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BUB1B encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1B Proteins (6) and BUB1B Kits (1) and many more products for this protein.
Showing 10 out of 173 products:
Human Monoclonal BUB1B Primary Antibody for CyTOF, FACS - ABIN151818
Chan, Jablonski, Sudakin, Hittle, Yen: Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. in The Journal of cell biology 1999
Show all 7 references for ABIN151818
Human Polyclonal BUB1B Primary Antibody for EIA, IHC (p) - ABIN4620393
Chan, Schaar, Yen: Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. in The Journal of cell biology 1998
Show all 5 references for ABIN4620393
Human Polyclonal BUB1B Primary Antibody for IP, WB - ABIN152011
Tang, Erikson, Liu: Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 5 references for ABIN152011
Human Monoclonal BUB1B Primary Antibody for IF - ABIN393631
Suijkerbuijk, van Osch, Bos, Hanks, Rahman, Kops: Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy. in Cancer research 2010
Show all 5 references for ABIN393631
Human Polyclonal BUB1B Primary Antibody for IHC (p), WB - ABIN392627
Cahill, da Costa, Carson-Walter, Kinzler, Vogelstein, Lengauer: Characterization of MAD2B and other mitotic spindle checkpoint genes. in Genomics 1999
Show all 4 references for ABIN392627
Human Monoclonal BUB1B Primary Antibody for IF, WB - ABIN968853
Mizunuma, Hirata, Miyahara, Tsuchiya, Miyakawa: Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. in Nature 1998
Show all 3 references for ABIN968853
Mouse (Murine) Polyclonal BUB1B Primary Antibody for IHC (fro), WB - ABIN265006
Davenport, Fernandes, Harris, Neale, Goorha: The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner. in Genomics 1999
Human Polyclonal BUB1B Primary Antibody for ICC, IF - ABIN251710
On, Chen, Ma, Chow, Poon: Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01. in Molecular cancer therapeutics 2011
Human Polyclonal BUB1B Primary Antibody for ELISA, WB - ABIN1533524
Cahill, Lengauer, Yu, Riggins, Willson, Markowitz, Kinzler, Vogelstein: Mutations of mitotic checkpoint genes in human cancers. in Nature 1998
Together, our findings demonstrate that Bub1 (show BUB1 Antibodies) acts at multiple points to assure the correct kinetochore formation.
The Bub3 (show BUB3 Antibodies)-BubR1 complex on broken DNA inhibits the APC (show APC Antibodies)/C locally via the sequestration of Cdc20 (show CDC20 Antibodies).
a model in which Polo (show PLK1 Antibodies) controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 (show CDC20 Antibodies) kinetochore recruitment and sustained SAC (show ADCY10 Antibodies) function.
Data show that the Mad2 (show MAD2L1 Antibodies) kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 (show CDC20 Antibodies) to kinetochores in Drosophila requires BubR1 but not Mad2 (show MAD2L1 Antibodies).
Reduced BubR1 or Polo (show PLK1 Antibodies) function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in adult survival.
BubR1's role in mitosis is discussed.
BubR1 is required for normal synchrony and progression of syncytial nuclei through mitosis and to maintain the mitotic arrest of the polar body chromosomes after completion of meiosis
BubR1 is required to promote stable microtubule kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E (show CENPE Antibodies).
Recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20 (show CDC20 Antibodies)-APC (show APC Antibodies) function, preventing the metaphase-to-anaphase transition.
Overexpression of BUB1B is associated with Invasive Breast Cancer.
we showed that BubR1 and Mad2 (show MAD2L1 Antibodies) are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.
The integrity of the mitotic checkpoint (show BUB3 Antibodies) complex depends on the specific recognition between BubR1 and Bub3 (show BUB3 Antibodies), for which the BubR1 Gle2 (show RAE1 Antibodies) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 and BUB3 (show BUB3 Antibodies) by BUB1 (show BUB1 Antibodies) is dispensable for SAC (show ADCY10 Antibodies) activation
Data suggest that both BubR1 and SNCG (show SNCG Antibodies) may be promising predictive marker rather than prognostic marker in patients with breast cancer.
BubR1 knockdown significantly decreased cellular invasion but slightly affect cellular proliferation on both Ca9 (show CA9 Antibodies)-22 and Cal (show FBLIM1 Antibodies)-27 cells.
BubR1 contributes to preventing premature aging. [review]
Suggest human papillomavirus E2 protein (show UBE2B Antibodies) provokes BUBR1-dependent aneuploidy in HPV-induced cervical cancer.
In conclusion, the results presented here suggest that Mad2 (show MAD2L1 Antibodies) and BubR1 could be used as prognostic markers of tumor progression and new pharmacological targets in the treatment for gastric cancer .
Co-depletion of MAD2 (show MAD2L1 Antibodies) and BUBR1 causes cell cycle arrest and cell death in addition to aneuploidy.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 Antibodies), and Ercc1 (show ERCC1 Antibodies)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (show ERCC1 Antibodies)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (show SGOL1 Antibodies) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.
BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.
Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.
the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 (show SIRT2 Antibodies) to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP (show CREBBP Antibodies).
BubR1 insufficiency elicits an aging response that is counteracted by p53 (show TP53 Antibodies) and involves single or multiple p53 (show TP53 Antibodies) targets, depending on the tissue type.
BubR1 acetylation is essential for embryonic development.
these data demonstrate that the BUBR1 GTTA mutation compromises longevity and healthspan, raising the interesting possibility that mono-allelic changes in BUBR1 might contribute to differences in aging rates in the general population.
Hhigh-level expression of BubR1 extends lifespan and delays age-related deterioration and aneuploidy in several tissues.
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog beta
, budding uninhibited by benzimidazoles 1 beta
, budding uninhibited by benzimidazoles 1 homolog beta
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta
, budding uninhibited by benzimidazoles 1 homolog beta (yeast)
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like
, bub related one
, MAD3/BUB1-related protein kinase
, mitotic checkpoint kinase MAD3L
, budding uninhibited by benzimidazoles 1 homolog, beta