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Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.. Additionally we are shipping CAPN1 Antibodies (132) and CAPN1 Proteins (8) and many more products for this protein.
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Results indicate that calpain-1 and calpain-2 (show CAPN2 ELISA Kits) are differentially activated in hippocampus following seizure activity, with calpain-1 activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 (show CAPN2 ELISA Kits) is widely activated in pyramidal neurons of CA1 (show CA1 ELISA Kits) and CA3 (show CA3 ELISA Kits), and triggers neurodegenerative cascades.
Here we show the combined loss of glial glutamate (show GRIN1 ELISA Kits) transporters GLT1 (show SLC1A2 ELISA Kits) and GLAST (show SLC1A3 ELISA Kits) in spinal cord caused motor neuronal death and hindlimb paralysis.
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
High calpain expression is associated with brain injury.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
calpains and calpastatin (show CAST ELISA Kits) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN ELISA Kits)-5HTT (show SLC6A4 ELISA Kits)(+) strain) PH, were investigated.
Attenuation of atherosclerotic lesions/inflammation in ApoE (show APOE ELISA Kits) KO mice by simvastatin might be associated with the downregulation of CD36 (show CD36 ELISA Kits) and calpain-1.
Leukocyte calpain-1/calpain-2 (show CAPN2 ELISA Kits) deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.
TnT3 regulates transcription of Cacna1s (show CACNA1S ELISA Kits), the gene encoding Cav1.1 (show CACNA1S ELISA Kits). Knocking down TnT3 in vivo downregulated Cav1.1 (show CACNA1S ELISA Kits).
Taken together, our findings suggested that DHRS7C maintains intracellular Ca(2+) homeostasis involving the ER/SR and that functional loss of DHRS7C leads to Ca(2+) overload in the cytosol and ER/SR, resulting in enlarged cellular morphology via calpain activation
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
calpain 1, large subunit
, CANP 1
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain-1 catalytic subunit
, calpain-1 large subunit
, calpain 1