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The protein encoded by CDC42BPA is a member of the Serine/Threonine protein kinase family. Additionally we are shipping CDC42BPA Antibodies (61) and many more products for this protein.
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ICAP-1 (show ITGB1BP1 Proteins) monoubiquitylation helps in switching from ROCK2 (show ROCK2 Proteins)-mediated to MRCKalpha-mediated cell contractility.
Data show that the fusion gene cyclin D1 (show CCND1 Proteins)/myotonic dystrophy kinase-related CDC42-binding protein kinase alpha (CCND1 (show CCND1 Proteins)/MRCK) mRNA is resistant to CCND1 (show CCND1 Proteins)-targeted miRNA regulation.
the functional relevance of the LRAP25-MRCK complex in LIMK1 (show LIMK1 Proteins)-cofilin (show CFL1 Proteins) signaling and the importance of LRAP (show ERAP2 Proteins) adaptors as key determinants of MRCK cellular localization and downstream specificities.
MRCK participates in mediating the effects of HMI-1a3 on HeLa cell morphology.
A functional pathway involving PDK1-mediated activation of MRCKA, links EGF signaling to myosin contraction and directional migration.
Data show that chelerythrine blocks cellular activity of MRCK resulted in the specific loss of NM II-associated MLC phosphorylation in the lamella, and the consequential suppression of cell migration.
MRCKalpha takes part in transferrin (show Tf Proteins) (Tf)-iron uptake, probably via regulation of Tf- TfR (show TFRC Proteins) endocytosis/endosome trafficking that is dependent on the cellular cytoskeleton.
Class II histone deacetylases are directly recruited by BCL6 (show BCL6 Proteins) transcriptional repressor
a Cdc42 (show CDC42 Proteins)-MRCK signal mediates myosin-dependent cell motility and there is convergence between Rho and Cdc42 (show CDC42 Proteins) signalling
The level of MRCKalpha mRNA in various tissues strongly positively correlates with the level of TfR (show TFRC Proteins) mRNA, indicating its possible role in the transferrin (show Tf Proteins) iron uptake pathway.
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.
serine/threonine-protein kinase MRCK alpha
, CDC42 binding protein kinase alpha (DMPK-like)
, CDC42 binding protein kinase alpha-like
, serine/threonine-protein kinase MRCK alpha-like
, CDC42-binding protein kinase alpha
, myotonic dystrophy kinase-related CDC-42-binding kinase-alpha
, MRCK alpha
, Ser-Thr protein kinase related to the myotonic dystrophy protein kinase
, myotonic dystrophy kinase-related CDC42-binding kinase alpha
, myotonic dystrophy protein kinase-like alpha
, mytonic dystrophy kinase-related Cdc42-binding kinase
, CDC42 binidng protein kinase beta
, CDC42-binding protein kinase alpha (DMPK-like)
, DMPK-like alpha
, myotonic dystrophy kinase-related CDC42-binding protein kinase alpha
, ser-thr protein kinase PK428
, ser-thr protein kinase related to the myotonic dystrophy protein kinase