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BUB1B encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1B Proteins (8) and BUB1B Kits (1) and many more products for this protein.
Showing 10 out of 180 products:
Human Monoclonal BUB1B Primary Antibody for CyTOF, FACS - ABIN151818
Chan, Jablonski, Sudakin, Hittle, Yen: Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. in The Journal of cell biology 1999
Show all 7 Pubmed References
Human Polyclonal BUB1B Primary Antibody for WB - ABIN2801914
Donadelli, Benatti, Remuzzi, Morigi, Gullans, Benigni, Remuzzi, Noris: Identification of a novel gene--SSK1--in human endothelial cells exposed to shear stress. in Biochemical and biophysical research communications 1998
Show all 5 Pubmed References
Human Monoclonal BUB1B Primary Antibody for IHC (p), PLA - ABIN560109
Chambers: The molecular basis of pluripotency in mouse embryonic stem cells. in Cloning and stem cells 2005
Show all 5 Pubmed References
Human Polyclonal BUB1B Primary Antibody for IP, WB - ABIN152011
Tang, Erikson, Liu: Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 5 Pubmed References
Human Monoclonal BUB1B Primary Antibody for IF, WB - ABIN968854
Mizunuma, Hirata, Miyahara, Tsuchiya, Miyakawa: Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. in Nature 1998
Show all 3 Pubmed References
Human Monoclonal BUB1B Primary Antibody for IF, WB - ABIN968853
Wu, Lan, Li, Wu, Weinstein, Sakamoto, Dai: p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase. in Oncogene 2000
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Human Polyclonal BUB1B Primary Antibody for ICC, IF - ABIN251710
On, Chen, Ma, Chow, Poon: Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01. in Molecular cancer therapeutics 2011
Human Monoclonal BUB1B Primary Antibody for ICC, IF - ABIN2668286
Liu, Rattner, Jablonski, Yen: Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. in The Journal of cell biology 2006
Human Polyclonal BUB1B Primary Antibody for IF (p), IHC (p) - ABIN713831
Qu, Zou, Zhang, Sheng, Wang, Wang, Wang, Ji: Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. in Molecular medicine reports 2016
Together, our findings demonstrate that Bub1 (show BUB1 Antibodies) acts at multiple points to assure the correct kinetochore formation.
The Bub3 (show BUB3 Antibodies)-BubR1 complex on broken DNA inhibits the APC (show APC Antibodies)/C locally via the sequestration of Cdc20 (show CDC20 Antibodies).
a model in which Polo (show PLK1 Antibodies) controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 (show CDC20 Antibodies) kinetochore recruitment and sustained SAC (show ADCY10 Antibodies) function.
Data show that the Mad2 (show MAD2L1 Antibodies) kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 (show CDC20 Antibodies) to kinetochores in Drosophila requires BubR1 but not Mad2 (show MAD2L1 Antibodies).
Reduced BubR1 or Polo (show PLK1 Antibodies) function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in adult survival.
BubR1's role in mitosis is discussed.
BubR1 is required for normal synchrony and progression of syncytial nuclei through mitosis and to maintain the mitotic arrest of the polar body chromosomes after completion of meiosis
BubR1 is required to promote stable microtubule kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E (show CENPE Antibodies).
Recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20 (show CDC20 Antibodies)-APC (show APC Antibodies) function, preventing the metaphase-to-anaphase transition.
Results from phylogenomic study identified of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint
BubR1 N-terminal domain was necessary, but not sufficient to protect against aneuploidy and cancer. In contrast, BubR1 lacking the internal Cdc20 (show CDC20 Antibodies)-binding domain provided protection against both, which coincided with improved microtubule-kinetochore attachment error correction and spindle assembly checkpoint activity.
Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.
Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (show MYO5A Antibodies) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors
structure of the PP2A (show PPP2R4 Antibodies) B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A (show PPP2R4 Antibodies) to specific targets.
Overexpression of BUB1B is associated with Invasive Breast Cancer.
we showed that BubR1 and Mad2 (show MAD2L1 Antibodies) are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.
The integrity of the mitotic checkpoint (show BUB3 Antibodies) complex depends on the specific recognition between BubR1 and Bub3 (show BUB3 Antibodies), for which the BubR1 Gle2 (show RAE1 Antibodies) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 and BUB3 (show BUB3 Antibodies) by BUB1 (show BUB1 Antibodies) is dispensable for SAC (show ADCY10 Antibodies) activation
Data suggest that both BubR1 and SNCG may be promising predictive marker rather than prognostic marker in patients with breast cancer.
Consistent with defective myelination, BubR1(H/H) mice exhibited various motor deficits, including impaired motor strength, coordination, and balance, irregular gait patterns and reduced locomotor activity.
EZH2 (show EZH2 Antibodies) directly interacted with and stabilized BubR1, an effect driving EZH2 (show EZH2 Antibodies) into the concert of meiosis regulation.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 Antibodies), and Ercc1 (show ERCC1 Antibodies)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (show ERCC1 Antibodies)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (show SGOL1 Antibodies) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.
BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.
Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.
the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 (show SIRT2 Antibodies) to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP (show CREBBP Antibodies).
BubR1 insufficiency elicits an aging response that is counteracted by p53 (show TP53 Antibodies) and involves single or multiple p53 (show TP53 Antibodies) targets, depending on the tissue type.
BubR1 acetylation is essential for embryonic development.
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog beta
, budding uninhibited by benzimidazoles 1 beta
, budding uninhibited by benzimidazoles 1 homolog beta
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta
, budding uninhibited by benzimidazoles 1 homolog beta (yeast)
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like
, bub related one
, MAD3/BUB1-related protein kinase
, mitotic checkpoint kinase MAD3L
, budding uninhibited by benzimidazoles 1 homolog, beta