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Calsequestrin 1 Proteins (CASQ1)

The protein encoded by CASQ1 is a mitochondrial calcium-binding protein located in the luminal space of the terminal cisternae of the sarcoplasmic reticulum. Additionally we are shipping Calsequestrin Antibodies (21) and Calsequestrin Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CASQ1 12372 O09165
CASQ1 844 P31415
CASQ1 686019 P19633
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Top Calsequestrin Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,038.67
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,004.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,019.50
Details
Yeast Rana esculenta His tag   1 mg Log in to see 56 to 66 Days
$3,102.00
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CASQ1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

Top referenced Calsequestrin Proteins

  1. Human Calsequestrin Protein expressed in Escherichia coli (E. coli) - ABIN2005916 : Slupsky, Ohnishi, Carpenter, Reithmeier: Characterization of cardiac calsequestrin. in Biochemistry 1988 (PubMed)

More Proteins for Calsequestrin 1 (CASQ1) Interaction Partners

Mouse (Murine) Calsequestrin 1 (CASQ1) interaction partners

  1. Transient knockdown of annexin A6 (show ANXA6 Proteins) and calsequestrin 1 protein of high-active mice with vivo-morpholinos resulted in decreased physical activity levels (P = 0.001).

  2. Ca(2 (show CA2 Proteins)+) transients evoked by tetanic stimulation are the result of massive Ca(2 (show CA2 Proteins)+) influx due to enhanced Ca(v)1.1 (show CACNA1S Proteins) channel activity, which restores muscle strength in JP45 (show JSRP1 Proteins)/CASQ1 double knockout mice.

  3. Protein levels of CSQ1, SERCA1 (show ATP2A1 Proteins), and SERCA2 (show ATP2A2 Proteins) are re-adjusted in skeletal muscles depending on the demands of diverse exercise training programs.

  4. results support the view that in skeletal muscles, CASQ1 plays a key role in both Ca(2 (show CA2 Proteins)+) homeostasis and terminal cisternae structure

  5. The results presented in this paper unmask a differential effect of CASQ1&2 ablation in fast versus slow fibers

  6. Calsequestrin not only stores Ca(2 (show CA2 Proteins)+), but also varies its affinity in ways that progressively increase the ability of the store to deliver Ca(2 (show CA2 Proteins)+) as it becomes depleted, a novel feedback mechanism of potentially valuable functional implications.

  7. effect of nockdown of CSQ1 in adult mouse skeletal muscle on Store-operated Ca(2 (show CA2 Proteins)+) entry

  8. knocking down CSQ2, but not CSQ1, leads to reduced Ca2 (show CA2 Proteins)+ storage and release in C2C12 myotubes

  9. CSQ1 is essential for the normal development of the sarcoplasmic reticulum (SR) and its calcium release units and for the storage and release of appropriate amounts of SR Ca(2 (show CA2 Proteins)+).

  10. Data report that calsequestrin-1-null mice exhibit increased spontaneous mortality and susceptibility to heat- and anesthetic-induced sudden death, and show that CASQ1 deficiency alters proper control of ryanodine receptor function.

Rabbit Calsequestrin 1 (CASQ1) interaction partners

  1. a mechanism for the observed in vitro and in vivo dynamic high-capacity and low-affinity Ca(2 (show CA2 Proteins)+)-binding activity of calsequestrin

  2. Purified skeletal ryanodine receptors are similarly activated by purified triadin (show TRDN Proteins) or purified junctin (show ASPH Proteins) added to their luminal side, although a lack of competition indicated that the proteins act at independent sites.

Human Calsequestrin 1 (CASQ1) interaction partners

  1. the protein aggregate myopathy with benign evolution and muscle inclusions composed of excess CASQ1 due to the D244G heterozygous missense mutation in the CASQ1 gene

  2. Equilibrium dialysis and turbidity measurements showed that D244G and, to a lesser extent, M87T partially lose Ca(2 (show CA2 Proteins)+) binding exhibited by wild type calsequestrin 1 at high Ca(2 (show CA2 Proteins)+) concentrations.

  3. Missense mutation in CASQ1 gene causes the formation of abnormal sarcoplasmic reticulum (SR) vacuoles containing aggregates of CASQ1 results in altered Ca2 (show CA2 Proteins)+ release, and vacuolar myopathy patients phenotype.

  4. The sarcoplasmic reticulum calcium content in human type II fibres is primarily determined by the CSQ1 abundance, and in type I fibres, by the combined amounts of both CSQ1 and CSQ2.

  5. a direct interaction of dysferlin with Trim72/MG53 (show TRIM72 Proteins), AHNAK (show AHNAK Proteins), cytoplasmic dynein (show DYNC1H1 Proteins), myomesin-2 and calsequestrin-1, but not with caveolin-3 (show CAV3 Proteins) or dystrophin (show DMD Proteins), is reported.

  6. CASQ1 is not a major malignant hyperthermia susceptibility locus in the North American population

  7. Downregulation of CSQ-1 in diabetic platelets and impairment of CSQ-1 in normal cells leads to disturbed Ca(2 (show CA2 Proteins)+) release, demonstrating a potential role for CSQ-1 in the regulation of the platelet Ca(2 (show CA2 Proteins)+) release process

  8. a mechanism for the observed in vitro and in vivo dynamic high-capacity and low-affinity Ca(2 (show CA2 Proteins)+)-binding activity of calsequestrin

  9. Single nucleotide polymorphisms within CASQ1 were genotyped in Amish subjects with type 2 diabetes, glucose intolerance and normals.

  10. Noncoding single nucleotide polymorphisms in CASQ1 alter diabetes susceptibility, either by a direct effect on CASQ1 gene expression or perhaps by regulating a nearby gene.

Calsequestrin (CASQ1) Protein Profile

Protein Summary

The protein encoded by this gene is a mitochondrial calcium-binding protein located in the luminal space of the terminal cisternae of the sarcoplasmic reticulum. The protein binds and putatively stores calcium ions. The protein is absent in patients with Duchenne and Becker types of muscular dystrophy.

Gene names and symbols associated with Calsequestrin 1 Proteins (CASQ1)

  • calsequestrin 1 (fast-twitch, skeletal muscle) (CASQ1)
  • calsequestrin 1b (casq1b)
  • Calsequestrin-1 (casq1)
  • calsequestrin 1 (Casq1)
  • calsequestrin 1 (fast-twitch, skeletal muscle) (Casq1)
  • calsequestrin 2 (cardiac muscle) (CASQ2)
  • CASQ protein
  • CASQ1 protein
  • CSQ protein
  • CSQ-1 protein
  • CSQ1 protein
  • PDIB1 protein
  • sCSQ protein
  • zgc:154027 protein

Protein level used designations for Calsequestrin 1 Proteins (CASQ1)

calsequestrin-1 , Calsequestrin-1 , calsequestrin, skeletal muscle isoform , aspartactin , laminin-binding protein , skeletal muscle calsequestrin 1 , calmitin , calmitine , Aspartactin , Laminin-binding protein , calsquestrin 1 , calsequestrin homologue , calsequestrin-2

GENE ID SPECIES
508394 Bos taurus
767757 Danio rerio
100195131 Salmo salar
12372 Mus musculus
100009095 Oryctolagus cuniculus
844 Homo sapiens
101118652 Ovis aries
686019 Rattus norvegicus
100156448 Sus scrofa
395198 Gallus gallus
608401 Canis lupus familiaris
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