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May be involved in pre-mRNA splicing. Additionally we are shipping CWC22 Spliceosome-Associated Protein Homolog (S. Cerevisiae) Proteins (3) and many more products for this protein.
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Human Polyclonal CWC22 Primary Antibody for EIA, IHC (p) - ABIN951735
Jurica, Licklider, Gygi, Grigorieff, Moore: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. in RNA (New York, N.Y.) 2002
Show all 4 references for 951735
Human Polyclonal CWC22 Primary Antibody for IF, WB - ABIN528288
Alexandrov, Colognori, Shu, Steitz: Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay. in Proceedings of the National Academy of Sciences of the United States of America 2012
The binding mode of CWC22 to eIF4AIII (show EIF4A3 Antibodies) reveals a facet of how MIF4G domains use their versatile structural frameworks to activate or inhibit DEAD-box proteins.
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
The essential splicing factor (show SLU7 Antibodies) CWC22 has acquired functions in exon junction complex assembly and nonsense-mediated decay during evolution from single-celled to complex eukaryotes.
CWC22 escorts the helicase eIF4AIII (show EIF4A3 Antibodies) to spliceosomes and promotes exon junction complex assembly
Authors have reconstructed the origin and history of a 127-kbp segmental duplication, R2d, in the house mouse (Mus (show TRPV6 Antibodies) musculus). R2d contains a single protein-coding gene, Cwc22 De novo assembly of both the ancestral (R2d1) and the derived (R2d2) copies reveals that they have been subject to nonallelic gene conversion events spanning tens of kilobases.
Study showed major differences in gene copy number in natural populations. CWC22, SFI1 (show SFI1 Antibodies), and HJURP (show HJURP Antibodies) are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations.
May be involved in pre-mRNA splicing.
, lethal (2) SH0931
, nucampholin homolog
, pre-mRNA-splicing factor CWC22 homolog
, functional spliceosome-associated protein b
, Nucampholin homolog