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NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971 [PubMed 5552408]).[supplied by OMIM, Mar 2008].. Additionally we are shipping CD177 Antibodies (136) and CD177 Kits (9) and many more products for this protein.
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Data show that CD177 protein is monoallelically expressed in neutrophils and neutrophil-differentiated hematopoietic stem cells (HSCs).
Abundance of CD177hi neutrophils correlates with homozygosity for CD177 reference allele, while heterozygosity for ectopic CD177P1 gene conversion correlates with increased CD177neg neutrophils, in which both CD177P1 partially incorporated allele and paired intact CD177 allele are transcribed
Data indicate that high percentage of CD177 antigen-positive neutrophils undergo dynamic change during sepsis.
the CD177 SNP is the primary genetic determinant for HNA-2 deficiency and expression variations. The mechanistic delineation of HNA-2 genetics will enable the development of genetic tests for diagnosis and prognosis of HNA-2-related human diseases.
This is the first report showing a prognostic correlation between CD177 expression and solid tumor behavior.
Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders.
CD177/PECAM-1 (show PECAM1 Proteins) adhesive interaction, while contributing to neutrophil-endothelial cell interaction in neutrophil transendothelial migration, does not contribute to or is redundant in platelet-neutrophil interactions
PRV1 overexpression is associated with Essential Thrombocythemia and Myelofibrosis.
NB1-proteinase 3 (show PRTN3 Proteins) interactions may play a role in aiding neutrophil transmigration.
pivotal role of the NB1-Mac-1 receptor interaction for PR3-ANCA-mediated neutrophil activation
Herein we established a novel genetic mouse model to study the role of CD177 and found that CD177 plays an important role in neutrophils.
NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971
, CD177 molecule
, CD177 antigen-like
, NB1 glycoprotein
, cell surface receptor
, human neutrophil alloantigen 2a
, polycythemia rubra vera 1
, polycythemia rubra vera protein 1