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C-Type Lectin Domain Family 2, Member D Proteins (CLEC2D)

CLEC2D encodes a member of the natural killer cell receptor C-type lectin family. Additionally we are shipping CLEC2D Antibodies (39) and CLEC2D Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLEC2D 93694 Q91V08
CLEC2D 29121 Q9UHP7
CLEC2D 113937 Q925N7
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Top CLEC2D Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,286.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CLEC2D Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
, ,
Rat (Rattus) ,
,

Top referenced CLEC2D Proteins

  1. Human CLEC2D Protein expressed in Escherichia coli (E. coli) - ABIN1098758 : Hu, Zhou, Myers, Quinn, Atkins, Ly, Gange, Kartsogiannis, Elliott, Kostakis, Zannettino, Cromer, McKinstry, Findlay, Gillespie, Ng: Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 (PubMed)
    Show all 2 references for ABIN1098758

More Proteins for C-Type Lectin Domain Family 2, Member D (CLEC2D) Interaction Partners

Mouse (Murine) C-Type Lectin Domain Family 2, Member D (CLEC2D) interaction partners

  1. Data suggest that killer cell lectin-like receptors NKR (show TACR3 Proteins)-P1B:Clr-b (Klrb1 (show KLRB1 Proteins):Clec2d) interactions may provide a model for human hematopoietic cell transplants.

  2. Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.

  3. LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Proteins) contributes to modulate immune responses

  4. cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules.

  5. Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells.

  6. Limited divergence of the BALB/c Nkrp1-Ocil/Clr region helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.

  7. OCIL is a physiological negative regulator of bone.

  8. PTHrp(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2 (show CA2 Proteins)+)/CaMK II (show CAMK2B Proteins), and MAPK (show MAPK1 Proteins) signaling pathways.

  9. Identification of a novel family of genes, named Clr (show CALCR Proteins), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.

  10. Mouse Nkrp1d and Nkrp1f (show KLRB1F Proteins) bind specific C-type lectin-related (Clr (show CALCR Proteins)) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr (show CALCR Proteins) are intertwined in a genetically conserved NKC region.

Human C-Type Lectin Domain Family 2, Member D (CLEC2D) interaction partners

  1. these data suggest that LLT1-CD161 (show KLRB1 Proteins) interactions play a novel and important role in B cell maturation (show TNFRSF17 Proteins) within the Germinal center in humans.

  2. In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage.

  3. The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin (show MBL2 Proteins)-like proteins in the glycosylated form.

  4. One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33)

  5. LLT1 and CD161 (show KLRB1 Proteins) have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Proteins) contributes to modulate immune responses

  6. Molecular basis for LLT1 protein recognition by human CD161 (show KLRB1 Proteins) protein (NKRP1A/KLRB1 (show KLRB1 Proteins)).

  7. Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.

  8. LLT1 used Src (show SRC Proteins)-PTK, p38 (show CRK Proteins) and ERK (show EPHB2 Proteins) signalling pathways, but not PKC (show PRRT2 Proteins), PI3K (show PIK3CA Proteins) or calcineurin (show PPP3CA Proteins) pathways, to increase production of IFN-gamma (show IFNG Proteins) by human natural killer cells.

  9. LLT1 induces Interferon (show IFNA Proteins) Type II production by natural killer cells.

  10. Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells [OCIL].

CLEC2D Protein Profile

Protein Summary

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.

Gene names and symbols associated with CLEC2D

  • C-type lectin domain family 2, member D (CLEC2D)
  • C-type lectin domain family 2, member d (Clec2d)
  • C-type lectin domain family 2, member D (Clec2d)
  • B-LEC protein
  • Blec protein
  • Blec1 protein
  • CLAX protein
  • CLEC2D protein
  • Clec2d5 protein
  • Clr-b protein
  • Clrb protein
  • LLT1 protein
  • OCIL protein

Protein level used designations for CLEC2D

osteoclast inhibitory lectin , c-type lectin-like receptor , C-type lectin domain family 2, member D , C-type lectin domain family 2 member D , C-type lectin-domain family 2 member D , C-type lectin-related protein B , lectin-like transmembrane protein , C-type lectin related f , C-type lectin superfamily 2, member D , LLT-1 , lectin-like NK cell receptor , lectin-like transcript 1 , C-type lectin domain family 2 member D5

GENE ID SPECIES
404776 Gallus gallus
617565 Bos taurus
737015 Pan troglodytes
427735 Gallus gallus
93694 Mus musculus
29121 Homo sapiens
611449 Canis lupus familiaris
113937 Rattus norvegicus
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