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BRD1 encodes a protein of unknown function. Additionally we are shipping Bromodomain Containing 1 Antibodies (49) and Bromodomain Containing 1 Kits (3) and many more products for this protein.
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Structural and mechanistic insights into regulation of HBO1 (show MYST2 Proteins) histone acetyltransferase activity by BRPF2 have been presented.
Reduced BRD1 expression is associated with Schizophrenia.
Findings show that BRD1 primarily binds in close proximity to transcription start sites and regulates expression of numerous genes, many of which are involved with brain development and susceptibility to mental disorders.
The PHD (show PDC Proteins) finger of BRPF2 can potentially bind DNA non-specifically with an evolutionarily conserved and positively charged surface.
Recognition of unmodified histone H3 (show HIST3H3 Proteins) by the first PHD (show PDC Proteins) finger of bromodomain-PHD finger protein 2 (show PHF2 Proteins) provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF (show KAT6B Proteins)).
BRD1 may have a role in schizophrenia and bipolar affective disorder
The association of BRD1 with schizophrenia in a Japanese population, was analysed.
These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease.
BRPF2-MOZ complexes play an important role in the differentiation of embryonic stem cells via H3K14 acetylation.
Brd1-mediated Hbo1 (show MYST2 Proteins) activity is crucial for efficient activation of CD8 (show CD8A Proteins) expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 (show CD8A Proteins) enhancers.
The Hbo1 (show MYST2 Proteins)-Brd1 complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator (show GIPC1 Proteins) genes.
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
bromodomain-containing protein 1
, bromodomain containing 1
, bromodomain containing protein 1
, bromodomain-containing protein 1-like
, BR140-like protein
, bromodomain and PHD finger-containing protein 2