Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
May play a role in angiogenesis or vascular function.. Additionally we are shipping CD248 Proteins (7) and CD248 Kits (2) and many more products for this protein.
Showing 10 out of 80 products:
Human Polyclonal CD248 Primary Antibody for IHC, ELISA - ABIN1003255
Christian, Ahorn, Koehler, Eisenhaber, Rodi, Garin-Chesa, Park, Rettig, Lenter: Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. in The Journal of biological chemistry 2001
Show all 4 references for 1003255
Human Polyclonal CD248 Primary Antibody for IHC, ELISA - ABIN1003256
Nanda, St Croix: Tumor endothelial markers: new targets for cancer therapy. in Current opinion in oncology 2003
Show all 4 references for 1003256
Human Polyclonal CD248 Primary Antibody for FACS, IF (p) - ABIN917320
Farinon, Clarimundo, Pedrazza, Gulko, Zuanazzi, Xavier, de Oliveira: Disease modifying anti-rheumatic activity of the alkaloid montanine on experimental arthritis and fibroblast-like synoviocytes. in European journal of pharmacology 2017
the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer
Our data show that deletion of CD248 reduces susceptibility to liver fibrosis via an effect on PDGF (show PDGFA Antibodies) signaling.
Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis.
suggest that CD248 stromal cells have a pathogenic role in renal fibrosis
We conclude that CD248 is required for PDGFRbeta-dependant capillary sprouting but not splitting angiogenesis, and identify a new role for CD248 expressed on pericytes in the early stages of physiological angiogenesis during muscle remodelling.
Tem1-TT vaccination elicited CD8+ and/or CD4+ T cell responses against immunodominant TEM1 protein sequences. Prophylactic immunization of animals with Tem1-TT prevented or delayed tumor formation in several tumor models.
Expression of CD248 was seen in osteoblasts, but not osteoclasts. CD248(-/-) mouse tibiae had higher bone mass and superior mechanical properties compared to WT mice. Primary osteoblasts from CD248(-/-) mice induced increased bone mineralization
The multiple pathways regulated by the cytoplasmic domain of CD248 highlight its potential as a therapeutic target to treat cancer.
our observations suggest that Tem1 is expressed throughout embryonic and adult development in several types of mesenchymal cells closely related to blood vessels.
Tem1 have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process
Tumour cell endosialin expression was seen in 89% of undifferentiated pleomorphic sarcomas, 77% of adult fibrosarcomas/spindle cell sarcomas, 62% of synovial sarcomas, 51% of leiomyosarcomas and 31% of rhabdomyosarcomas.
CD248 overexpression is possibly involved in the pathogenesis of IPF and it has potential as a disease severity marker.
TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer
MORAb-004 reduced CD248 on pericytes, impaired tumor microvasculature maturation and ultimately suppressed tumor development.
The authors show that endosialin, a C-type lectin (show MBL2 Antibodies), expressed in the liver exclusively by HSC (show FUT1 Antibodies) and portal fibroblasts, is upregulated in liver fibrosis in mouse and man.
The genes CD248, Ephb1 (show EPHB1 Antibodies) and P2RY2 (show P2RY2 Antibodies) were detected as the top overexpressed in GC biopsies.
new monoclonal antibodies described in this paper are domain-specific and represent important reagents for the study of functional contributions of extracellular endosialin domains
[review] CD248 is a C-type lectin (show MBL2 Antibodies)-like domain-containing cell surface glycoprotein (show GJA8 Antibodies) that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions.
May play a role in angiogenesis or vascular function.
CD164 sialomucin-like 1
, CD248 antigen, endosialin
, tumor endothelial marker 1