.
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Chromosomal breakpoints involved the BCAS2 gene in 1q31 is associated with Diffuse Large B-Cell Lymphomas.
BCAS2 interacts with HSF4 (show HSF4 Proteins) and negatively regulates its protein stability via ubiquitination.
These results demonstrate that Aurora B (show AURKB Proteins) inhibits both direct interaction with the microtubule and oligomerization of the Dam1 complex to drive error correction during mitosis.
BCAS2 is a novel androgen receptor (show AR Proteins)-interacting protein (show RIPK1 Proteins).
ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST (show FST Proteins)-mediated regulation of E-cadherin (show CDH1 Proteins)
The BCAS2 gene was amplified in two of 60 primary breast cancer tissues, but not in other cancer cells, providing the first evidence of amplification within this region and indicating that BCAS2 gene codes for a nuclear protein.
This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function.
BCAS2 directly interacts with p53 (show TP53 Proteins) to reduce p53 (show TP53 Proteins) transcriptional activity by mildly but consistently decreasing p53 (show TP53 Proteins) protein in the absence of DNA damage. In the presence of DNA damage, BCAS2 prominently reduces p53 (show TP53 Proteins) protein.
Maternal BCAS2 protects genomic integrity in mouse early embryonic development.
Involved in mRNA splicing (By similarity).
breast carcinoma amplified sequence 2
, breast carcinoma-amplified sequence 2 homolog
, pre-mRNA-splicing factor SPF27
, DNA amplified in mammary carcinoma 1 protein
, breast carcinoma-amplified sequence 2
, spliceosome associated protein, amplified in breast cancer
, spliceosome-associated protein SPF 27
, protein BCAS2 homolog