CREB Regulated Transcription Coactivator 1 Proteins (CRTC1)

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Antibodies (77) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CRTC1 23373 Q6UUV9
CRTC1 382056 Q68ED7
CRTC1 684527 Q157S1
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Top CRTC1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,822.50
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HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$560.00
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CRTC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for CREB Regulated Transcription Coactivator 1 (CRTC1) Interaction Partners

Human CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. MECT1-MAML2 fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma

  2. CRTC1 as new mediator of PGE2 signaling

  3. Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells

  4. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma

  5. CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals.

  6. DNA methylation (show HELLS Proteins) levels within two distinct promoter regions of the CREB regulated transcription coactivator 1 gene were decreased in human hippocampus affected by Alzheimer disease.

  7. Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC (show CCL28 Proteins) diagnosis but is not associated with differences in survival outcomes.

  8. A specific CRTC1-MAMl2-induced transcriptional program was identified in mucoepidermoid carcinoma cells.

  9. Translocation t(11;19)(q14-21;p12 (show POLE4 Proteins)-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13.

  10. This study showed that CREB (show CREB1 Proteins)-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication.

Mouse (Murine) CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. Three mouse CRTCs (Crtc1, Crtc2 (show CRTC2 Proteins) and Crtc3 (show CRTC3 Proteins)) exhibit distinct patterns of 14-3-3 (show YWHAQ Proteins) binding at three conserved sites corresponding to S70, S171 (show NUMB Proteins), and S275 (in CRTC2 (show CRTC2 Proteins)).

  2. The NR2B (show GRIN2B Proteins)-CREB (show CREB1 Proteins)-miR212/132-CRTC1-CREB (show CREB1 Proteins) signal network plays an important role in the regulation of pain.

  3. Findings reveal a critical role of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus during associative memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegeneration.

  4. Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt (show AKT1 Proteins) indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response

  5. Study suggests that CRTC1 is a key regulator of behavioral and molecular response to antidepressant: CRTC1 is required for complete behavioral antidepressant response and for desipramine-induced expression of Bdnf (show BDNF Proteins) and Nr4a1 (show NR4A1 Proteins)-2. By acting downstream of CRTC1, the HDAC (show HDAC3 Proteins) inhibitor SAHA improves the depressive-like behavior of Crtc1-/- mice.

  6. IL-4 (show IL4 Proteins) signaling co-opts the Akt (show AKT1 Proteins)-mTORC1 pathway to regulate Acly (show ACLY Proteins), a key enzyme in acetyl-CoA (show LPCAT1 Proteins) synthesis, leading to increased histone acetylation and macrophage gene induction.

  7. Upregulation of CRTC1 enhancing CREB (show CREB1 Proteins)-dependent gene transcription in spinal cord may play an important role in bone cancer pain.

  8. This study demonstrates that TSC1 (show TSC1 Proteins)- mechanistic target of rapamycin (show FRAP1 Proteins) complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]

  9. These data identify Notch (show NOTCH1 Proteins) as a therapeutically actionable branch point of metabolic signaling at which Akt (show AKT1 Proteins) activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]

  10. aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 (show MTM1 Proteins) [mTORC1]

CRTC1 Protein Profile

Protein Summary

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.

Gene names and symbols associated with CRTC1

  • CREB regulated transcription coactivator 1 (CRTC1)
  • CREB regulated transcription coactivator 1 (crtc1)
  • CREB regulated transcription coactivator 1 (Crtc1)
  • AI413414 protein
  • CRTC1 protein
  • Mect1 protein
  • mKIAA0616 protein
  • R74955 protein
  • TORC-1 protein
  • TORC1 protein
  • WAMTP1 protein

Protein level used designations for CRTC1

CREB-regulated transcription coactivator 1 , mucoepidermoid carcinoma translocated 1 , CREB regulated transcription coactivator 1 , CREB-regulated transcription coactivator 1-like , mucoepidermoid carcinoma translocated protein 1 , transducer of regulated cAMP response element-binding protein (CREB) 1 , TORC-1 , mucoepidermoid carcinoma translocated protein 1 homolog , transducer of CREB protein 1 , transducer of regulated cAMP response element-binding protein 1

GENE ID SPECIES
100523662 Sus scrofa
510465 Bos taurus
720274 Macaca mulatta
735806 Pan troglodytes
771015 Gallus gallus
100036611 Xenopus (Silurana) tropicalis
100385682 Callithrix jacchus
100479645 Ailuropoda melanoleuca
100548464 Meleagris gallopavo
23373 Homo sapiens
382056 Mus musculus
684527 Rattus norvegicus
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